Increased Number of Circulating Progenitor Cells After Implantation of Ventricular Assist Devices

Manginas, Athanassios; Tsiavou, Anastasia; Sfyrakis, Petros; Giamouzis, Grigorios; Tsourelis, L.; Leontiadis, Evangelos; Degiannis, Dimitrios; Cokkinos, Dennis V.; Alivizatos, Peter A.

doi:10.1016/j.healun.2009.04.006

Cited by 30 publications

(21 citation statements)

References 48 publications

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“…In a recent study, Jahanyar et al [38] have demonstrated that LVADs cause a significant increase of stem cell factor and its receptor (c-kit) gene expression, which coincided with a surge of mast cells after ventricular unloading. In another study [39] , a significant increase in EPCs was also reported after LVAD implantation.…”

Section: Devicesmentioning

confidence: 76%

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Circulating endothelial and progenitor cells: Evidence from acute and long-term exercise effects

Koutroumpi¹

2012

WJC

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Circulating bone-marrow-derived cells, named endothelial progenitor cells (EPCs), are capable of maintaining, generating, and replacing terminally differentiated cells within their own specific tissue as a consequence of physiological cell turnover or tissue damage due to injury. Endothelium maintenance and restoration of normal endothelial cell function is guaranteed by a complex physiological procedure in which EPCs play a significant role. Decreased number of peripheral blood EPCs has been associated with endothelial dysfunction and high cardiovascular risk. In this review, we initially report current knowledge with regard to the role of EPCs in healthy subjects and the clinical value of EPCs in different disease populations such as arterial hypertension, obstructive sleep-apnea syndrome, obesity, diabetes mellitus, peripheral arterial disease, coronary artery disease, pulmonary hypertension, and heart failure. Recent studies have introduced the novel concept that physical activity, either performed as a single exercise session or performed as part of an exercise training program, results in a significant increase of circulating EPCs. In the second part of this review we provide preliminary evidence from recent studies investigating the effects of acute and long-term exercise in healthy subjects and athletes as well as in disease populations.

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Section: Devicesmentioning

confidence: 76%

“…In the study of Jahanyar et al [38] the patients' EPCs were compared to tru-cut biopsies of donor hearts, while in the study of Manginas et al [39] , the control group comprised patients who were ineligible for LVAD implantation.…”

Section: Devicesmentioning

confidence: 99%

Circulating endothelial and progenitor cells: Evidence from acute and long-term exercise effects

Koutroumpi¹

2012

WJC

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“…Recently, we suggested a possible role of circulating CD34+ in severe CHF, after VAD implantation. We described a significant increase of CD34+ cells in VAD-treated patients and a reduction of these cells in the non-VAD-treated patients [29]. The transient peripheral recruitment of CD34+ cells in the VAD-treated patients could probably represent a functional bone marrow response to the mechanical circulatory support, presumably leading to biological procedures that may accelerate the improvement of cardiac performance.…”

Section: Progenitor Cells and Mechanical Circulatory Supportmentioning

confidence: 79%

Dynamics of Progenitor Cells and Ventricular Assist Device Intervention

Tsiavou

Manginas

2009

J. of Cardiovasc. Trans. Res.

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Experimental and clinical evidence suggests that a heterogeneous group of bone-marrow-derived circulating progenitor cells, with variations in phenotype and function, provide an endogenous repair mechanism, contributing to vascular healing and remodeling under physiological and pathological conditions, such as cancer, atherosclerosis, myocardial infarction, and end-stage heart failure. Implantation of ventricular assist devices (VADs) for circulatory support is indicated in selected patients with end-stage heart failure as a bridge to heart transplantation, however seldom; improvement of ventricular contractility has been well documented with prolonged cardiac unloading. The current review summarizes recent findings from in vitro and in vivo studies, focusing on the biological features and the possible role of progenitor cells in the transient myocardial recovery, occasionally seen after VAD implantation, and speculates on their clinical utilities for the treatment of the failing human heart.

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“…Investigators of mechanical unloading through LVAD therapy have documented increases in circulating progenitor cells, 32 as well as myocardial gene expression of stem cell factor and the c-kit receptor. 33 Current trials of combined LVAD and stem cell therapy might yield further insights into the potential for myocardial recovery in selected patients.…”

Section: Myocardial Recovery and Adjunctive Therapymentioning

confidence: 99%

State of the Art of Mechanical Circulatory Support

Mallidi¹,

Anand

Cohn³

2014

Texas Heart Institute Journal

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Mechanical circulatory support of the failing heart has become an important means of treating end-stage heart disease. This rapidly growing therapeutic field has produced impressive clinical outcomes and has great potential to help thousands of otherwise terminal patients worldwide. In this review, we examine the state of the art of mechanical circulatory support: current practice, totally implantable systems of the future, evolving biventricular support mechanisms, the potential for myocardial recovery and adjunctive treatment methods, and miniaturized devices with expanded indications for therapy.

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Increased Number of Circulating Progenitor Cells After Implantation of Ventricular Assist Devices

Cited by 30 publications

References 48 publications

Circulating endothelial and progenitor cells: Evidence from acute and long-term exercise effects

Circulating endothelial and progenitor cells: Evidence from acute and long-term exercise effects

Dynamics of Progenitor Cells and Ventricular Assist Device Intervention

State of the Art of Mechanical Circulatory Support

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