2019
DOI: 10.1101/672055
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Increased O-GlcNAcylation rapidly decreases GABAAR currents in hippocampus yet depresses neuronal output

Abstract: O-GlcNAcylation, a post-translational modification involving O-linkage of β-N-acetylglucosamine to Ser/Thr residues on target proteins, is increasingly recognized as a critical regulator of brain function in health and disease. Enzymes that catalyze O-GlcNAcylation are found at both presynaptic and postsynaptic sites, and O-GlcNAcylated proteins localize to synaptosomes. Acute increase in O-GlcNAcylation induces long-term depression (LTD) of excitatory transmission at hippocampal CA3-CA1 synapses, and depresse… Show more

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