Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype

Aydemir, Birsen; Onaran, İlhan; Kiziler, Ali Rıza; Alıcı, Bülent; Akyolcu, Mehmet Can

doi:10.1111/j.1745-7262.2007.00237.x

Cited by 79 publications

(72 citation statements)

References 33 publications

(38 reference statements)

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“…The characteristics of selected studies are summarized in Table 1. A total of 12 eligible studies met the inclusion criteria, including 11 studies for GSTM1 [14,15,[25][26][27][28][29][30][31][32][33] and 9 ones for GSTT1 [17,26,27,[29][30][31][32][33]. All the included studies were case-control studies.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

“…Published studies are available on the association of genotype in GSTM1, GSTT1 genes and idiopathic male infertility. GSTM1 polymorphism might be an important source of variation in susceptibility of spermatozoa to oxidative damage in patients with idiopathic infertility [14]. GSTT1 has functional polymorphisms that result in the virtual absence of enzyme activity [13].…”

Section: Introductionmentioning

confidence: 99%

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Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis

Song

Zhao

Cai

et al. 2012

J Assist Reprod Genet

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Background Genes of different pathways regulate spermatogenesis, and the complexity of the spermatogenic process indicates that polymorphisms or mutations in these genes could cause male infertility. Published data on the association between the GSTM1 and GSTT1 polymorphism and male infertility risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Methods A total of 11 studies regarding GSTM1 and 9 studies regarding GSTT1 between 1999 and 2012 were identified through researching MEDLINE, EMBASE and the Chinese Biomedical Database. It was performed to obtain summary estimated odd ratios and 95 % confidence intervals of GSTM1 and GSTT1 for male infertility, with attention to study quality and publication bias. Results Overall, a significant association was seen between GSTM1 (OR01.20, 95 % CI 01.02-1.40, P heterogeneity 0 0.000, P00.027) genotypes and male infertility. Significant associations were also observed in subgroups of Caucasian populations (OR01.65, 95 %CI01.16-2.34, P heterogeneity 0 0.006, P00.005), but were not observed in Asian populations (OR01.09, 95 % CI00.72-1.65, P heterogeneity 00.054, P00.697) when stratified by ethnicity. While there was no significant association was seen between GSTT1 (OR0 1.00, 95 % CI00.74-1.35, P heterogeneity 00.000, P00.980) null genotypes and male infertility. Simultaneously, significant associations were not observed in subgroups of Caucasian populations (OR 00.94, 95 %CI 00.44-2.00, P heterogeneity 00.000, P 00.867) and Asian populations (OR00.93, 95 % CI00.46-1.87, P heterogeneity 00.002, P0 0.838) when stratified by ethnicity. Conclusion Our results suggest the GSTM1 null genotype contributes to male infertility susceptibility, while GSTT1 gene polymorphisms are not associated with male infertility in our study.

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Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis

Song

Zhao

Cai

et al. 2012

J Assist Reprod Genet

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“…21 Inconsistent studies are available on the association of polymorphism in GSTM1, GSTT1 and GSTP1 genes and idiopathic male infertility. Aydemir et al 22 reported that in patients with idiopathic infertility, GSTM1 polymorphism might be an important source of variation in susceptibility of spermatozoa to oxidative damage. In a study conducted in Russian men, Polonikov et al 23 reported that the nondeletion genotype of the GSTT1 gene is strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia.…”

Section: Introductionmentioning

confidence: 99%

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

2010

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The effects of the GST genes (GSTM1, GSTT1 and GSTP1) on male factor infertility have not been well elucidated. A casecontrol study was performed to investigate the association between functionally important polymorphisms in GST genes and idiopathic male infertility. The study group consisted of 166 men suffering from idiopathic oligoasthenoteratozoospermia (OAT) and an equal number of age-matched healthy fertile male controls. Genomic DNA extracted from the peripheral blood, was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Multivariate regression analysis showed an increase in risk to infertility in the patients with null genotype of GSTM1 (OR: 2.18; 95% CI: 1.64-3.32; P¼0.001) or GSTT1 (OR: 1.88; 95% CI:1.12-2.52; P¼0.04). Our data further showed that combination of deletion genotypes of GST (GSTM1 and GSTT1) pose an even higher risk of infertility. In addition, GSTP1 wild-type genotype in combination with GSTM1 null or GSTT1 null genotype increased probability for infertility (OR: 2.47, 95% CI: 1.46-4.17: and OR: 2.69, 95% CI: 1.39-5.32, respectively). Similarly a much higher risk for infertility was noted in the patients carrying a genotype combination of GSTM1 null, GSTT1 null and GSTP1 (Ile/Ile) (OR: 4.45; 95% CI: 1.59-12.24; P¼0.002). The variant genotypes of GSTP1 (Ile/Val and Val/Val) resulted in a significant decreased risk to infertility in the cases (OR: 0.44; 95% CI: 0.29-0.78, P¼0.004). These results support the hypothesis of increased risk of GSTM1 or GSTT1null genotypes for developing infertility, but the nondeletion GSTM1 and GSTT1genotypes emerged as protective factors.

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“…Approximately 30% of men seeking treatment for their infertility present no demonstrable etiology and their condition remains idiopathic (Pasqualotto and Pasqualotto, 2006). It is a heterogeneous disorder, with several genetic and environmental factors contributing to impaired spermatogenesis (Aydemir et al, 2007). Studies revealed a significant decline in human semen quality and quantity over the past decades, and the increasing occurrence of disorders of the male reproductive tract is yet unknown.…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

Finotti

Silva²,

Bordin³

et al. 2009

Genet. Mol. Res.

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ABSTRACT. Male infertility is a heterogeneous disorder, with various genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxifying enzymes of phase II drug metabolism can modify their expression or function, affecting the biotransformation of toxic compounds to which the male reproductive system is exposed. GSTM1 and GSTT1 encode enzymes that are essential in the process of detoxification of endogenous and exogenous xenobiotics, facilitating their excretion. We examined GSTM1 and GSTT1 polymorphism in 233 men with idiopathic infertility seen at the Human Reproduction Service of the Federal University of Goiás from [2004][2005][2006]. Genotype GSTM1/T1 (null) was found in 30/105 normal individuals and in 64/128 abnormal individuals, indicating a significant association with idiopathic male infertility. The sperm alteration associated with greater GSTM1/T1 (null) frequency was decreased sperm count (oligozoospermy), which was more frequent in patients with GSTM1 (78.9%) as well as in those who had GSTT1 (73.7%), although the difference was not significant. Individuals polymorphic for genes GSTM1 and GSTT1 are susceptible to reduction in sperm quality and infertility, possibly because oligozoo-

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Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype

Cited by 79 publications

References 33 publications

Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis

Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

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