Increased percentage of mast cells within sinonasal mucosa of chronic rhinosinusitis with nasal polyp patients independent of atopy

Shaw, Joanne; Ashoori, Faramarz; Fakhri, Samer; Citardi, Martin J.; Luong, Amber U.

doi:10.1002/alr.21021

Cited by 36 publications

(29 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found fibroblasts to be independent of atopic status in patients with CRSwNP, which is similar to that of other inflammatory cells. 39 This finding corroborates recent evidence showing that atopy does not correlate with severity of disease; 40 however, it contradicts some studies emphasizing the importance of atopy in assessing symptom severity. 41 Increased fibroblasts in patients with CRSwNP and AFRS correlated with worse subjective disease severity as measured by SNOT-22.…”

Section: Discussionsupporting

confidence: 75%

Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity

Carroll

O’Connell

Schlosser

et al. 2015

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 75%

Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity

Carroll

O’Connell

Schlosser

et al. 2015

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

“…Local release of factors from these effector cells is widely believed to be the proximate cause of the tissue damage and remodeling changes associated with both forms of CRS. In regard to pathogenesis, most interest has centered on eosinophils 545 and mast cells, 546,547 although elevated levels of neutrophils and macrophages are also present and phagocytic activity may be impaired in CRS. 548 ECs express enzymes involved in the generation of reactive oxygen species and reactive nitrogen species that are important in multiple epithelial processes, including mucin production, epithelial repair, innate immunity, and response to environmental toxins.…”

Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

558

888

View full text Add to dashboard Cite

Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

show abstract

“…We previously demonstrated increased frequency of both CD4 1 T cells and mast cells in inflamed sinonasal mucosa from patients with CRSwNP compared with patients with CRSsNP independent of atopy (28), and these cells likely contribute to the elevated expression of ST2 observed in inflamed ethmoid sinus mucosa from patients with CRSwNP.…”

Section: Mucosa From Patients With Crswnp Compared With Patients Withmentioning

confidence: 90%

IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Shaw

Fakhri²,

Citardi³

et al. 2013

Am J Respir Crit Care Med

Self Cite

256

221

View full text Add to dashboard Cite

Rationale: Chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) are associated with Th1 and Th2 cytokine polarization, respectively; however, the pathophysiology of CRS remains unclear. The importance of innate lymphoid cells in Th2-mediated inflammatory disease has not been clearly defined. Objectives: The objective of this study was to investigate the role of the epithelial cell-derived cytokine IL-33 and IL-33-responsive innate lymphoid cells in the pathophysiology of CRS. Methods: Relative gene expression was evaluated using quantitative real-time polymerase chain reaction. Innate lymphoid cells in inflamed ethmoid sinus mucosa from patients with CRSsNP and CRSwNP were characterized using flow cytometry. Cytokine production from lymphoid cells isolated from inflamed mucosa of patients with CRS was examined using ELISA and intracellular cytokine staining. Chronic rhinosinusitis (CRS) is a chronic inflammatory process of the nasal and paranasal sinus mucosa affecting more than 30 million people annually, resulting in significant direct healthcare costs (1). CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) are associated with Th1 and Th2 cytokine polarization, respectively (2, 3), although the cellular and molecular mechanisms driving the Th2-mediated inflammation in CRSwNP are not clearly understood (4, 5). Due largely to a lack of understanding of the pathophysiology of CRS, current treatment options, including high-dose glucocorticosteroids and surgeries, remain noncurative, generic, and largely unchanged over the past decade.IL-33, a member of the IL-1 family of cytokines, is expressed by epithelial cells, endothelial cells, fibroblasts, smooth muscle cells, macrophages, and dendritic cells (6-8). The IL-33 receptor, a heterodimeric complex composed of ST2 and IL-1 receptor accessory protein (IL1RAP), is expressed on numerous immune cells, including Th2 cells, mast cells, basophils, eosinophils, and macrophages (7-9). IL-33 is a chemoattractant for Th2 cells (10) and promotes Th2 polarization of naive CD4 1 T cells, enhancing production of IL-5 and IL-13 independent of IL-4 (11). IL-33 can also induce proinflammatory cytokine and chemokine production by mast cells and enhance degranulation (12), stimulate basophils and eosinophils (13), and enhance IL-13-driven polarization of alternatively activated macrophages (14). More recently, an important role for IL-33 in regulating the development and function of type 2 innate lymphoid cells (ILC) was described (15, 16). The epithelial cell-derived cytokine IL-33 is known to play a key role in the development and regulation of a Th2 immune response, mediated in part by an IL-33-responsive innate lymphoid cell population. However, there is little direct evidence of an important role for these cells in Th2-mediated inflammatory disease in humans. What This Study Adds to the FieldHere we show that the percentage of innate lymphoid cells is significantly elevated in diseased mucosa in chronic rhinosinusitis w...

show abstract

Increased percentage of mast cells within sinonasal mucosa of chronic rhinosinusitis with nasal polyp patients independent of atopy

Abstract: Elevated percentages of MCs are found in the sinonasal mucosa of CRSwNP patients, regardless of atopic status. Secreted by MCs, elevated prostaglandin D(2) may play a role in the recruitment of CRTH2(+) cells to the inflamed mucosa of CRSwNP patients.

Cited by 36 publications

References 23 publications

Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity

Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Contact Info

Product

Resources

About