Increased neopterin levels and its association with angiographic variables in patients with slow coronary flow: an observational study

Varol, Ercan; Gulcan, Mehmet; Aylak, Firdevs; Özaydın, Mehmet; Sütçü, Recep; Erdoğan, Doğan; Doğan, Abdullah

doi:10.5152/akd.2011.190

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…It is known that neopterin level predicts adverse prognosis in coronary artery disease (34). Elevated serum level of neopterin as a systemic marker of IFN-γ was shown in SCF patients by Varol et al (35). …”

Section: Discussionmentioning

confidence: 92%

Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow

Faramarz-Gaznagh

Rasmi

Khadem-Ansari

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundSlow coronary flow (SCF) is a coronary artery disorder characterized with delayed opacification of epicardial coronary arteries without obstructive coronary disease. The pathophysiological mechanisms of SCF remain unclear. One of the possible mechanisms that may participate in the pathology of SCF is endothelial dysfunction related to the inflammatory process. Interferon gamma (IFN-γ) is an inflammatory cytokine that acts through its specific receptor composed of two subunits, IFN-γR1 and IFN-γR2. Transcriptional activity of the gene encoding these subunits influences IFN-γ activity. This study aimed to investigate the gene expression of IFN-γ receptor subunits in peripheral blood mononuclear cells (PBMC) from patients with SCF.MethodsThe study was performed with 30 patients (22 male/8 female) aged 35–76 (52.8±11.7 years) with SCF and 15 sex- (11 male/4 female), Body Max Index (BMI)- and age-matched (54.73±9.42 years) healthy subjects. Total mRNA was extracted from PBMC and was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). The relative expression values (2-ΔΔCt) between control and case groups were determined and the Mann-Whitney U test was used for statistical analysis.ResultsThere was a significant increase in the gene expression of IFN-γR1 in PBMC from SCF patients vs. controls (P< 0.0001); but the differences in IFN-γR2 gene expression were statistically insignificant between patient and control groups (P= 0.853).ConclusionsIt can be concluded that IFN-γ gene expression may influence the function of microvasculature and thereby contribute to the pathophysiology of SCF.

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Section: Discussionmentioning

confidence: 92%

Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow

Faramarz-Gaznagh

Rasmi

Khadem-Ansari

et al. 2016

Journal of Medical Biochemistry

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“…Besides that, inflammation has been shown to be involved in the development of CSFP [11]. Thus, inflammatory biomarkers have been extensively employed to investigate CSF [12][13][14]. Moreover, Li et al discovered that plasma CRP and interleukin 6 levels were considerably elevated in individuals with CSFP in a recent study [15].…”

Section: Discussionmentioning

confidence: 99%

Association of eosinophil-to-lymphocyte ratio with coronary slow-flow phenomenon in patients undergoing coronary angiography

Tosu

Kalyoncuoğlu

Biter

et al. 2022

Arch Med Sci Atheroscler Dis

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IntroductionThe current investigation intended to evaluate the correlation between eosinophil-to-lymphocyte ratio (ELR) and the coronary slow-flow phenomenon (CSFP) in patients undergoing elective coronary angiography.Material and methodsA case-control investigation was conducted on 200 individual CSFP patients and another 200 individuals with normal coronary arteries and who were matched for age, gender, and body mass index. ELR was computed by dividing the number of eosinophils by the number of lymphocytes. Thrombolysis in myocardial infarction frame count was used to determine the CSFP.ResultsThe ELR in the CSFP group was substantially greater than in the control group [0.38 (0.28–0.50)] and [0.22 (0.17–0.35)], p < 0.001, respectively). With the help of multivariable logistic regression analysis, ELR independently predicted the CSFP presence (odds ratio = 1.040, 95% CI: 1.026–1.053), p < 0.001). The effective cutoff point of ELR in predicting CSFP presence was > 0.29 with sensitivity of 77% and specificity of 70%. ELR had better diagnostic accuracy to predict CSFP than either lymphocyte or eosinophil count alone [AUC = 0.746 vs. AUC = 0.687 vs. AUC = 0.687, respectively].ConclusionsTo our knowledge, this was the first investigation to determine the connection between ELR and CSFP. We discovered that individuals with CSFP had higher ELR than those with normal coronary arteries in the control group.

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“…Li et al found that plasma levels of inflammatory factors, hs-CRP and IL-6 in patients with SCF were significantly higher than those of control subjects [23]. Varol et al found higher levels of neopterin, which is thought to be a marker of immune activation and macrophage activity, in the CSF group than the normal coronary flow group [24]. Selçuk et al reported that serum concentrations of adiponectin, a modulator of the inflammatory response in the vascular wall, were decreased in patients with SCF and inversely correlated with mean TIMI frame count [25].…”

Section: Discussionmentioning

confidence: 99%

Increased circulating soluble urokinase-type plasminogen activator receptor (suPAR) levels in patients with slow coronary flow

Acar

Akın

İzcı

et al. 2016

Arch Med Sci Atheroscler Dis

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IntroductionSlow coronary flow (SCF) is an angiographic phenomenon characterized by delayed opacification of epicardial coronary arteries without an obstructive coronary disease. Serum soluble urokinase-type plasminogen activator receptor (suPAR) levels seem closely related to atherosclerosis due to increased inflammation and prothrombotic state. We studied whether circulating suPAR is related to SCF.Material and methodsThe present study was cross-sectional and observational. It included 75 individuals who underwent coronary angiography with suspected CAD and had angiographically normal coronary arteries of varying coronary flow rates. The relationship between suPAR, C-reactive protein (CRP) and SCF was investigated. Forty patients with isolated SCF (mean age: 46.0 ±4.14 years) and 35 age- and gender-matched control participants with normal coronary flow (NCF) and normal coronary arteries (NCA) (mean age: 46.0 ±5.7 years) were included in the study. We used logistic regression analysis to determine the predictors of SCF.ResultsThe clinical characteristics were not statistically significantly different between SCF and NCA groups. Serum suPAR level was significantly higher in the SCF group than the control group (2.5–5.4 ng/ml vs. 0.1–1.4 ng/ml; p < 0.001). Also the serum CRP level was higher in the CSF group than the control group (1.57 ±0.43 mg/l vs. 0.53 ±0.23 mg/l; p < 0.001).ConclusionsThis study revealed significantly increased serum suPAR levels in patients with SCF. Although we cannot draw conclusions on the underlying pathological process of SCF, we believe that these findings may be pioneering for further studies investigating the specific roles of circulating suPAR in the SCF phenomenon in the coronary vasculature.

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Increased neopterin levels and its association with angiographic variables in patients with slow coronary flow: an observational study

Cited by 5 publications

References 23 publications

Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow

Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow

Association of eosinophil-to-lymphocyte ratio with coronary slow-flow phenomenon in patients undergoing coronary angiography

Increased circulating soluble urokinase-type plasminogen activator receptor (suPAR) levels in patients with slow coronary flow

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