Increased plasma concentrations of intercellular adhesion molecule-1 after strenuous exercise associated with muscle damage

Abstract

Intercellular adhesion molecule-1 (ICAM-1) plays an important role in leukocyte migration from the circulation and intervention at sites of inflammation. We investigated the effects of various types of exercise on circulating levels of soluble ICAM-1 (sICAM-1) in normal healthy male adults. Plasma concentrations of sICAM-1 were measured before and after bicycle ergometer exercise at intensity of 80% maximal oxygen consumption (VO2mag) (16 min), 42 km endurance running and 30-min downhill running at intensity of ventilation threshold (VT). The plasma sICAM-1 level increased 1 day after the endurance running (12%) and downhill running (14%), but not after ergometer exercise. Plasma C-reactive protein (CRP) and creatine kinase (CK) concentrations also increased 1 day after running. Our data suggest that exercise associated with muscle damage and/or inflammation results in increased levels of plasma sICAM-1. The physiological significance of post-exercise high plasma sICAM-1 levels is not clear at this stage, but changes in plasma sICAM-1 may reflect the status of the immune system.

Peripheral blood leucocyte functional responses to acute eccentric exercise in humans are influenced by systemic stress, but not by exercise-induced muscle damage

“…Previous work has reported no change in neutrophil CD11b expression following moderate, sustained cycle ergometry exercise [35] and sub-maximal running exercise [36]. However, there is evidence that increases in neutrophil and monocyte CD11b and CD64 expression and in the concentration of circulating intercellular adhesion molecule-1 (ICAM-1) are influenced by the extent of muscle fibre injury after eccentric exercise [16,34,37]. This seems feasible, as increased expression of cell surface adhesion molecules could mediate the migration and infiltration of neutrophils and monocytes into exercise-damaged tissue, in which they contribute to the repair\regeneration process.…”

Changes in Endothelial Markers during a Summer Ultra-Endurance Road Cycling Event in the Heat

“…In thermoneutral conditions, circulating concentrations of ICAM1 increase following half (21.1 km) and full (42.2 km) marathons run events [14]. But not after low impact ergometer cycling [3], and has been associated with muscle damage seen during high impact exercises [14,48]. However, a previous study showed no changes in ICAM1 after a low impact cycling ergometer test [3].…”

Granulocytosis and increased adhesion molecules after resistive loading of the diaphragm

“…Previous studies have shown that exercise can induce increases in soluble (s) ICAM-1 levels in the plasma [12,38]. AKIMOTO et al [12] measured plasma concentrations of sICAM-1 before and after three types of exercise.…”

“…Previous studies have shown that exercise can induce increases in soluble (s) ICAM-1 levels in the plasma [12,38]. AKIMOTO et al [12] measured plasma concentrations of sICAM-1 before and after three types of exercise. The plasma concentration of sICAM-1, 1 day after a 42-km run or a downhill run, was significantly increased, whereas high-intensity bicycle ergometer exercise did not influence plasma concentrations of sICAM-1.…”

“…The selective recruitment of leukocytes into traumatised tissue in a defined sequence [11] involves the combined action of multiple cell adhesion molecules, including intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1, that are expressed on the endothelium and which bind to LFA-1 and VLA-4 expressed on leukocytes, respectively [12,13].…”