Increased number of regulatory T cells (T-regs) in the peripheral blood of patients with Her-2/neu-positive early breast cancer

Abstract

Increased numbers of circulating T-regs may contribute to the higher metastatic potential of Her-2/neu-positive cells. A potential role as a prognostic or predictive parameter is currently being analyzed in a larger cohort of patients with sufficient follow-up.

The correlation of CD19 + CD24 + CD38 + B cells and other clinicopathological variables with the proportion of circulating Tregs in breast cancer patients

“…In this study, first we focused on breast cancer and examined the percentage of T and B regulatory cells and compared them with healthy individuals. As we expected and similar to the result of other studies [12,29], the breast cancer patients had a significantly elevated percentage of circulating CD4 ? CD25 ?-FoxP3 ?…”

“…Previous studies have shown an increased circulating Tregs in HER2 amplified patients [12,29]. In this study, we also observed a significant increase in circulating Tregs of HER2 amplified patients.…”

“…Another study also demonstrated that there is no association between circulating Tregs and tumor grade [12]. Since there was a low population of patients with negative hormone receptor and it was not statistically valuable, we did not include hormone receptors in our model analysis.…”

“…In addition, their ability to mediate suppression of cancer's immune response is increasingly recognized [9,10] and studies have found that Tregs play important roles in tumor scape [11]. Elevated proportion of Tregs is present within tumors, lymph nodes and peripheral blood of various types of solid and hematologic cancers including breast cancer [12,13]. Besides, frequency of CD4 ?…”

Effects of Gastric Cancer Cells on the Differentiation of Treg Cells

“…Patients and experimental models with cancer showed that Treg cells down-regulated the activity of effector function against tumors, resulting in T-cell dysfunction in cancerbearing hosts (Weiss et al, 2012;Sakuishi et al, 2013). An increased population of Treg cells was reported in patients with ovarian cancer (Wicherek et al, 2011), lung cancer (Erfani et al, 2012), and breast cancer (Decker et al, 2012). However, there are no previous reports describing Treg cells in gastric cancer.…”