Increased plasma and salivary cortisol levels in patients with oral cancer and their association with clinical stage

Bernabé, Daniel Galera; Tamae, Adriano Caires; Miyahara, Glauco Issamu; Sundefeld, Maria Lúcia Marçal Mazza; Oliveira, Sandra Cristina de; Biasoli, Éder Ricardo

doi:10.1136/jclinpath-2012-200695

Cited by 43 publications

(50 citation statements)

References 42 publications

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“…In SCC group stress and depression level was higher than normal when assessed by DAS Scale, which correlated with Hann D et al 29 in (2002) who observed higher depression score in cancer patients of older age group compared to females and younger age patients. Also the salivary cortisol level was higher than normal range which was consistant with Bernabe DG et al 30 who observed higher plasma and salivary cortisol level in oral squamous cell carcinoma patients compared to oropharyngeal carcinoma, leukoplakia, smokers and healthy patients.…”

Section: Discussion:-supporting

confidence: 73%

Stress Evaluation Using Das Scale and Salivary Cortisol in Patients With Oral Lichen Planus, Oral Submucous Fibrosis, Leukoplakia and Squamous Cell Carcinoma.

S¹,

M²,

P³

et al. 2016

IJAR

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Section: Discussion:-supporting

confidence: 73%

Stress Evaluation Using Das Scale and Salivary Cortisol in Patients With Oral Lichen Planus, Oral Submucous Fibrosis, Leukoplakia and Squamous Cell Carcinoma.

S¹,

M²,

P³

et al. 2016

IJAR

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“…Cortisol, a steroid hormone secreted by the adrenal cortex, is used to assess hypothalamic-pituitary-adrenal axis function and is a reliable measure of physiological stress. [18] Cortisol affects multiple physiological processes, including metabolic and immune responses (e.g., suppressing T lymphocyte functions and natural killer cell cytotoxicity). Women living with breast cancer have higher cortisol levels as compared to healthy women, and higher cortisol levels are associated with greater disease severity in women with breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trial in advance stage breast cancer patients for the effectiveness on stress marker and pain through Sudarshan Kriya and Pranayam

Kumar¹,

Bhatnagar²,

Velpandian³

et al. 2013

Indian J Palliat Care

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Objective:The objective of this study is to examine the effect of a cognitive, behavioral stress management module of Sudarshan Kriya (SK) and P on levels of serum cortisol and pain among the women suffering from advanced stage breast cancer.Materials and Methods:Participants (n = 147) were screened and randomized to receive standard care (n = 69) versus standard along with SK and Pranayam (P) intervention (n = 78) imparted in one 18 hrs workshop spread during 3 days. Participants were expected to practice it at home 20 min daily as adjuvant to standard pharmacological treatment for pain.Results:There was a significant difference in blood cortisol levels after 3 months of practice of SK and P. Mean blood levels in the intervention arm were 341.2 ng/ml against 549.2 ng/ml in the control arm (P ≤ 0.002). Pain perception in comparison to control arm reduced by 3 points in SK and P arm on 0-10 verbal scale of pain.Conclusion:SK and P is an effective intervention in reducing stress and pain among advance stage patients of breast cancer.

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“…Other systemic effects of tumor-associated inflammation have been noted, especially alteration of the hypothalamic-pituitary-adrenal (HPA) axis. Altered cortisol patterns have been identified in ovarian cancer patients (Weinrib et al, 2010), endometrial cancer patients (Sannes et al, 2013), and oral cancer patients (Bernabé et al, 2012) prior to treatment. In ovarian cancer patients, these patterns are significantly associated with IL-6 concentrations in the ascites fluid (Schrepf et al, 2015) and in plasma (Lutgendorf et al, 2008).…”

Section: Cancer Patients Prior To Treatmentmentioning

confidence: 99%

Pre-treatment effects of peripheral tumors on brain and behavior: Neuroinflammatory mechanisms in humans and rodents

Schrepf¹,

Lutgendorf²,

Pyter³

2015

Brain, Behavior, and Immunity

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Cancer patients suffer high levels of affective and cognitive disturbances, which have been attributed to diagnosis-related distress, impairment of quality of life, and side effects of primary treatment. An inflammatory microenvironment is also a feature of the vast majority of solid tumors. However, the ability of tumor-associated biological processes to affect the central nervous system (CNS) has only recently been explored in the context of symptoms of depression and cognitive disturbances. In this review, we summarize the burgeoning evidence from rodent cancer models that solid tumors alter neurobiological pathways and subsequent behavioral processes with relevance to affective and cognitive disturbances reported in human cancer populations. We consider, in parallel, the evidence from human clinical cancer research demonstrating that affective and cognitive disturbances are common in some malignancies prior to diagnosis and treatment. We further consider the underlying neurobiological pathways, including altered neuroinflammation, tryptophan metabolism, prostaglandin synthesis and associated neuroanatomical changes, that are most strongly implicated in the rodent literature and supported by analogous evidence from human cancer populations. We focus on the implications of these findings for behavioral researchers and clinicians, with particular emphasis on methodological issues and areas of future research.

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Increased plasma and salivary cortisol levels in patients with oral cancer and their association with clinical stage

Abstract: These results indicate a dysregulation of cortisol secretion in patients with oral cancer and suggest that this hormone can be a biomarker associated with the disease's clinical status.

Cited by 43 publications

References 42 publications

Stress Evaluation Using Das Scale and Salivary Cortisol in Patients With Oral Lichen Planus, Oral Submucous Fibrosis, Leukoplakia and Squamous Cell Carcinoma.

Stress Evaluation Using Das Scale and Salivary Cortisol in Patients With Oral Lichen Planus, Oral Submucous Fibrosis, Leukoplakia and Squamous Cell Carcinoma.

Randomized controlled trial in advance stage breast cancer patients for the effectiveness on stress marker and pain through Sudarshan Kriya and Pranayam

Pre-treatment effects of peripheral tumors on brain and behavior: Neuroinflammatory mechanisms in humans and rodents

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