Increased Plasma Ghrelin Levels in Chronic Renal Failure are not Associated with Hemodynamic Parameters

Abstract

Fasting plasma ghrelin concentrations are higher in CRF patients regardless of their need for hemodialysis compared to controls. The etiology of renal failure does not have any effect on plasma ghrelin levels. In addition, ghrelin levels are not associated with hemodynamic parameters in patients with CRF.

Plasma ghrelin concentrations are positively associated with carotid artery atherosclerosis in males

“…Carotid atherosclerosis in the females was less advanced compared with the males of same age, as indicated by the lower IMT‐values and lower number of carotid atherosclerotic plaques in females compared with males. It is known that in severe kidney diseases ghrelin clearance is diminished leading to elevated ghrelin concentrations [30], and therefore it can be speculated that atherosclerosis‐induced dysfunction of the pathways affecting ghrelin metabolism may cause such associations as we have reported in this study. To analyse this possibility, we tested whether there is any correlation between ghrelin levels and the biomarkers reflecting liver and renal function.…”

Is there association between acyl-ghrelin and inflammation in hemodialysis patients?

“…Estudos têm observado elevados níveis de grelina total em pacientes com DRC. 13,27,29,30 No entanto, é importante ressaltar que grande parte desses estudos relata as concentrações plasmáticas de grelina total e, no presente, analisamos apenas a fração acyl-grelina, que é orexígena, ao contrário da desacyl-grelina, que tem ação anorexígena e que compõe 90% da grelina total circulante.…”

Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility

“…The kidney is the primary site of ghrelin clearance, although ghrelin clearance is reduced at the late stage of rat sepsis (Wu et al, 2003). Plasma fasting total (Rodriguez Ayala et al, 2004;Jarkovská et al, 2005aJarkovská et al, , 2005bTentolouris et al, 2005;Iglesias et al, 2006;Chang et al, 2005;Barazzoni et al, 2008;Arbeiter et al, 2009), acyl (Yoshimoto et al, 2002;Pérez-Fontá n et al, 2004;Chang et al, 2005;Jarkovská et al, 2005a;Barazzoni et al, 2008), and des-acyl (Yoshimoto et al, 2002;Muscaritoli et al, 2007) ghrelin levels were all elevated in patients with CKD, regardless of the modality of therapy using either hemodialysis or peritoneal dialysis. Plasma GH and IGF-1 levels were also increased, but neither of them was shown to be associated with the elevated plasma ghrelin level in these patients (Jarkovská et al, 2005a).…”