Increased neuropilin-1 expression by COVID-19: a possible cause of long-term neurological complications and progression of primary brain tumors

Zalpoor, Hamidreza; Shapourian, Hooriyeh; Akbari, Abdullatif; Shahveh, Shaghayegh; Haghshenas, Leila

doi:10.1007/s13577-022-00716-2

Cited by 25 publications

(24 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glioblastoma multiforme (GBM) is a malignant tumor of connective tissue, and has been known as the most deadly primary brain tumor [ 1 , 39 – 41 ]. Flavonoids such as quercetin are able to cross the blood–brain barrier (BBB) via different mechanisms, including carrier-mediated transcellular transport transcellular diffusion or paracellular distribution via tight junctions between BBB endothelial cells [ 1 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

et al. 2022

Self Cite

View full text Add to dashboard Cite

The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses. Some of these processes can contribute to cancer progression and neurodegeneration. Owing to the complexity of this pathway and its potential crosstalk with alternative pathways, monotherapy as targeted therapy has usually limited long-term efficacy. Currently, the majority of JAK–STAT-targeting drugs are still at preclinical stages. Meanwhile, a variety of plant polyphenols, especially quercetin, exert their inhibitory effects on the JAK–STAT pathway through known and unknown mechanisms. Quercetin has shown prominent inhibitory effects on the JAK–STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases. This review discusses the pharmacological effects of quercetin on the JAK–STAT signaling pathway in solid tumors and neurodegenerative diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Coronavirus Disease 2019 (COVID-19) is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and affects billions of people around the world [ 1 – 7 ]. SARS-CoV-2 has been increasingly reported to attack not only the respiratory system and lead to respiratory complications [ 8 ] but also the central nervous system (CNS), causing neurological symptoms [ 9 – 12 ], and progression of multiple cancers [ 13 , 14 ]. According to retrospective investigations, 36.4% of SARS-CoV-2-infected individuals presented neurological manifestations such as acute cerebrovascular diseases, disturbed consciousness, and paresthesia [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Hypoxia‐inducible factor 1 alpha (HIF‐1α) stimulated and P2X7 receptor activated by COVID-19, as a potential therapeutic target and risk factor for epilepsy

et al. 2022

Self Cite

View full text Add to dashboard Cite

Based on available evidence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a neuroinvasive virus. According to the centers for disease control and prevention (CDC), coronavirus disease 2019 (COVID-19) may cause epilepsy. In this line, COVID-19 can stimulate hypoxia-inducible factor-1 alpha (HIF-1α) and activate P2X7 receptor. Both HIF-1α and P2X7 receptors are linked to epileptogenesis and seizures. Therefore, in the current study, we suggested that COVID-19 may have a role in epileptogenesis and seizure through HIF-1α stimulation and P2X7 receptor activation. Consequently, pharmacological targeting of these factors could be a promising therapeutic approach for such patients.

show abstract

“…On the other hand, hesperetin exerts a critical role in anti-cancer mechanisms against various cancer cells such as glioblastoma, breast, lung, pancreatic, liver, prostate, colon, kidney, oral, esophageal, osteosarcoma, ovarian, thyroid, and leukemia (Sohel et al 2022 ). On the other hand, multiple studies revealed that COVID-19 can lead to the progression of multiple diseases and cancers, so we addressed some cellular and molecular mechanisms in some of these studies (Zalpoor et al 2022a , b , c , d , e , f , g ). Moreover, multiple studies have confirmed the absence of adverse side effects after oral intake and the overall high safety profile of hesperidin, this flavanone might be useful as a prophylactic (Jose and Manuel 2020 ; Parisi et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways

et al. 2022

Self Cite

View full text Add to dashboard Cite

Hesperetin, an aglycone metabolite of hesperidin with high bioavailability, recently gained attention due to its anti-COVID-19 and anti-cancer properties. Multiple studies revealed that cancer patients are prone to experience a severe form of COVID-19 and higher mortality risk. In addition, studies suggested that COVID-19 can potentially lead to cancer progression through multiple mechanisms. This study proposes that hesperetin not only can be used as an anti-COVID-19 agent but also can reduce the risk of multiple cancer progression by suppressing several intracellular signaling pathways in cancer patients with COVID-19. Therefore, in this review, we attempted to provide evidence demonstrating anti-COVID-19/cancer properties of hesperetin with several mechanisms.

show abstract

Increased neuropilin-1 expression by COVID-19: a possible cause of long-term neurological complications and progression of primary brain tumors

Cited by 25 publications

References 17 publications

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Hypoxia‐inducible factor 1 alpha (HIF‐1α) stimulated and P2X7 receptor activated by COVID-19, as a potential therapeutic target and risk factor for epilepsy

Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways

Contact Info

Product

Resources

About