Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma

Park, Hae‐Sim; Uh, Soo Taek; Park, Choon-Sik

doi:10.3904/kjim.1996.11.1.69

Cited by 14 publications

(3 citation statements)

References 23 publications

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“…The authors mentioned that challenge with the flux caused a late reaction and an increase in nonspecific bronchial hyperresponsiveness. A recent report documented asthmatic reactions after inhalation challenge with aluminium powder and AlCI 3 solution in a safe manufacturing worker [18]. Work-related asthma has also been described in factories producing aluminium salts [5].…”

Section: Discussionmentioning

confidence: 99%

Occupational asthma caused by aluminium welding

Vandenplas¹,

Delwiche²,

Vanbilsen³

et al. 1998

Eur Respir J

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Occupational asthma has been documented in workers exposed to various metals, including platinum, chromium, cobalt, nickel and zinc [1,2]. Work-related asthma has been described in aluminium smelters [3,4] and in workers exposed to aluminium salts [5,6], although the exact aetiological agent has not yet been identified.We investigated a subject experiencing asthma on exposure to aluminium welding, whose inhalation challenges and environmental assessments provided evidence that aluminium was the most likely causal agent. Case reportA 32 yr old man had been employed as a maintenance worker in a leather plant. He had to perform electric arc welding on mild steel, using manual metal arc and inert gas metal arc techniques. Approximately once a month, he welded aluminium pieces using a manual metal arc process with a flux-coated electrode. After 4 yrs of intermittent exposure to these various welding processes, he developed chest tightness and wheezing that occurred specifically on days he welded on aluminium. Asthmatic symptoms started 1-4 h after the end of exposure to aluminium welding and persisted for several hours. The subject never experienced myalgia, chills or fever. He was treated with inhaled budesonide (400 µg daily) and salbutamol when necessary.The subject was referred for investigation 18 months after the onset of work-related asthmatic symptoms. At that time, he was experiencing asthma on exercise. He had smoked five cigarettes·day -1 for 12 yrs and reported a history of allergic rhinitis since childhood. Skin-prick tests with a battery of common inhalant allergens elicited a positive reaction to mixtures of tree, grass and weed pollens. Skintesting with Al(SO 4 ) 3 , Al(NO 3 ) 3 , Cr 2 (SO 4 ) 3 and NiSO 4 yielded negative results using concentrations of 0.01, 0.1, 1 and 10 mg·mL -1 in saline. Inhalation challengesInhalation challenges were performed in the hospital workshop, according to recent guidelines [7]. Baseline spirometric measurements showed a forced expiratory volume in one second (FEV1) of 4.38 L (100% predicted value) and a FEV1/forced vital capacity (FVC) ratio of 73% (89% pred). On a control day without exposure to occupational agents, spontaneous fluctuations of FEV1 were <10% ( fig. 1a). At the end of the control day, the provocative concentration of histamine causing a 20% fall in FEV1 (PC20) was 0.07 mg·mL -1 [8]. The next day, manual metal arc welding on aluminium for 1 h with the fluxcoated electrodes used at work resulted in a transient fall in FEV1, with a maximum of 17% that was recorded 7 h after the end of exposure. On the following day, exposure to aluminium welding for 2 h provoked an asthmatic reaction with a progressive fall in FEV1, reaching 52% at 2 h postexposure. The subject was given inhaled salbutamol (200 µg) at that time and again 4 h later. On the next morning, FEV1 was still 20% lower than pre-exposure value, so that histamine PC20 was not reassessed.The subject gave informed consent for additional inhalation challenges. One month after the first set of tests, h...

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Section: Discussionmentioning

confidence: 99%

Occupational asthma caused by aluminium welding

Vandenplas¹,

Delwiche²,

Vanbilsen³

et al. 1998

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…OA has previously been described in smelters and welders in the aluminum industry, as well as in factories producing aluminum salts [4][5][6]. Exposure to fluorides or aminoethyl ethanolamine have been reported to be possible causes of reactions in aluminum smelters [4,6], and several data show that aluminum can cause asthmatic reactions even in the absence of these products [4,7]. To our knowledge, OA induced by exposure to aluminum hydroxide has not previously been reported.…”

mentioning

confidence: 79%

Occupational Asthma Caused by Powder Paint in the Automotive Industry

Tiotiu

Thaon

Mathias

et al. 2019

J Investig Allergol Clin Immunol

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“…When used as short‐term topical therapy for hyperhidrosis, aluminum preparations are thought to obstruct the eccrine duct and possibly alter the glandular secretory function (10). Aluminum powder and aluminum chloride have also been reported to increase neutrophil chemotactic activity during inhalational challenge testing of aluminum‐induced occupational asthma (11). Nevertheless, we found no reports associating either aluminum dust or aluminum chloride with RPPH.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Palmoplantar Hidradenitis with Exclusive Palmar Involvement and an Association with Trauma and Exposure to Aluminum Dust

Shehan

Clowers-Webb

Kalaaji

2004

Pediatric Dermatology

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Recurrent palmoplantar hidradenitis is a benign, self-limited inflammatory skin condition that has been reported to occur on the soles and palms of otherwise healthy children and young adults. Patients with the disease present with tender, erythematous and edematous plaques and nodules on the palmoplantar skin. We describe a child who had recurrent palmoplantar hidradenitis that occurred after trauma and exposure to aluminum dust and manifested as lesions localized to only the palmar surfaces. This case is presented to add exclusive palmar involvement to the diagnostic spectrum of recurrent palmoplantar hidradenitis and to review the proposed pathogenesis of the disease.

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Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma

Cited by 14 publications

References 23 publications

Occupational asthma caused by aluminium welding

Occupational asthma caused by aluminium welding

Occupational Asthma Caused by Powder Paint in the Automotive Industry

Recurrent Palmoplantar Hidradenitis with Exclusive Palmar Involvement and an Association with Trauma and Exposure to Aluminum Dust

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