Increased neutrophil-lymphocyte ratios in depressive adolescents is correlated with the severity of depression

Özyurt, Gonca; Binici, Nagihan Cevher

doi:10.1016/j.psychres.2018.08.007

Cited by 46 publications

(41 citation statements)

References 63 publications

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“…As R‐SDS increased neutrophils and decreased B cells to different extents in the blood of the two mouse strains with different stress susceptibility, but similarly in susceptible and resilient mice, these leukocyte changes could represent genetic variability of stress susceptibility and mediate gene–environment interaction in stress‐related pathology. Clinical studies have reported an increase in circulating neutrophils in depressive patients that is correlated to the severity of depressive symptoms (see Lynall et al, 2020; Özyurt & Binici, 2018). Given the association of circulating neutrophils and stress‐induced behavioural changes in this study, it is intriguing to test whether neutrophil increase in depressive patients reflects the state of stress and contributes to depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain‐dependent difference in response

Ishikawa

Kitaoka

Kawano

et al. 2020

British J Pharmacology

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Background and Purpose Inflammation has been associated with stress‐related mental disturbances. Rodent studies have reported that blood‐borne cytokines are crucial for stress‐induced changes in emotional behaviours. However, the roles and regulation of leukocytes in chronic stress remain unclear. Experimental Approach Adult male C57BL/6N mice were subjected to repeated social defeat stress (R‐SDS) with two protocols which differed in stress durations, stress cycles, and housing conditions, followed by the social interaction test. The numbers of leukocyte subsets in the bone marrow, spleen, and blood were determined by flow cytometry shortly after or several days after R‐SDS. These leukocyte changes were studied in two strains of mice with different stress susceptibility, C57BL/6N and BALB/c mice. Key Results R‐SDS with both protocols similarly induced social avoidance in C57BL/6N mice. In the bone marrow, neutrophils and monocytes were increased, and T cells, B cells, NK cells, and dendritic cells were decreased with both protocols. In the blood, neutrophils and monocytes were increased with both protocols, whereas T cells, B cells, NK cells, and dendritic cells were decreased with one of these. Neutrophils and monocytes were also increased in the spleen. Changes in the bone marrow and increased levels of circulating neutrophils were maintained for 6 days after R‐SDS. BALB/c mice showed greater social avoidance and increase in circulating neutrophils than C57BL/6N mice. Conclusion and Implications In two strains of mice, chronic stress induced neutrophil mobilization and its maintenance. These effects were strain‐related and may contribute to the pathology of mental illness. LINKED ARTICLES This article is part of a themed issue on Neurochemistry in Japan. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.4/issuetoc

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Section: Discussionmentioning

confidence: 99%

Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain‐dependent difference in response

Ishikawa

Kitaoka

Kawano

et al. 2020

British J Pharmacology

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“…It has also been reported that NLR value is signifi cantly higher in psychiatric disorders such as schizophrenia, bipolar and depressive disorders in adults, as compared to the control group (16)(17)(18). In addition, an elevation in the neutrophil lymphocyte ratio has been shown to be present in child and adolescent psychiatric diseases (19,20).…”

Section: Introductionmentioning

confidence: 95%

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

Uzun¹

2021

BLL

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AIM: This study aims to investigate whether there is a relationship between attention-defi cit/hyperactivity disorder (ADHD) and infl ammation, using hematologic infl ammatory parameters in a large sample of children and adolescents. METHOD: This retrospective study comprises 347 children and adolescents with ADHD between 6 and 17 years of age who met the inclusion criteria as well as 205 healthy children and adolescents in the control group. Serum parameters such as white blood cell (WBC), neutrophil, lymphocyte, platelet, monocyte, eosinophil and basophil counts, mean platelet volume (MPV), and platelet distribution width (PDW) were recorded from complete blood count tests at the time of admission, while neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and other ratios were calculated based on these counts. RESULTS: NLR, PLR, MPV, PDW, WBC and neutrophil counts were signifi cantly higher in children and adolescents with ADHD than in the control group. In the ADHD group, NLR, WBC and neutrophil counts were signifi cantly higher in girls than in boys. CONCLUSIONS: The results of this study support the hypothesis that infl ammation plays an important role in the complex pathophysiology of ADHD. In addition, our data confi rm that easily obtainable and reliable hematological parameters can be used when investigating the role of infl ammation in ADHD etiology (Tab. 4, Ref.

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“…Erişkin depresyon hastaları depresyonun şiddetine göre sınıflandırıldığında psikotik özellikli depresyonda hafif, orta ve ağır şiddetli depresyona göre daha yüksek PLO değerleri tespit edilmiştir (28). Ergen depresyon hastalarında ise NLO değeri kontrol grubundan daha yüksek düzeyde saptanmıştır (29) This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.…”

Section: Please Cite This Article As: Ozdin S Bayrak Ozdin S Do Latunclassified

Do late and early onset depression differ in terms of inflammation?

Özdin¹,

Özdin²

2020

Dusunen Adam

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Increased neutrophil-lymphocyte ratios in depressive adolescents is correlated with the severity of depression

Cited by 46 publications

References 63 publications

Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain‐dependent difference in response

Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain‐dependent difference in response

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

Do late and early onset depression differ in terms of inflammation?

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