Increased neuropeptide Y concentrations in cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage.

Suzuki, Yoshinobu; Sato, Sigeru; Suzuki, Hitoshi; Namba, Jennifer; Ohtake, Ryusuke; Hashigami, Yoshihisa; Suga, Shin Ichi; Ishihara, Naoki; Shimoda, Shin-Ichi

doi:10.1161/01.str.20.12.1680

Cited by 33 publications

(17 citation statements)

References 34 publications

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“…In contrast to NPY-that was significantly increased in both serum and CSF in almost equal proportion (Schebesch et al, 2013a;Suzuki et al, 1989;Uemura et al, 1987), the levels of CGRP in serum were inversely proportional to the levels of CGRP in Cerebrospinal Fluid (CSF). The levels of CGRP in CSF had been examined before by Juul et al (1995).…”

Section: Discussionmentioning

confidence: 96%

Calcitonin Gene-Related Peptide in Serum After Spontaneous Subarachnoid Hemorrhage

Schebesch¹

2014

American Journal of Neuroscience

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Endogenous Calcitonin Gene-Related Peptide (CGRP) stored in perivascular nerve fibers around the cerebral arteries mediates vasodilation and regulates cerebral blood flow under physiological conditions. Increased levels of CGRP have been continually reported in patients with migraine, but the role of CGRP in the pathophysiology of Subarachnoid Hemorrhage (SAH) has not yet been sufficiently evaluated. Over 10 days, serum was prospectively collected from 33 consecutive patients (17 women, 16 men; mean age 52.8 years) with spontaneous non-traumatic SAH. All patients were graded III or IV according to the Fisher Score. CGRP levels were determined by means of an Enzyme-Immunosorbent Assay (EIA). CGRP concentrations were correlated to (1) the anatomical localization of the aneurysm (anterior circulation or posterior circulation), (2) the treatment modality (clipped group, coiled group, or untreated group) and (3) the rate of ischemia determined by computed tomography (ischemia group, non-ischemia group, or iatrogenic ischemia group). (1) Anatomical localization: CGRP levels were significantly higher in patients with a ruptured aneurysm of the anterior circulation (p<0.001). (2) Treatment modality: CGRP levels differed significantly between the groups (coil group, clip group, or untreated group; p<0.001). The highest levels of CGRP were detected in the coil group and the lowest levels in the untreated group. About (3) Ischemia: CGRP levels differed significantly between the three groups (ischemia group, non-ischemia group, or iatrogenic ischemia group; p = 0.038). The highest levels of CGRP were found in the ischemia group. The maximum levels of CGRP in serum were found for patients with a ruptured aneurysm of the anterior circulation and subsequent ischemia treated by endovascular coiling. These findings support the theory that CGRP is produced and excessively released to counteract cerebral vasospasm and subsequent ischemia. Presumably, the serum levels of CGRP are affected by the anatomical localization of the aneurysm and can be stimulated by any endoluminal manipulation of the parent artery.

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Section: Discussionmentioning

confidence: 96%

Calcitonin Gene-Related Peptide in Serum After Spontaneous Subarachnoid Hemorrhage

Schebesch¹

2014

American Journal of Neuroscience

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“…1) The excessive release of NPY into the subarachnoid spaces and its accumulation in CSF after SAH has been observed previously. 9,34 Presumably, this excess is caused by the disruption of NPY-containing nerve fibers at the moment of aneurysmal hemorrhage and the subsequent block of NPY re-uptake. 32 In contrast, some authors evaluating the levels of neuropeptides in CSF due to SAH found no evidence for excessive NPY exposition.…”

Section: Major Findingsmentioning

confidence: 99%

Neuropeptide Y – an early biomarker for cerebral vasospasm after aneurysmal subarachnoid hemorrhage

Schebesch

Brawanski

Bele

et al. 2013

Neurological Research

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“…[8][9][10] Because of NPY's potent vasoconstrictor properties, it has been suggested to be a regulator of cerebral blood flow (CBF) as well as a factor in cerebral vasospasm and DCI. 9 During the 1990s, several animal studies [11][12][13][14][15][16] and clinical studies [17][18][19][20][21] investigated the possible relationship between SAH, DCI, vasospasm, and NPY. However, conflicting results from these studies discouraged further NPY-related research for nearly a decade.…”

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confidence: 99%

High Plasma Levels of Neuropeptide Y Correlate With Good Clinical Outcome But are not Correlated to Cerebral Blood Flow or Vasospasm After Subarachnoid Hemorrhage

Rasmussen

Stavngaard

Jessing

et al. 2016

Journal of Neurosurgical Anesthesiology

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Increased neuropeptide Y concentrations in cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage.

Cited by 33 publications

References 34 publications

Calcitonin Gene-Related Peptide in Serum After Spontaneous Subarachnoid Hemorrhage

Calcitonin Gene-Related Peptide in Serum After Spontaneous Subarachnoid Hemorrhage

Neuropeptide Y – an early biomarker for cerebral vasospasm after aneurysmal subarachnoid hemorrhage

High Plasma Levels of Neuropeptide Y Correlate With Good Clinical Outcome But are not Correlated to Cerebral Blood Flow or Vasospasm After Subarachnoid Hemorrhage

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