2012
DOI: 10.1038/leu.2011.381
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Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation

Abstract: The involvement of osteocytes in multiple myeloma (MM)-induced osteoclast (OCL) formation and bone lesions is still unknown. Osteocytes regulate bone remodelling at least partially, as a result of their cell death triggering OCL recruitment. In this study, we found that the number of viable osteocytes was significantly smaller in MM patients than in healthy controls, and negatively correlated with the number of OCLs. Moreover, the MM patients with bone lesions had a significantly smaller number of viable osteo… Show more

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Cited by 120 publications
(123 citation statements)
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References 54 publications
(51 reference statements)
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“…In multiple myeloma, osteocyte apoptosis is markedly increased compared with that in normal patients and patients with monoclonal gammopathy of undetermined significance (MGUS) 120 . Osteocytes lose control of sclerostin secretion in this clinical scenario.…”
Section: Emerging Osteocyte and Sclerostin-targeted Therapeutic Optionsmentioning
confidence: 99%
“…In multiple myeloma, osteocyte apoptosis is markedly increased compared with that in normal patients and patients with monoclonal gammopathy of undetermined significance (MGUS) 120 . Osteocytes lose control of sclerostin secretion in this clinical scenario.…”
Section: Emerging Osteocyte and Sclerostin-targeted Therapeutic Optionsmentioning
confidence: 99%
“…It is now widely held dogma that osteocytes interact extensively with the cells of the bone marrow microenvironment, which directly implicates these cells in the regulation of the bone marrow, including during the arrival and progression of metastatic tumor cells. Indeed, in multiple myeloma patient bone biopsies, viable osteocyte number is significantly less than non-myeloma patients, which suggests that changes in osteocyte viability may precede the arrival of tumor cells [74]. How alterations in osteocyte viability and number, as well as other marrow-resident immune cells may affect breast cancer bone metastasis continues to be an obvious feature but remains a largely underexplored question.…”
Section: Hallmarks Of Breast Cancer Bone Metastasismentioning
confidence: 99%
“…Yet recent evidence from patients with multiple myeloma (MM), a blood cancer similarly associated with osteolytic lesions, indicates that osteocytes likely play a key role in cancer-related bone degradation. For example, osteocyte apoptosis, and subsequent osteoclastogenesis and osteolytic lesions, were all increased in MM patients [122]. Furthermore, circulating levels of sclerostin were elevated in MM patients and inversely correlated with bone mass, suggesting a direct connection between cancer-mediated differences in osteocyte signaling and osteolysis [123].…”
Section: Biology Of Bone Remodelingmentioning
confidence: 99%