Increased neurogenesis in a model of electroconvulsive therapy

Madsén, Torsten; Treschow, Alexandra; Bengzon, Johan; Bolwig, Tom G.; Lindvall, Olle; Tingström, Anders

doi:10.1016/s0006-3223(00)00228-6

Cited by 671 publications

(452 citation statements)

References 34 publications

Supporting

Mentioning

415

Contrasting

Unclassified

Order By: Relevance

“…Based on these findings, studies were initiated to determine if antidepressants influence neuronal remodeling, particularly neurogenesis. The results of this work reveal the exciting discovery that antidepressant treatment increases adult neurogenesis in hippocampus (Figure 3) (Malberg et al 2000b;Madsen et al 2000;Manev et al 2000;see Duman et al 2000;Jacobs et al 2000). Up-regulation of neurogenesis is observed with different classes of antidepressants, including 5-HT and NE selective reuptake inhibitors, monoamine oxidase inhibitors, and electroconvulsive seizure.…”

Section: Antidepressant Treatment Increases Adult Neurogenesismentioning

confidence: 70%

Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

428

249

View full text Add to dashboard Cite

Demonstration of neurogenesis in adult brainOur understanding of how the brain functions and undergoes adaptation and plasticity has changed dramatically over the past several years. A great deal of work has demonstrated that altered levels of neurotransmitters, second messenger pathways, and gene expression profiles underlie cellular and behavioral plasticity. This includes models of learning and memory as well as models of depression, anxiety, and psychosis, and the long-term actions of psychotropic drugs. However, it is now becoming increasing evident that changes in cellular morphology and even more pronounced alterations in brain structure also contribute to neural plasticity or remodeling. At the cellular level these changes can occur in the form of up or down-regulation of synapse formation and spine density or extension and retraction of dendrites. Another very dramatic example is up or down-regulation of neurogenesis in adult brain. Studies in recent years demonstrate that new cell birth occurs in adult brain and that the rate of neurogenesis and the survival of new neurons is regulated by a number of environmental, endocrine, and pharmacological treatments.In this paper we discuss the evidence that structural remodeling may be involved in the pathophysiology and treatment of mood disorders. The potential role of neurogenesis is also discussed as well as the molecular mechanisms which underlie antidepressant regulation of new cell birth and survival. The studies to date suggest an exciting possibility for the role of neurogenesis

show abstract

Section: Antidepressant Treatment Increases Adult Neurogenesismentioning

confidence: 70%

Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

428

249

View full text Add to dashboard Cite

show abstract

“…Both NPY and PACAP stimulate division of the progenitor cells that give rise to olfactory receptor neurons (Hansel et al 2001a,b). Generation of new neurons in the hippocampus may contribute to the antidepressant effect of ECT (Madsen et al 2000;Malberg et al 2000;Scott et al 2000) and could be controlled in part by amidated peptides.…”

Section: Repeated Ecs Elicits Marked Changes In Npy Pam and Kalirin mentioning

confidence: 99%

Plasticity in Hippocampal Peptidergic Systems Induced by Repeated Electroconvulsive Shock

Ming

Mains

Eipper

2002

Neuropsychopharmacology

View full text Add to dashboard Cite

“…Gombos et al [18] did not see any significant reduction in the number of cells in the hip poeampus after electric shocks. Nonetheless, activation of neurogenesis in the hippocampus as a result of electric shocks [29,40] may be a compensatory response to neuron death, as described in other situations.…”

Section: Data On Selective Cell Death In the Brain In Conditionsmentioning

confidence: 90%

“…The question of the mechanisms of hippocampal cell death in convulsive activity also remains open, as some authors have described neuron death as a result of apopto sis, others as a result of necrosis [11,39,42,49]. On the other hand, the formation of new neurons in the hippocam pus (neurogenesis) has been described in conditions of con vulsion-evoked cell death [29,40,41], this evidently repre senting a repair (compensatory) process.…”

Section: Data On Selective Cell Death In the Brain In Conditionsmentioning

confidence: 99%

Electroconvulsive Shock Induces Neuron Death in the Mouse Hippocampus: Correlation of Neurodegeneration with Convulsive Activity

Zarubenko

Yakovlev

Stepanichev

et al. 2005

Neurosci Behav Physiol

View full text Add to dashboard Cite

The relationship between convulsive activity evoked by repeated electric shocks and structural changes in the hippocampus of Balb/C mice was studied. Brains were fixed two and seven days after the completion of electric shocks, and sections were stained by the Nissl method and immunohistochemically for apop totic nuclei (the TUNEL method). In addition, the activity of caspase-3, the key enzyme of apoptosis, was measured in brain areas immediately after completion of electric shoeks. The number of neurons decreased significantly in fIeld CAl and the dentate fascia, but not in hippocampal field CA3. The num bers of cells in CAl and CA3 were inversely coudated with the intensity of convulsions. Signs of apop totic neuron death were not seen, while caspase-3 activity was significantly decreased in the hippocampus after electric shocks. These data support the notion that functional changes affect neurons after electric shock and deepen our understanding of this view, providing direct evidence that there are moderate (up to 10%) but significant levels of neuron death in defined areas of the hippocampus. Inverse correlations of the numbers of cells with the extent of eonvulsive activity suggest that the main cause of neuron death is convulsions evoked by electric shocks.

show abstract

Increased neurogenesis in a model of electroconvulsive therapy

Abstract: Background: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry

Cited by 671 publications

References 34 publications

Regulation of Adult Neurogenesis by Antidepressant Treatment

Regulation of Adult Neurogenesis by Antidepressant Treatment

Plasticity in Hippocampal Peptidergic Systems Induced by Repeated Electroconvulsive Shock

Electroconvulsive Shock Induces Neuron Death in the Mouse Hippocampus: Correlation of Neurodegeneration with Convulsive Activity

Contact Info

Product

Resources

About