Increased Phospholipid Flux Bypasses Overlapping Essential Requirements for the Yeast Sac1p Phosphoinositide Phosphatase and ER-PM Membrane Contact Sites

Nenadic, Aleksa; Zaman, Mohammad F.; Johansen, Jesper; Volpiana, Matthew W.; Beh, Christopher T.

doi:10.1016/j.jbc.2023.105092

Journal of Biological Chemistry

2023

DOI: 10.1016/j.jbc.2023.105092

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Increased Phospholipid Flux Bypasses Overlapping Essential Requirements for the Yeast Sac1p Phosphoinositide Phosphatase and ER-PM Membrane Contact Sites

Aleksa Nenadic,

Mohammad F. Zaman,

Jesper Johansen

et al.

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2024

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Regulation of yeast polarized exocytosis by phosphoinositide lipids

Volpiana,

Nenadic,

Beh

2024

Cell. Mol. Life Sci.

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Phosphoinositides help steer membrane trafficking routes within eukaryotic cells. In polarized exocytosis, which targets vesicular cargo to sites of polarized growth at the plasma membrane (PM), the two phosphoinositides phosphatidylinositol 4-phosphate (PI4P) and its derivative phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) pave the pathway for vesicle transport from the Golgi to the PM. PI4P is a critical regulator of mechanisms that shape late Golgi membranes for vesicle biogenesis and release. Although enriched in vesicle membranes, PI4P is inexplicably removed from post-Golgi vesicles during their transit to the PM, which drives subsequent steps in exocytosis. At the PM, PI(4,5)P2 recruits effectors that establish polarized membrane sites for targeting the vesicular delivery of secretory cargo. The budding yeast Saccharomyces cerevisiae provides an elegant model to unravel the complexities of phosphoinositide regulation during polarized exocytosis. Here, we review how PI4P and PI(4,5)P2 promote yeast vesicle biogenesis, exocyst complex assembly and vesicle docking at polarized cortical sites, and suggest how these steps might impact related mechanisms of human disease.

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Regulation of yeast polarized exocytosis by phosphoinositide lipids

Volpiana,

Nenadic,

Beh

2024

Cell. Mol. Life Sci.

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Increased Phospholipid Flux Bypasses Overlapping Essential Requirements for the Yeast Sac1p Phosphoinositide Phosphatase and ER-PM Membrane Contact Sites

Cited by 1 publication

References 119 publications

Regulation of yeast polarized exocytosis by phosphoinositide lipids

Regulation of yeast polarized exocytosis by phosphoinositide lipids

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