Increased oral inflammation, leukocytes, and leptin, and lower adiponectin in overweight or obesity

Thanakun, Supanee; Pornprasertsuk‐Damrongsri, Suchaya; Izumi, Yuichi

doi:10.1111/odi.12679

Cited by 26 publications

(18 citation statements)

References 49 publications

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“…On the other hand, leptin and resistin show proinflammatory activities. It has been demonstrated that, in overweight/obese individuals, adiponectin is reduced while both leptin and resistin are significantly increased . It is also reported that obese individuals present a constant proinflammatory state that may be responsible for the higher risk of infections, which includes periodontal diseases …”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that, in overweight/obese individuals, adiponectin is reduced while both leptin and resistin are significantly increased. 38 It is also reported that obese individuals present a constant proinflammatory state that may be responsible for the higher risk of infections, which includes periodontal diseases. 39 Additional to the systemic proinflammatory state, the psychosocial attitudes of obese individuals may negatively affect their oral hygiene practices, which may impair health of periodontal tissues.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Body fat rather than body mass index is associated with gingivitis – A southern Brazilian cross‐sectional study

Muniz

Costa

Cavagni

et al. 2018

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Body fat rather than body mass index is associated with gingivitis – A southern Brazilian cross‐sectional study

Muniz

Costa

Cavagni

et al. 2018

Journal of Periodontology

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“…It is prescribed for climacteric disorder, dysmenorrhea, neurosis, and in cancer supportive therapy [18,19]. Hormones and cytokines released from adipocytes are involved in the aggravation of diseases for which KSS is prescribed [20][21][22][23][24]. KSS reduces lipid accumulation in human hepatoma HepG2 cells in the presence of oleic acid [25].…”

Section: Introductionmentioning

confidence: 99%

Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells

et al. 2020

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Excessive triglyceride accumulation in lipid-metabolizing tissues is associated with an increased risk of a variety of metabolic diseases. Kamishoyosan (KSS) is a Kampo composed of 10 constituent herbs, and contains moutan cortex (MC) and paeonol (PN) as the major ingredient of MC. Here, we demonstrate the molecular mechanism underlying the effect of KSS on the differentiation of mouse preadipocytes (3T3-L1 cells). KSS inhibited the accumulation of triglycerides in a dose-dependent manner in 3T3-L1 cells that were induced to differentiate into adipocytes. We also found that MC and PN were responsible for the anti-adipogenetic effect of KSS and significantly suppressed the expression of CCAAT/enhancer-binding proteins-δ (C/EBP-δ) mRNA 3 days after the induction of differentiation. Thus, PN may contribute to the anti-adipogenetic property of MC in 3T3-L1 cells. In addition, PN inhibited dexamethasone (Dex)-induced glucocorticoid receptor (GR) promoter activity. Taken together, these results suggest that PN suppresses C/EBP-δ expression by inhibiting Dex-induced GR promoter activity at the early stage of differentiation and, consequently, delays differentiation into mature adipocytes. Our results suggest that the habitual intake of Kampo-containing PN contributes to the prevention of the onset of metabolic diseases by decreasing the excessive accumulation of triglycerides in lipid-metabolizing tissues.

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“…Leptin is considered to be the most important factor in regulating the reproductive axis, and high leptin levels have been found in obese males [ 12 ]. Our previous study found that high leptin level was one of the mechanisms responsible for reducing the level of testosterone in obese males [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Di‐(2‐Ethylhexyl) Phthalate Increases Obesity‐Induced Damage to the Male Reproductive System in Mice

Zhao

Ren

Liu

et al. 2018

Oxidative Medicine and Cellular Longevity

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Objective This study evaluated the effects of di-(2-ethylhexyl) phthalate (DEHP) and obesity on male reproductive organ function in male mice and the potential mechanism of male secondary hypogonadism (SH) in such mice. Methods 140 mice were assigned to six groups for 12 weeks: normal, DEHP, DIO, DIO + DEHP low, DIO + DEHP middle, and DIO + DEHP high. The effects of DEHP and obesity upon the reproductive organs were determined by measuring sperm count and motility, relative testis and epididymis weight, hormone level, and pathological changes. Oxidative stress was evaluated by determining malondialdehyde, T-AOC, SOD, GSH, H2O2, CAT, and GSH-PX in testicular tissues. Nrf2 and Keap1 protein were measured by Western blotting. Results DEHP and obesity reduced sperm count and motility, relative testis and epididymis weight, and testosterone level but increased the levels of MDA, H2O2, leptin, and estradiol. Pathological injury was observed in the testicular Leydig cells. Moreover, the activity of CAT, SOD, and GSH-Px enzymes was inhibited. Nrf2 protein expression was reduced but that of Keap1 was increased. Conclusions DEHP and obesity jointly caused damage to male productive function. Oxidative stress in testicular tissue, and a high level of leptin, may provide some evidence to clarify the mechanisms of male SH with DEHP and obesity.

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Increased oral inflammation, leukocytes, and leptin, and lower adiponectin in overweight or obesity

Abstract: Overweight or obese Thai people were related to an increase in inflammatory dental and periodontal diseases with an altered health profile and plasma inflammatory mediators.

Cited by 26 publications

References 49 publications

Body fat rather than body mass index is associated with gingivitis – A southern Brazilian cross‐sectional study

Body fat rather than body mass index is associated with gingivitis – A southern Brazilian cross‐sectional study

Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells

Di‐(2‐Ethylhexyl) Phthalate Increases Obesity‐Induced Damage to the Male Reproductive System in Mice

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