Increased plasma catecholamine concentrations and vas deferens norepinephrine biosynthesis in men with elevated blood pressure.

DeQuattro, Vincent; Miura, Yukio; Lurvey, Arthur; Cosgrove, Malcolm D.; Méndez, R.

doi:10.1161/01.res.36.1.118

Cited by 52 publications

(8 citation statements)

References 27 publications

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“…If plasma NE levels increase significantly with age only in normotensive subjects, 9 then ultimately NE levels could be expected to be higher in normotensive subjects in extreme old age. Contrary to findings in young and middle-aged hypertensive persons, in whom plasma catecholamine levels are positively related to arterial blood pressure, 57 an inverse relation between plasma NE level and both systolic and diastolic blood pressure has been recently noted in older hypertensive persons. 58 This inverse correlation was confirmed in the present study.…”

Section: Discussioncontrasting

confidence: 79%

Dissociation of 24-hour catecholamine levels from blood pressure in older men.

Stern¹,

Beahm²,

McGinty³

et al. 1985

Hypertension

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SUMMARY Increased plasma norepinephrine levels have been observed in some persons with early essential hypertension. Although both plasma norepinephrine level and mean arterial blood pressure rise with age, little is known about the state of catecholamine secretion in elderly patients with essential hypertension. We studied the 24-hour cycle levels of plasma norepinephrine, epinephrine, and dopamine in 12 elderly hypertensive subjects and 13 age-matched normotensive controls (mean ages, 63.8 ± 1.2 yr and 64.8 ± 1.8 yr [SEM] respectively). Blood samples were obtained at bihourly intervals from 0900 to 2100 hours and every 30 minutes from 2100 to 0900 hours, during which time sleep and breathing were continuously monitored. A circadian rhythm was displayed in both groups by plasma epinephrine levels (mesor, 49 ± 2 pg/ml and 38 ± 1 pg/ml; amplitude, 15 ± 2 pg/ml and 11 ± 1 pg/ml; acrophase, 12.20 ± 0.40 hr and 14.41 ± 0.34 hr in the normotensive and hypertensive groups respectively) but not by plasma norepinephrine or dopamine levels. During the 24-hour cycle plasma epinephrine, but not norepinephrine or dopamine, levels were positively related to mean arterial blood pressure (r = 0.60 for the normotensive subjects, r = 0.57 for the hypertensive subjects, p < 0.01 for both). Mean 24-hour plasma norepinephrine (377 ± 9 pg/ml vs 455 ± 9 pg/ml; p < 0.001), epinephrine (34 ± 2 pg/ml vs 45 ± 2 pg/ml; p < 0.01), and dopamine (40 ± 2 pg/ml vs 62 ± 3 pg/ml; p < 0.01) levels were lower in the hypertensive group, although groups did not differ in parameters known to affect catecholamine secretion such as body weight, sodium intake, sleep efficiency, or sleeprelated breathing disorders. Mean 24-hour plasma norepinephrine level was inversely related to the 24-hour mean arterial blood pressure (r = -0.48, p < 0.05). High norepinephrine levels in the elderly may reflect decreased baroreceptor sensitivity as well as compensatory response to decreased /3-adrenergic receptor sensitivity. It is unclear why elderly hypertensive persons, unlike younger hypertensive persons, have lower plasma catecholamine levels than do elderly normotensive persons. Whereas increased sympathetic outflow has been implicated in the induction of early "neurogenic" essential hypertension, 4 the age-dependent increase in NE is observed in normotensive subjects. Whether the ob- served increment in circulating NE is related to the age-associated rise in blood pressure or to the increased incidence of hypertension in aging humans is unclear. 5 The increase in NE with advancing age instead could reflect a compensatory mechanism to a declining peripheral response to adrenergic stimuli 6 -7 or an age-related decrease in clearance of NE. 8 Moreover, a recent study based on single NE samples obtained from a large number of subjects with a wide age range concluded that NE increases with age in normotensive subjects but not in subjects with essential hypertension. 9 However, there is relatively little direct information about the state of plasma catecholamines in...

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Section: Discussioncontrasting

confidence: 79%

Dissociation of 24-hour catecholamine levels from blood pressure in older men.

