Increased permeability of human amnion to calcium ions in chorioamnionitis is related to histamine H1-receptor overexpression within amniotic epithelial cells

Szukiewicz, Dariusz; Klimkiewicz, Jakub; Pyźlak, Michał; Stelmachów, J; Maślińska, D.

doi:10.1007/s00011-009-2013-3

Cited by 2 publications

(1 citation statement)

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“…If so, what then is the plausible mechanism for the association between an elevated CVF VDBP level and positive AF cultures in PTL? The most likely mechanism of this association may be related to the potential acceleration of the transudative process of solutes crossing the inflamed or infected chorioamniotic membrane from the amniotic cavity into the CVF [ 24 ], which occurs in intra-amniotic infection. Indeed, the previous reports by Ma et al [ 25 ] and Guha et al [ 26 ] support this speculation.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D-binding protein in cervicovaginal fluid as a non-invasive predictor of intra-amniotic infection and impending preterm delivery in women with preterm labor or preterm premature rupture of membranes

et al. 2018

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ObjectiveTo determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of intra-amniotic infection and imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL) or preterm premature rupture of membranes (PPROM).MethodThis was a single-center retrospective cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels immediately after amniocentesis in consecutive women with PTL (n = 148) or PPROM (n = 103) between 23.0 and 34.0 weeks of gestation. VDBP levels in CVF were determined by enzyme-linked immunosorbent assay kits. The primary outcome measures were intra-amniotic infection [defined as positive amniotic fluid (AF) culture] and SPTD within 48 hours after sampling.ResultsIn the multivariable analysis, elevated VDBP levels in CVF samples of PTL women were significantly associated with intra-amniotic infection and imminent preterm delivery, even after adjusting for potential confounders (e.g., gestational age at sampling, parity, and serum CRP). However, these relationships were not found in women with PPROM. In women with PTL, the areas under receiver operating characteristic curves of CVF VDBP level for predicting intra-amniotic infection and imminent preterm delivery were 0.66 and 0.71, with cut-off values of 1.76 μg/mL (sensitivity of 64.3% and specificity of 78.4%) and 1.37 μg/mL (sensitivity of 65.4% and specificity of 72.6%), respectively. The CVF VDBP levels were significantly higher in women with PPROM than in those with PTL.ConclusionsVDBP in the CVF independently predicts intra-amniotic infection and imminent preterm delivery in women with PTL, whereas in women with PPROM, an elevated VDBP level in CVF is not associated with increased risks of these two outcome variables.

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Section: Discussionmentioning

confidence: 99%