Increased nuchal translucency and adverse pregnancy outcomes

Shakoor, Shafia; Dileep, Dhanwanti; Tirmizi, Summera; Rashid, Sadia; Amin, Yasmin; Munim, Shama

doi:10.1080/14767058.2016.1224836

Cited by 18 publications

(12 citation statements)

References 17 publications

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“…Nuestros resultados son similares a los de Shakoor (12) , quien reporta 18 fetos con TN ≥ 5,5 mm, de los cuales 2 nacieron vivos, 7 murieron in-traútero, 8 interrupciones y una muerte neonatal; pero, difieren en que en su serie solo 3/13 fetos con TN ≥ 6,5 mm se realizaron cariotipo prenatal y dos de ellos tuvieron cariotipo normal.…”

Section: Resultsunclassified

Pronóstico de la translucencia nucal fetal ≥ 5,5 mm en Lima, Perú

Chang¹,

Diez²

2019

Rev peru ginecol obstet.

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Introducción. El tamizaje ecográfico del primer trimestre se realiza en el Perú desde hace 19 años, pero se carece de información del seguimiento de las pacientes evaluadas. Objetivos. Determinar el pronóstico de una translucencia nucal (TN) muy aumentada en el feto. Diseño. Estudio retrospectivo observacional. Pacientes. Se evaluó 10 340 fetos consecutivos entre las 11 y 13 semanas, en madres que llegaron al servicio de ecografía. Intervenciones. Evaluación por nueve ecografistas acreditados por la Fetal Medicine Foundation (FMF) siguiendo las recomendaciones de la FMF. Los resultados fueron registrados en el software Astraia. Resultados. Treintaisiete (0,36%) pacientes tuvieron TN ≥ 5,5 mm; ocho no regresaron a la institución y se desconoce el desenlace de su embarazo, por lo que no fueron considerados en el análisis posterior. De los 29 reportados, en 18 se realizó cariotipo prenatal, 17 de ellos fueron anormales (7 trisomías 21; 4 trisomías 18; 5 monosomías X; una trisomía 22). Cuatro de los 7 fetos con trisomía 21 nacieron a término sin malformaciones importantes; uno falleció durante el embarazo, otro embarazo fue interrumpido en el extranjero y se desconoce el desenlace de un caso. De los 11 que no se realizaron cariotipo prenatal, uno (3,2%) nació vivo y sano y los otros 10 fallecieron durante el embarazo. Diecisiete cariotipos de 19 conocidos fueron anormales, lo que difiere significativamente de los resultados de Kagan (89% vs 64%, p<0,05). Conclusiones. El pronóstico de los fetos con TN ≥5,5 mm en nuestra institución fue significativamente peor que el publicado en la literatura.

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Section: Resultsunclassified

Pronóstico de la translucencia nucal fetal ≥ 5,5 mm en Lima, Perú

Chang¹,

Diez²

2019

Rev peru ginecol obstet.

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“…Therefore, our data show that NT measurements within normal limits can be useful parameters for detecting future macrosomic or LGA fetuses. It has been emphasized in the literature that increased NT measurements (normal chromosomes and no structural anomalies) are associated with negative outcomes such as SGA, intrauterine growth restriction, and preterm labor in euploid fetuses (15,32).…”

Section: Discussionmentioning

confidence: 99%

“…Low maternal serum PAPP-A in the first trimester has an association with adverse pregnancy outcomes particularly if levels are very low (<1 st centile) (14). Increased NT has also been associated with poor obstetric outcomes, such as a decrease in PAPP-A (15). Nevertheless, the association between a low β -hCG level in the second trimester and adverse obstetric outcomes has been controversial (16).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Soysal

Bıyık

Erten

et al. 2021

Gynecol Obstet Reprod Med

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OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

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“…Several studies have demonstrated that increased nuchal translucency (INT) is strongly associated with fetal cytogenetic disorders [1][2][3][4][5], especially trisomy 21 or 45, XO, and some specific fetal anomalies, in particular cardiac defects [3,6,7]. Additionally, INT in euploid fetuses or unexplained INT has been reported to be associated with various poor obstetric outcomes [8][9][10][11][12][13], including spontaneous abortion, low birth weight, preterm birth, fetal growth restriction, gestational diabetes mellitus, and preeclampsia. Nevertheless, most studies concerning effectiveness of NT measure-ments as a screening test of chromosome abnormalities or fetal cardiac defects are confined to the western world, the outcomes of NT screening in developing countries being reported rarely.…”

Section: Introductionmentioning

confidence: 99%

Increased nuchal translucency and fetal outcomes: a population-based study in Thailand

Traisrisilp¹,

Sirichotiyakul²,

Tongprasert³

et al. 2021

Clin. Exp. Obstet. Gynecol.

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Background: To determine the association between increased nuchal translucency (INT) and fetal outcomes among Thai population. Methods: A prospective database of fetal Down syndrome screening project was accessed to enable retrieval of the records of any women with recorded NT measurements. The selected pregnancies were categorized into the INT group (>95th percentile) and the normal (<95th percentile) group. The effectiveness of NT for prediction of Down syndrome and hemoglobin Bart's disease was also determined. Pregnancy outcomes were compared, also using multivariate analysis to correct the major confounders. Results: Out of 8225 NT measurements recorded, data from 7126 fetuses were available for analysis. These included 357 in the INT group and 6769 in the normal group. INT was significantly associated with Turner syndrome, Down syndrome, Edwards' syndrome, Patau syndrome, cardiac defect and Hb Bart's disease. After exclusion of fetal abnormalities, rates of abortion, low birth weight (LBW), preterm birth and intrauterine death (IUD) were significantly higher in the INT group, with adjusted odds ratio (95% CI) of 7.82 (7.48-13.66), 0.60 (0.42-0.86) and 5.10 (1.11-23.42), respectively. INT was effective in predicting Down syndrome with a sensitivity of 61.1% with a false positive rate of 5%. Conclusions: In addition to effectiveness in screening aneuploidy and cardiac defect, INT significantly increased the identification of risk of some diseases specific to a certain geographical area, for example Hb Bart's disease in Thailand. Among the euploid fetuses in this study the rate of abortion, LBW, preterm birth and IUD were also significantly increased.

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Increased nuchal translucency and adverse pregnancy outcomes

Abstract: Raised Nuchal translucency measurement is associated with adverse pregnancy outcome. One in three fetuses are affected by it. Live birth in this group where there is no aneuploidy is around 3.7%.

Cited by 18 publications

References 17 publications

Pronóstico de la translucencia nucal fetal ≥ 5,5 mm en Lima, Perú

Pronóstico de la translucencia nucal fetal ≥ 5,5 mm en Lima, Perú

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Increased nuchal translucency and fetal outcomes: a population-based study in Thailand

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