Increased odds and predictive rates of MMPI-2-RF scale elevations in patients with psychogenic non-epileptic seizures and observed sex differences

Bene, Victor A. Del; Rentería, Miguel Arce; Maiman, Moshe; Slugh, Mitchell; Gazzola, Deana M.; Nadkarni, Siddhartha; Barr, William

doi:10.1016/j.yebeh.2017.04.023

Cited by 21 publications

(5 citation statements)

References 43 publications

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“…16 Patients with FS had an elevated hypochondriasis subscore on the Minnesota Multiphasic Personality Inventory-2, which can signify a propensity toward somatic complaints including heightened sensitivity to injury. 37,38 However, this hypothesis was not supported by our data, where we did not find a difference in attribution of seizure cause between patients with FS and ES. Overall attribution of seizures to TBI was low across patient groups.…”

Section: Discussioncontrasting

confidence: 84%

Self-Reported Severity and Causes of Traumatic Brain Injury in Patients With Epileptic or Functional Seizures

et al. 2022

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Abstract:Background:While moderate and severe traumatic brain injury (TBI) can cause post-traumatic epilepsy, many patients with functional seizures (FS) also report a history of mild TBI. To determine if features of TBI history differs between patients with epileptic seizures (ES) and FS, we compared patient reports of TBI severity, symptoms, and causes of injury.Methods:We recruited patients undergoing video-EEG evaluation for diagnosis of ES, FS, mixed ES and FS, or physiologic seizure-like events at an academic, tertiary referral center. Patients and their caregivers were interviewed prior to final video-EEG diagnosis regarding their TBI histories, including concussive symptoms and causes of injury.Results:Of 506 patients, a greater percentage of patients with FS reported a history of TBI than patients with ES (70% vs 59%, aOR=1.75 [95% confidence interval: 1.00-3.05], p=0.047). TBI with loss of consciousness (LOC) lasting less than 30 minutes was more frequently reported among patients with functional seizures than with ES (27% vs 13%, aOR=2.38 [1.26-4.47], p<0.01). The proportion of patients reporting other neurological symptoms immediately after TBI was not significantly different between FS and ES (40% vs 29%, p=0.08). Causes of TBI were found to differ, with TBIs caused by falls from a height (17% vs 10%, aOR=2.24 [1.06-4.70], p=0.03) or motor vehicle collisions (27% vs 11%, aOR=2.96 [1.54-5.67], p<0.01) reported more frequently in FS than ES.Discussion:Our findings further the association of mild TBI with FS and prompt reconsideration of typical assumptions regarding the significance of reported TBI history in patients with previously undifferentiated seizures. While common in both groups, TBI with LOC less than 30 minutes and causes of injury that are commonly thought to be more severe were reported more frequently in FS than ES. This suggests that patient or caregiver reporting of these features does not imply post-traumatic epilepsy is a more probable diagnosis than FS. While history of TBI with LOC and presumed high-risk causes of injury intuitively raises suspicion for post-traumatic epilepsy, clinicians should be cautioned that these historical factors also were a frequent finding in patients with FS.

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Section: Discussioncontrasting

confidence: 84%

Self-Reported Severity and Causes of Traumatic Brain Injury in Patients With Epileptic or Functional Seizures

et al. 2022

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“…This data represents important supportive evidence adding to the diagnosis certainty of PNES [9]. Case in point, elevations in the frequency of somatic complaints by PNES patients on both the MMPI-2 and the MMPI-2-RF have been reported with somatic and somatic-depressive profiles indicative of PNES [10].…”

Section: Introductionsupporting

confidence: 60%

Diagnostic utility of the Minnesota multiphasic personality inventory-2 in patients diagnosed with psychogenic non-epileptic seizures in the Czech Republic

