Increased percentage of activated Ia+ T lymphocytes in peripheral blood of neonates following exchange blood transfusion

Effectiveness of WBC reduction in neonates: what is the evidence of benefit?

“…Four studies evaluated the effectiveness of WBC reduction in acquiring CMV infection 21‐24 . Three studied the effect on developing HLA antibodies, 25‐27 and two studied immunomodulatory effects 28,29 . No studies were identified with a stated primary objective of examining the effect of WBC reduction on either CMV disease, nosocomial infection, mortality, or duration of stay.…”

“…In the nonrandomized controlled study, 29 a cohort of three newborns who received a total blood exchange with WBC‐reduced blood experienced only a very slight enhancement (16%) of Ia+ T lymphocytes 5 days after the exchange transfusion whereas there was no change in the T‐lymphocyte subsets in nine control newborns who did not receive transfusion. Baseline data at the group or individual level were not provided to calculate a measure of effect.…”

“…Of 476 references identified by the systematic literature search, nine studies meeting the inclusion criteria were identified, [21][22][23][24][25][26][27][28][29] including five RCTs, three nonrandomized controlled studies, and one before and after study (Tables 1 and 2). An additional duplicate publication 30 and an evaluation of cardiac perioperative variables 31 were identified and not included.…”

Immune response to blood transfusion invery‐low‐birthweight infants

“…Romano et al 25 reported an increase in Ia‐like (DR) antigens in the peripheral blood T cells of 20 infants 2 days after transfusion. However, the increase in DR+ cells in the current study can only be ascribed to B cells, as we measured the number of CD3–/DR+ cells, and there was no increase in CD3+/DR+ cells.…”

“…A single report assesses the immunologic response to the transfusion of presumably unmodified blood in infants. Romano et al 25 showed that neonatal lymphocytes expressed increased levels of HLA‐DR 2 days after exchange transfusion with unmodified allogeneic blood and 5 days after receiving WBC‐reduced blood, but no changes were observed in infants who received irradiated blood. Upregulation of CD25 (IL‐2 receptor) was also observed after the transfusion of unmodified blood.…”