Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs

Butruille, Lucile; Sébillot, Anthony; Ávila, Katia; Vancamp, Pieter; Demeneix, Barbara; Pifferi, Fabien; Remaud, Sylvie

doi:10.1016/j.stemcr.2022.12.015

Cited by 1 publication

(1 citation statement)

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“…In mammals, the limited tissue repair results from the absence of evident neuronal precursors, a generally unfavorable tissue environment for neurogenesis, the presence of glial/fibrillar scars, and the exacerbation of chronic diseases [3]. It is particularly interesting that mammalian astrocytes, oligodendrocyte progenitors, and ependymal cells can be converted into progenitors able to produce glia and neurons, as this suggests that they have the potential to repair neurons [4,5]. For example, it has been shown that inactive astrocytes can, under physiological conditions, be converted into neurons in vitro and in vivo by regulating levels of Notch signaling or inducing the expression of proneural factors such as Neurod1.…”

Section: Introductionmentioning

confidence: 99%

Adult Neurogenesis of Teleost Fish Determines High Neuronal Plasticity and Regeneration

Pushchina,

Kapustyanov,

Kluka

2024

IJMS

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Studying the properties of neural stem progenitor cells (NSPCs) in a fish model will provide new information about the organization of neurogenic niches containing embryonic and adult neural stem cells, reflecting their development, origin cell lines and proliferative dynamics. Currently, the molecular signatures of these populations in homeostasis and repair in the vertebrate forebrain are being intensively studied. Outside the telencephalon, the regenerative plasticity of NSPCs and their biological significance have not yet been practically studied. The impressive capacity of juvenile salmon to regenerate brain suggests that most NSPCs are likely multipotent, as they are capable of replacing virtually all cell lineages lost during injury, including neuroepithelial cells, radial glia, oligodendrocytes, and neurons. However, the unique regenerative profile of individual cell phenotypes in the diverse niches of brain stem cells remains unclear. Various types of neuronal precursors, as previously shown, are contained in sufficient numbers in different parts of the brain in juvenile Pacific salmon. This review article aims to provide an update on NSPCs in the brain of common models of zebrafish and other fish species, including Pacific salmon, and the involvement of these cells in homeostatic brain growth as well as reparative processes during the postraumatic period. Additionally, new data are presented on the participation of astrocytic glia in the functioning of neural circuits and animal behavior. Thus, from a molecular aspect, zebrafish radial glia cells are seen to be similar to mammalian astrocytes, and can therefore also be referred to as astroglia. However, a question exists as to if zebrafish astroglia cells interact functionally with neurons, in a similar way to their mammalian counterparts. Future studies of this fish will complement those on rodents and provide important information about the cellular and physiological processes underlying astroglial function that modulate neural activity and behavior in animals.

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Section: Introductionmentioning

confidence: 99%