Krámská

Myers

Hrešková

et al. 2021

Epilepsy & Behavior

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The purpose of the present study is to examine the Minnesota Multiphasic Personality Inventory 2 (MMPI-2) scores of individuals diagnosed with psychogenic non-epileptic seizures (PNES) in a tertiary epilepsy center in the Czech Republic. Method: Patients (F:M 130:45; mean age 36.8 years; 12.7 years of education, frequency of seizures 0.37 per day, illness duration 5.75 years) were assessed while inpatients at the Epilepsy Center, Na Homolce Hospital, Prague. Patients underwent video-EEG testing and comprehensive neuropsychological testing and personality assessment which included the MMPI-2. Results: Elevated (+1.5SD) F and Back F (Fb) validity scales were observed along with elevated clinical scales Hypochondriasis (Hs), Depression (D), Hysteria (Hy), Psychasthenia (Pt), and Schizophrenia (Sc). Scores higher than 1 SD were found in Psychopathic Deviate (Pd), Paranoia (Pa), Hypomania (Ma) and Social Introversion (Si) scales and on validity scales True Response Inconsistency Scale (TRIN) and Variable Response Inconsistency Scale (VRIN). Conclusion: Patients diagnosed with PNES exhibit numerous elevations on the MMPI-2. Understanding the underlying psychological constructs of the patient with PNES more accurately improves predictive utility (for the presence of PNES) and allows the clinician to offer interventions that are more customized. Minnesota Multiphasic Personality Inventory results may be useful to exclude other possible diagnoses and to further determine the individual's characteristics that may be helpful when tailoring treatment, including psychotherapy.

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“…One exception was having had a history of a seizure, which did not yield meaningful correlations with scores on NUC, RC1, or MLS as expected. Prior research on the MMPI-2-RF that did identify such associations used samples of individuals who were being evaluated for and were formally diagnosed with epileptic seizures (i.e., Del Bene et al, 2017; Duncan et al, 2018; Locke et al, 2010). This unexpected finding will require replication and explication.…”

Section: Discussionmentioning

confidence: 99%

“…MMPI-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2011) studies in clinical neuropsychology settings have focused on the test’s utility for assessing symptoms related to seizures, head injuries, or alcohol-induced neurocognitive disorder 1 . For example, some studies have investigated the utility of MMPI-2-RF scale scores for differentiating between epileptic seizures and psychogenic nonepileptic seizures (Del Bene et al, 2017; Duncan et al, 2018; Locke et al, 2010) and describing psychological correlates of psychogenic nonepileptic seizures (e.g., Myers, Lancman, Laban-Grant, Matzner, & Lancman, 2012; Myers, Perrine, Lancman, Fleming, & Lancman, 2013; Nelson et al, 2011). Additional studies have examined MMPI-2-RF scores among patients with traumatic brain injuries (Goldsworthy & Donders, 2019), including military personnel (Arbisi, Polusny, Erbes, Thuras, & Reddy, 2011; Lippa, French, Bell, Brickell, & Lange, 2019; Mattson, Nelson, Sponheim, & Disner, 2019).…”

mentioning

confidence: 99%

Psychometric properties of the Minnesota Multiphasic Personality Inventory-3 (MMPI-3) in a clinical neuropsychology setting.

Whitman¹,

Tylicki²,

Mascioli³

et al. 2021

Psychological Assessment

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The Minnesota Multiphasic Personality Inventory (MMPI) instruments have a longstanding history of clinical applications in neuropsychological settings, and many studies have supported the utility of MMPI-2-Restructured Form scores among specific neuropsychological populations. However, the MMPI-3, a new version of the MMPI, has yet to be studied in a clinical neuropsychological setting. To address this need, we investigated the psychometric properties of MMPI-3 scores using a sample of 197 independent practice outpatient neuropsychology examinees (56.9% women; 80.2% White). Internal consistency coefficients and standard errors of measurement were generally consistent with statistics reported for two comparison groups included in the MMPI-3 Technical Manual, supporting the reliability of MMPI-3 scores. Correlations with external criteria-including presenting problems, neurocognitive, psychological/behavioral, and psychiatric diagnostic variables-supported the convergent and discriminant validity of MMPI-3 scores. Finally, relative risk analyses showed meaningful and theoretically expected findings, supporting the utility of the MMPI-3 in a clinical neuropsychological setting. Practical applications, study limitations, and future research directions are discussed. Public Significance StatementResults of this study support the psychometric properties-reliability, validity, and clinical utility-of Minnesota Multiphasic Personality Inventory-3 scale scores in a clinical neuropsychological setting. A wide range of external criteria were considered, including presenting problems, neurocognitive variables, psychological and behavioral variables, and psychiatric diagnoses.

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Increased odds and predictive rates of MMPI-2-RF scale elevations in patients with psychogenic non-epileptic seizures and observed sex differences

Cited by 21 publications

References 43 publications

Self-Reported Severity and Causes of Traumatic Brain Injury in Patients With Epileptic or Functional Seizures

Self-Reported Severity and Causes of Traumatic Brain Injury in Patients With Epileptic or Functional Seizures

Diagnostic utility of the Minnesota multiphasic personality inventory-2 in patients diagnosed with psychogenic non-epileptic seizures in the Czech Republic

Psychometric properties of the Minnesota Multiphasic Personality Inventory-3 (MMPI-3) in a clinical neuropsychology setting.

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