Increased oxidative stress in children exposed to passive smoking

Kösecik, Mustafa; Erel, Özcan; Sevinç, Eylem; Selek, Sahabettın

doi:10.1016/j.ijcard.2004.05.069

Cited by 255 publications

(156 citation statements)

References 24 publications

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“…MDA was determined using the thiobarbituric acid reaction [12]. TP was determined by the FOX2 method as previously described by Kosecik with minor modifications [19]. Total antioxidant status (TAS) was determined by modifying a novel automated measurement method as previously described [19].…”

Section: Oxidative Status Determinationsmentioning

confidence: 99%

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Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status

Nagila

Permpongpaiboon

Tantrarongroj

et al. 2009

Pharmacological Reports

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Abstract:It has been proposed that paraoxonase1 (PON1), a high density lipoprotein (HDL)-associated esterase/lactonase, has antiatherosclerotic properties. The activity of PON1 is influenced by PON1 polymorphisms. However, the influence of PON1 polymorphisms on PON1 activity and oxidative stress in response to lipid-lowering drugs remains poorly understood. The objective of the present study was to investigate the effects of atorvastatin on PON1 activity and oxidative status. The influence of PON1 polymorphisms on PON1 activity and oxidative status in response to atorvastatin treatment was also evaluated. In total, 22 hypercholesterolemic patients were treated with atorvastatin at a dose of 10 mg/day for 3 months. Lipid profile, lipid oxidation markers (malondialdehyde (MDA), conjugated diene (CD), total peroxides (TP)), total antioxidant substance (TAS), oxidative stress index (OSI), and paraoxonase1 activity were determined before and after treatment. L55M, Q192R, and T(-107)C PON1 polymorphisms were also determined. Atorvastatin treatment significantly reduced the levels of total cholesterol (24.5%), low density lipoprotein (LDL) cholesterol (25.4%), triglycerides (24.4%), CD (4.4%), MDA (15.2%), TP (13.0%) and OSI (24.0%), and significantly increased the levels of TAS (27.3%), and PON1 activity (14.0%). Interestingly, the increase in PON1 activity and the reduction in oxidative stress in response to atorvastatin were influenced only by the PON1 T-107C polymorphism. Atorvastatin treatment improved the lipid profile, lipid oxidation, and oxidative/antioxidative status markers including the activity of PON1 towards paraoxon. These beneficial effects may be attributed to the antioxidant properties of statins and the increase in PON1 activity. The increase in PON1 activity was enhanced by the PON1 T-107C polymorphism.

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Section: Oxidative Status Determinationsmentioning

confidence: 99%

“…Total antioxidant status (TAS) was determined by modifying a novel automated measurement method as previously described [19]. The oxidative stress index (OSI) was calculated using the following formula: OSI = (total peroxides, mM)/(TAS, mM trolox equivalent/l) × 100] [19].…”

Section: Oxidative Status Determinationsmentioning

confidence: 99%

Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status

Nagila

Permpongpaiboon

Tantrarongroj

et al. 2009

Pharmacological Reports

View full text Add to dashboard Cite

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“…TAC on the other hand reflects the total antioxidant status of serum; a measurement method has recently been developed (Erel 2004b). In this method, TAC of sera which acts especially against potent free radical reactions which cause strong oxidative damage of biomolecules such as lipids, proteins and DNA, is measured (Kosecik et al 2005).…”

mentioning

confidence: 99%

Total oxidant and antioxidant capacities, nitric oxide and malondialdehyde levels in cats seropositive for the feline coronavirus

Kayar¹,

Dokuzeylül²,

Kandemır³

et al. 2015

Vet. Med. - Czech

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Feline coronavirus (FCoV) is a highly contagious virus that is ubiquitous in multicat environments and may induce oxidative stress. This virus commonly causes an asymptomatic infection, which can persist in certain individuals. Sporadically and unpredictably, FCoV infection leads to feline infectious peritonitis (FIP), a highly fatal systemic immune-mediated disease. There are no data in the veterinary literature relating to oxidative stress in FCoV. Antioxidant capacity (TAC) can be attributed to single components in the defence systems against free radicals. The measurement of the total oxidant status (TOS) accurately reflects the oxidative status of blood plasma or serum. Nitric oxide (NO) acts as a free radical and contributes to host defences against oxidation. Malondialdehyde (MDA) is a reliable and commonly used marker of overall lipid peroxidation levels and the presence of oxidative stress. This study aimed to determine levels of oxidative stress markers, serum TAC, total oxidant capacity (TOC), NO and serum MDA in 24 cats seropositive for FCoVs and 15 cats seronegative for FCoVs. Significantly higher serum TOC, NO and MDA levels were found in seropositive animals (P < 0.001, P < 0.05 and P < 0.001, respectively) than in seronegative animals. In contrast, serum TAC levels were found to be significantly lower in seropositive cats compared with seronegative cats (P < 0.001). The results of the present study suggest that FCoV seropositivity is associated with oxidative stress and decreased antioxidant status.

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“…27 Kosecik at al demonstrated that increased ROS production was associated with increased cigarette smoke exposure in children. 28 In another study it was reported that exposure to cigarette smoke causes changes in the oxidative enzyme levels in rat testis and these harmfull effects can be reversed by caffeic acid phenethyl ester. 29 The other mechanism of negative effect of ETS may also be an inflammatory effect of polycyclic aromatic hydrocarbons (PAH) which is one of the compounds of cigarette smoke.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Environmental Tobacco Smoke on the Testicular Functions of 7-10 Years Old Children

Karaman¹,

Taş²,

Temel³

et al. 2012

JIUMF

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Purpose: To investigate the effect of environmental tobacco smoke (ETS) on the testicle functions of 7-10 years old children. Materials and Methods: The study included healthy male children aging between 7-10 years. Based on the questionnaire data, 50 passive smoking (PS) cases and 50 passive smoking free controls were determined. Serum levels of cotinine, and biochemical parameters of the testicle functions; testosterone, inhibin B, anti-mullerian hormone (AMH) along with FSH and LH levels were evaluated. Results: Serum cotinine levels in PS group were found higher than the controls (p<0,05). Testosterone, inhibin-B, FSH, and LH levels of the control group was found higher than the PS group. The AMH levels were found lower in the controls in comparison with the PS group (p<0,05). Conclusions: Our results showed that ETS leads to testicular dysfuntions. We think that preventing exposure to cigarette smoke in childhood is very important for their reproductive system.

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Increased oxidative stress in children exposed to passive smoking

Cited by 255 publications

References 24 publications

Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status

Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status

Total oxidant and antioxidant capacities, nitric oxide and malondialdehyde levels in cats seropositive for the feline coronavirus

The Effect of Environmental Tobacco Smoke on the Testicular Functions of 7-10 Years Old Children

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