Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant

Turusov, V. S.; Nikonova, Tatiana Vasil'evna; Parfenov, Yu.D.

doi:10.1016/0304-3835(90)90123-f

Cited by 35 publications

(16 citation statements)

References 8 publications

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“…The results of this study also showed that the frequency of dominant mutations resulting in both early and late mortality is equally elevated in the offspring of irradiated males. Similar data were later obtained from the analysis of the F 1 offspring of male rats treated by cyclophosphamide ( Turusov et al, 1990). (b) Promotion of skin tumours by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the offspring of male mice acutely exposed to 4.2 Gy of X-rays (data from Vorobtsova et al, 1993).…”

Section: Transgenerational Effects In the Germ Linesupporting

confidence: 66%

“…Owing to the lack of measurable increases in tumour incidence in the offspring of exposed male mice, the later studies focused on the morphology of the tumours in the offspring of exposed males. Figure 1a presents the results of one such study assessing the effects of parental exposure to benz(a)pyrene (Turusov et al, 1990). From these data, it follows that the incidence of cancer among the offspring of exposed parents does not exceed those of the control, whereas the mean number of lung adenomas per tumour in the offspring of exposed parents remains persistently elevated over several generations.…”

Section: Cancer Predispositionmentioning

confidence: 93%

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Radiation-induced transgenerational instability

Dubrova

2003

Oncogene

155

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To date, the analysis of mutation induction has provided an irrefutable evidence for an elevated germline mutation rate in the parents directly exposed to ionizing radiation and a number of chemical mutagens. However, the results of numerous publications suggest that radiation may also have an indirect effect on genome stability, which is transmitted through the germ line of irradiated parents to their offspring. This review describes the phenomenon of transgenerational instability and focuses on the data showing increased cancer incidence and elevated mutation rates in the germ line and somatic tissues of the offspring of irradiated parents. The possible mechanisms of transgenerational instability are also discussed.

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Section: Transgenerational Effects In the Germ Linesupporting

confidence: 66%

Section: Cancer Predispositionmentioning

confidence: 93%

Radiation-induced transgenerational instability

Dubrova

2003

Oncogene

155

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“…The transgenerational effect of imprinting is surprising but it is not without precedent however. It has been observed in the case of benzpyrene exposure [15][16][17] and also after maternal exposure to opiates. 18 In humans, overfeeding by grandparents influenced the manifestation of obesity, diabetes and cardovascular diseases in their grandchildren.…”

Section: Resultsmentioning

confidence: 90%

Prolonged effect of endorphin treatment during pregnancy in the rat on the histamine content of immune cells of F1 and F2 offspring generations

Pállinger

Tóthfalusi

Csaba

2006

Cell Biochem. Funct.

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Female rats were treated with beta-endorphin on the 19th day of pregnancy and the histamine content of immune cells (blood lymphocytes; peritoneal lymphocytes, monocyte-macrophage-granulocyte group, mast cells; thymic lymphocytes) of the 7-week-old progenies (F1 generation) was studied using a flow-cytometric immunocytochemical technique. In an other group, female F1 progenies of endorphin-treated mothers were mated with control males and the F2 generation was monitored for histamine content similar to the F1. In the F1 generation each cell type, except peritoneal and blood lymphocytes, contained significantly more histamine than the control cells. In the F2 generation only mast cells contained significantly more histamine relative to the appropriate control. This means that the effect of endorphin (hormonal) imprinting is transmitted transgenerationally, but with decreasing intensity however. Mast cells retained the effect of imprinting for longer than the other cells. The results are compared with the levels of serotonin in similarly treated animals, studied in earlier experiments. As the endorphin level can be elevated during pregnancy (by pain, traumatization, or other stress conditions) this can the set biogenic amine content of adult immune cells.

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“…There is some evidence that such situations do occur. For example, exposure of pregnant mice to the carcinogen benzapyrene increased the risk of lung tumours in not only the F 1 generation but also in the F 2 -F 5 generations of mice (Turusov et al 1990).…”

Section: Mommed4mentioning

confidence: 99%

Epigenetic regulation in male germ cells

Zamudio¹,

Chong²,

O'Bryan³

2008

Reproduction

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In recent years, it has become increasingly clear that epigenetic regulation of gene expression is critical during spermatogenesis. In this review, the epigenetic regulation and the consequences of its aberrant regulation during mitosis, meiosis and spermiogenesis are described. The current knowledge on epigenetic modifications that occur during male meiosis is discussed, with special attention on events that define meiotic sex chromosome inactivation. Finally, the recent studies focused on transgenerational and paternal effects in mice and humans are discussed. In many cases, these epigenetic effects resulted in impaired fertility and potentially long-ranging affects underlining the importance of research in this area.

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Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant

Cited by 35 publications

References 8 publications

Radiation-induced transgenerational instability

Radiation-induced transgenerational instability

Prolonged effect of endorphin treatment during pregnancy in the rat on the histamine content of immune cells of F1 and F2 offspring generations

Epigenetic regulation in male germ cells

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