Increased mortality in survivors of Ebola virus disease

Fausther-Bovendo, Hugues; Kobinger, Gary P.

doi:10.1016/s1473-3099(19)30429-3

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…A proportion of SARS-CoV-2 infected patients have persistent symptoms referred to as post-acute COVID syndrome or “long-COVID-19” [ 1 , 2 , 3 ]. The occurrence of post-infectious syndromes has been reported for other viral infections such as Ebola and Zika viruses [ 4 , 5 ]. However, for many Canadian healthcare practitioners, this may be their first exposure to post-viral syndromes.…”

Section: Introductionmentioning

confidence: 99%

Recognition of Long-COVID-19 Patients in a Canadian Tertiary Hospital Setting: A Retrospective Analysis of Their Clinical and Laboratory Characteristics

et al. 2021

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A proportion of patients with COVID-19 have symptoms past the acute disease phase, which may affect quality of life. It is important for clinicians to be aware of this “long-COVID-19” syndrome to better diagnose, treat, and prevent it. We reviewed clinical and laboratory characteristics of a COVID-19 cohort in a Toronto, Ontario tertiary care center. Demographic, clinical, and laboratory data were collected, and patients were classified as “long-COVID-19” or “non-long-COVID-19” using consensus criteria. Of 397 patients who tested positive for COVID-19, 223 met inclusion criteria, and 62 (27%) had long-COVID-19. These patients had a similar age distribution compared to non-long-COVID-19 patients overall but were younger in the admitted long COVID-19 group. The long-COVID-19 group had more inpatients compared to the non-long-COVID-19 group (39% vs. 25%) and more frequent supplemental oxygen or mechanical ventilation use. However, long-COVID-19 patients did not differ by duration of mechanical ventilation, length of stay, comorbidities, or values of common laboratory tests ordered. The most frequent symptoms associated with long-COVID-19 were fatigue and weakness, as reported most commonly by the infectious disease, respirology and cardiology disciplines. In conclusion, by retrospective chart review, 27% of COVID-19 patients presenting to a tertiary care center in Toronto, Canada, were found to meet criteria for long-COVID-19. Past medical history and routine laboratory testing at presentation did not predict for long-COVID-19 development.

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Section: Introductionmentioning

confidence: 99%

Recognition of Long-COVID-19 Patients in a Canadian Tertiary Hospital Setting: A Retrospective Analysis of Their Clinical and Laboratory Characteristics

et al. 2021

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“…A nationwide retrospective cohort study recently completed in Guinea (West Africa) has identified an increased risk of mortality in survivors from the devastating 2013-16 Ebola virus disease outbreak [2], individuals which will require specific countermeasures to protect their compromised health. Thus, identification of potential acute and opportunistic infections in West African countries will be crucial to identify appropriate preventive health or therapeutic interventions highlighted in light of new evidence of increased mortality in Ebola survivors [3].…”

Section: Introductionmentioning

confidence: 99%

Introducing Medical Parasitology at the University of Makeni, Sierra Leone

Pena-Fernandez¹,

Anjum²,

Koroma³

et al. 2019

ICERI Proceedings

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Capacity building in Sierra Leone (West Africa) is critical to prevent potential future outbreaks similar to the 2013-16 Ebola outbreak that had devastating effects for the country and its poorly developed healthcare system. De Montfort University (DMU) in the United Kingdom (UK), in collaboration with parasitologists from the Spanish Universities of San Pablo CEU and Miguel Hernández de Elche, is leading a project to build the teaching and research capabilities of medical parasitology at the University of Makeni (UniMak, Sierra Leone). This project has two objectives: a) to introduce and enhance the teaching of medical parasitology, both theoretical and practical; and b) to implement and develop parasitology research related to important emerging human parasites such as Cryptosporidium spp. due to their public health significance. Two UniMak academics, hired to help initiate and implement the research part of the project, shared their culturally sensitive public health expertise to broker parasitology research in communities and perform a comprehensive environmental monitoring study for the detection of different emerging human parasites. The presence of targeted parasites are being studied microscopically using different staining techniques, which in turn have allowed UniMak's academics to learn these techniques to develop new practicals in parasitology. To train UniMak's academics and develop both parts of our project, a DMU researcher visited UniMak for two weeks in April 2019 and provided a voluntary short training course in basic parasitology, which is currently not taught in any of their programmes, and was attended by 31 students. These sessions covered basic introduction to medical parasitology and life-cycle, pathogenesis, detection, treatment and prevention of: a) coccidian parasites (Cryptosporidium, Cyclospora and Cystoisospora); b) Giardia intestinalis, Entamoeba and free-living amoebas; c) malaria and d) microsporidia. A theoretical session on common staining techniques was also provided. To facilitate the teaching and learning of these parasites, the novel resource DMU e-Parasitology was used, a package developed by the above participating universities and biomedical scientists from the UK National Health Service (NHS): http://parasitology.dmu.ac.uk/ index.htm. Following the two weeks of training, UniMak's academics performed different curriculum modifications to the undergraduate programme 'Public Health: Medical Laboratory Sciences', which includes the introduction of new practicals in parasitology and changes to enhance the content of medical parasitology that will be subjected to examination. Thus, a new voluntary practical on Kinyoun stain for the detection of coccidian parasites was introduced in the final year module of 'Medical Bacteriology and Parasitology'; eighteen students in pairs processed faecal samples from pigs provided by the Department of Agriculture and Food Security from a nearby farm. Academics at UniMak used the Kinyoun staining unit (available at http://parasitology.dmu.ac....

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Increased mortality in survivors of Ebola virus disease

Cited by 2 publications

References 15 publications

Recognition of Long-COVID-19 Patients in a Canadian Tertiary Hospital Setting: A Retrospective Analysis of Their Clinical and Laboratory Characteristics

Recognition of Long-COVID-19 Patients in a Canadian Tertiary Hospital Setting: A Retrospective Analysis of Their Clinical and Laboratory Characteristics

Introducing Medical Parasitology at the University of Makeni, Sierra Leone

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