Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction

Befekadu, Rahel; Christiansen, K.B.; Larsson, Anders; Grenegård, Magnus

doi:10.5603/cj.a2018.0030

Cited by 16 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The levels of several cathepsins are elevated in cancer cells and tumor-associated cells, and increased secretion from tumors has been shown [5][6][7]. Also, cathepsins B, K, L and S are implicated in cardiovascular disease [8][9][10][11][12][13]. In addition, cathepsin B, L and S play important roles in the major histocompatibility complex (MHC) class II-mediated antigen processing and presentation [14][15][16].…”

Section: Cysteine Proteasesmentioning

confidence: 99%

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

et al. 2017

View full text Add to dashboard Cite

Section: Cysteine Proteasesmentioning

confidence: 99%

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

et al. 2017

View full text Add to dashboard Cite

“…Activation of these signaling molecules is controlled by the transduction pathway (activated by binding of secreted factors to cell membrane receptors) and the mechanotransduction pathway (induced by changes in the rigidity of the extracellular matrix), which acts as an anchor for most cells, playing a key role in response to injury and stress) [17,19]. These molecules differ from structural proteins such as integrins, and bind transiently to specific receptors for intracellular signaling, including thrombospondin 1, to regulate tissue perfusion [20]. Largely, it can be said that the redox system also plays a role in repair of the extracellular matrix in diseases such as diabetes, either directly or via cell signaling [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

A single-center prospective pilot open-label study to assess the efficacy of topical application of an oxygen-enriched oil for the treatment of angular cheilitis

et al. 2022

View full text Add to dashboard Cite

Purpose:The aim of this pilot study was to clarify the acceptability and clinical efficacy of an oxygen-enriched oil-based gel for treatment of angular cheilitis. Methods: A class IIb medical preparation, packaged in appropriate syringes, was tested. Patients were instructed how to use the gel for 10 days: finger rub application (3 times daily) on the dried lesion after meals, without eating, drinking, or speaking for at least 30 min thereafter. The Wilcoxon signed-rank test was used to assess whether there were any differences in the distributions of reported pain and lesion dimension. A microbiological examination was also performed with oral swabs; chi-squared test was used to compare the difference in the presence of microorganisms before and after treatment. Results: Thirty patients were treated. A significant improvement in reported outcome and a significant reduction in the initially measured largest dimension of the lesion were observed after use of the clinical protocol. Additionally, a significant reduction in the pathogen count was found. Conclusion:Even if with limitations, data showed that this medical preparation facilitated prompt recovery from reported pain, without adverse reactions. Further work with a larger study population, and possibly a randomized control medication, will be needed.

show abstract

“…One study reported that TSP-1 could have a protective role in preventing the expansion of healing myocardial infarcts [ 24 ], but another stated that low TSP-1 could be associated with major adverse cardiac events in ST-elevation myocardial infarction [ 25 ]. Befekadu et al [ 26 ] found TSP-1 rapidly declined after P CI even significantly lower than in healthy individuals. TSP-1 could probably be unrelated to infarct size of heart.…”

Section: Discussionmentioning

confidence: 99%

Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction

Liao

Pan

et al. 2021

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Objectives Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias. Methods A total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital. Results Twenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p < 0.001) than those without AA. AA patients also tended to be elderly (65.25 ± 9.98 years vs 57.47 ± 10.78 years, p < 0.001), had higher Hs-CRP (39.74 ± 43.50 mg/L vs 12.22 ± 19.25 mg/L, p < 0.001) and worse heart function. TSP-1 (OR 1.033; 95% CI 1.003–1.065, p = 0.034), Hs-CRP (OR 1.023; 95% CI 1.006–1.041, p = 0.008), age (OR 1.067; 95% CI 1.004–1.135, p = 0.038) and LVDd (OR 1.142; 95% CI 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients. Conclusion TSP-1 is a potential novel indicator of atrial arrhythmias during AMI. Graphical abstract

show abstract

Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction

Abstract: Background: The role of cathepsins in the pathological progression of atherosclerotic lesions

Cited by 16 publications

References 31 publications

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

A single-center prospective pilot open-label study to assess the efficacy of topical application of an oxygen-enriched oil for the treatment of angular cheilitis

Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction

Contact Info

Product

Resources

About