Stern¹,

Beahm²,

McGinty³

et al. 1985

Hypertension

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“…Elevated TH activity in vas deferens of SHR after establishment of hypertension is in agreement with the results in studies on humans by DeQuattro et al (13) who found in creased TH activity in the vas deferens with a concomitant elevated systolic blood pressure.…”

Section: Discussionsupporting

confidence: 92%

Norepinephrine-Synthesizing Enzymes in Brain, Adrenals and Peripheral Sympathetic Nerves of Spontaneously Hypertensive Rats

Nagatsu

Kato

Numata

et al. 1977

Japanese Journal of Pharmacology

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Abstract-Dopamine-,;7-hydroxylase (DBH) activity in serum, DBH and tyrosine hydroxylase (TH) activities in mesenteric vessels, and DBH and TH activities in locus coeruleus and hypothalamus of brain did not differ significantly between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKR) at 16 weeks of age when hypertension of SHR was fixed. In contrast, DBH and TH activities in vas deferens and adrenal glands were significantly higher in SHR than in WKR. These changes in SHR at 16 weeks of age after establishment of hypertension are directly opposite those reported previously in SHR at 3 weeks of age before the onset of hyper tension.We have previously reported (1, 2) that dopamine-;3-hydroxylase (DBH) activity in young spontaneously hypertensive rats (SI-I R) (3) was increased in serum and mesenteric vessels and was decreased in the locus coeruleus area of the brain. These results suggest that the sympathetic nerve activity may be increased in blood vessels due to a low norad rencrgic activity in the brainstem of young SHR before the onset of hypertension. During the development and maintenance of hypertension in SHR from 6 to 53 weeks of age, serum DBH activity in SHR was found to be similar to that in control normotensive Wistar-Kyoto rats (WKR) (1), suggesting that the peripheral sympathetic nerve activity may be decreased to the level of normotensive WKR by a compensatory mechanism.We investigated DBH activity in serum, and DBH and tyrosine hydroxylase (TH) activities in mesenteric vessels, vas deferens, adrenals and ca tech olaminergic regions of brain in SHR and WKR at 16 weeks of age when the hypertension is fixed, in order to compare the activity of the peripheral sympathetic nerves, adrenal glands and catechola ininergic neurons of the brain.

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“…With Bob Mendez 13 we found that plasma CA and tissue levels of NA were both raised and CA biosynthesis activity was increased. The rate limiting step, tyrosine hydroxylase activity, was also increased.…”

Section: Human Vas Deferensmentioning

confidence: 93%

The sympathetic nervous system: the muse of primary hypertension

DeQuattro

Feng

2002

J Hum Hypertens

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the sympathetic neurotransmitter noradrenaline (NA) and postulated that excessive neural tone was a cause of primary hypertension (PH). Thirty years ago, we found raised NA levels in 30-40% of young patients with PH. Laragh found plasma renin activity (PRA) a risk marker for coronary artery disease. With Esler, Miura, and Campese, a close association was found of plasma NA with PRA. We found raised tyrosine hydroxylase activity (AC) in the hearts of a rabbit model of sinoaortic denervated hypertension and in PH with raised plasma NA. Esler utilised titrated NA infusion and described increased spillover of NA from heart, kidney and subcortical areas of brain of patients with PH. With Eide we found raised cerebrospinal fluid (CSF) NA in PH (not secondary hypertension) and with Kolloch and Miura, we found raised plasma/CSF NA in conjunction with reduced dopaminergic tone. With Shkvatsabaya, Yurenev and Davison, we found that relaxation therapy improved the

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Increased plasma catecholamine concentrations and vas deferens norepinephrine biosynthesis in men with elevated blood pressure.

Cited by 52 publications

References 27 publications

Dissociation of 24-hour catecholamine levels from blood pressure in older men.

Dissociation of 24-hour catecholamine levels from blood pressure in older men.

Norepinephrine-Synthesizing Enzymes in Brain, Adrenals and Peripheral Sympathetic Nerves of Spontaneously Hypertensive Rats

The sympathetic nervous system: the muse of primary hypertension

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