Increased Plasma Concentrations of Circulating Intercellular Adhesion Molecule-1 (cICAM-1) in Patients with Necrotizing Pancreatitis

Kaufmann, Peter; Tilz, Gernot P.; Smolle, K. H.; Demel, Ulrike; Krejs, G. J.

doi:10.1016/s0171-2985(96)80040-4

Cited by 42 publications

(20 citation statements)

References 24 publications

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“…The soluble form of the adhesion molecule (sICAM-1) increases during inflammation and acute pancreatitis. An enhanced plasma release was observed in the early stage of necrotizing disease, demonstrating a sensitivity and specificity of 75 and 85%, respectively [123]. Evidence Category.…”

Section: Adhesion Moleculesmentioning

confidence: 99%

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

et al. 2003

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Section: Adhesion Moleculesmentioning

confidence: 99%

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

et al. 2003

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“…In two experimental models of acute pancreatitis in mice (administration of cerulein or feeding a choline-deficient, ethionine-supplemented diet), ICAM-1 concentrations in serum, pancreas, and lung increase (15). Kaufman et al (16) also show that circulating concentrations of ICAM-1 are elevated in patients with severe pancreatitis. To confirm the pathophysiological role of the molecule, we used mice that do not express ICAM-1 and mice depleted of neutrophils by the administration of anti-neutrophil antibodies (15).…”

Section: Intercellular Adhesion Molecule-1 (Icam-1)mentioning

confidence: 98%

Are genetically modified mice useful for the understanding of acute pancreatitis?

Pastor¹,

Frossard²

2001

The FASEB Journal

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Treatment of patients with acute pancreatitis has greatly improved due to a better understanding of the pathophysiology of the disease. This pathophysiology includes the activation and release of pancreatic enzymes in the interstitium, the autodigestion of the pancreas, and a multiple organ dysfunction after their release into the systemic circulation. Moreover, significant evidence exists that synthesis and release of proinflammatory cytokines and chemokines are also responsible for the local injury and systemic dispersion of the inflammation. The use of knockout mice devoid of active pro-or anti-inflammatory mediators allows examination of the effects of a specific cytokine without any drawbacks induced by pharmacological manipulations. The results obtained from these genetically modified mice show that numerous mediators have a major role in the pathophysiology of acute pancreatitis. They also clearly demonstrate that a single genetic deletion cannot completely prevent the occurrence of pancreatic or distant organ injury. However, the fact that the immune system is characterized by redundancies of ligands and receptors complicates the full understanding of each report. The utility of such experimental models might have limitations, and a full extrapolation of experimental data from genetically modified mice to humans must be done with caution.

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“…Kinetic studies demonstrated CRP levels elevate on post-operative day (POD) 1, peak from POD2 to POD3, and decline by POD5 provided that there is no complication or infection. Four reports suggest a persistent threshold of greater than 100 mg/L might indicate abscess/septic complications [254][255][256][257]; other studies have refuted this conclusion, leaving uncertainty for clinical utility [258][259][260][261][262].…”

Section: Statement 44mentioning

confidence: 99%

Management of Intra-Abdominal Infections

Moore

2016

Common Problems in Acute Care Surgery

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This paper reports on the consensus conference on the management of intra-abdominal infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual World Society of Emergency Surgery (WSES) meeting. This document covers all aspects of the management of IAIs. The Grading of Recommendations Assessment, Development and Evaluation recommendation is used, and this document represents the executive summary of the consensus conference findings.

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Increased Plasma Concentrations of Circulating Intercellular Adhesion Molecule-1 (cICAM-1) in Patients with Necrotizing Pancreatitis

Cited by 42 publications

References 24 publications

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

Useful Markers for Predicting Severity and Monitoring Progression of Acute Pancreatitis

Are genetically modified mice useful for the understanding of acute pancreatitis?

Management of Intra-Abdominal Infections

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