Increased plasma IL-17, IL-31, and IL-33 levels in chronic spontaneous urticaria

Wei, Lin; Zhou, Qiongyan; Liu, Chunbo; Ying, Mengxia; Xu, Suling

doi:10.1038/s41598-017-18187-z

Cited by 72 publications

(86 citation statements)

References 39 publications

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“…TRPV1 is responsible for histaminedependent itch while TRPA1 is not. 6,12,[22][23][24][25] Generally speaking, TRPA1 acts as an important role for histamine-independent itch while TRPV1 are responsible for both histamine-dependent andindependent itch. However, AP18 (TRPA1 antagonist) showed no behavioral effects on histamine-induced itch.…”

Section: Differences and Similarities Between Trpv1 And Trpa1mentioning

confidence: 99%

“…s.c. injection of IL-31 can cause severe itch in rats. 23 Inhibiting the activity of IL-31 could reduce the severity of itch in patients with AD. 26,28 The DRG neurons co-express TRPV1 and IL-31R.…”

Section: Interleukin-31mentioning

confidence: 99%

“…6,23 Interestingly, in vitro, the culture of DRG accompanied by IL-31 for 3 days resulted in growth of neurons and nerve elongation which is closely related to itch. 23,32 28 IL-31 is involved in transmission of pruritus and promotion of inflammation.…”

Section: Interleukin-31mentioning

confidence: 99%

“…21 The similarity is that some cytokines including NGF, interleukin (IL)-4/IL-13 and IL-31-related itch acted through both TRPV1 and TRPA1. 6,12,[22][23][24][25] Generally speaking, TRPA1 acts as an important role for histamine-independent itch while TRPV1 are responsible for both histamine-dependent andindependent itch. 6,17 Figure 3.…”

Section: Differences and Similarities Between Trpv1 And Trpa1mentioning

confidence: 99%

“…As such, IL-31-induced itch requires the participation of TRPV1 and TRPA1. 6,23 Interestingly, in vitro, the culture of DRG accompanied by IL-31 for 3 days resulted in growth of neurons and nerve elongation which is closely related to itch. However, this phenomena was independent of TRPV1.…”

Section: Interleukin-31mentioning

confidence: 99%

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Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1

Xie

2018

The Journal of Dermatology

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Chronic itch with an itch–scratch vicious circle is a significant problem in a large amount of diseases. Some of these diseases, such as psoriasis, atopic dermatitis, prurigo nodularis, Sézary syndrome, uremic pruritus, diabetes and jaundice, are common. For a very long time, chronic itch has been a thorny problem with few effective treatments. Because of this, itch researchers and dermatologists seek to find the mechanisms among chronic itch, inflammatory cytokines and neurons. As an immediate area of research focus, we are going to find the peripheral cross‐talk between neurons and skin cells. Two receptors, named transient receptor potential channel vanilloid 1 and transient receptor potential channel ankyrin transmembrane protein 1, have been shown to play important roles in chronic itch. Many advances have been made so far this decade. This review talks about the updated mechanism of itch‐related inflammatory cytokines via transient receptor potential channels in cutaneous chronic itch and corresponding diseases. The search for itch‐related inflammatory mediators and the structure of transient receptor potential channels this decade could deepen our understanding of the mechanism of itch and help us find more treatments of chronic itch in the future.

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Section: Differences and Similarities Between Trpv1 And Trpa1mentioning

confidence: 99%

Section: Interleukin-31mentioning

confidence: 99%

Section: Interleukin-31mentioning

confidence: 99%

Section: Differences and Similarities Between Trpv1 And Trpa1mentioning

confidence: 99%

Section: Interleukin-31mentioning

confidence: 99%

See 3 more Smart Citations

Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1

Xie

2018

The Journal of Dermatology

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In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31

Karstarli Bakay,

Demir,

Cicek

et al. 2023

Clinical & Translational All

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BackgroundChronic spontaneous urticaria (CSU) is a common and disabling disease. Assessments of IgE and C‐reactive protein (CRP) are recommended in the diagnostic work‐up, but the role and clinical relevance of these biomarkers are not well characterized. Moreover, it remains unknown if elevated levels of IgE or CRP are linked to CSU microRNA (miRNA) signatures or interleukin 31 (IL‐31).MethodsWe measured IgE and CRP serum levels in 47 CSU patients (and 45 healthy controls) and determined CSU disease activity using the urticaria activity score (UAS7). Expression levels of miR‐155 and miR‐221 were assessed by RT‐PCR, and IL‐31 levels were determined by ELISA.ResultsTotal IgE and CRP levels were independently increased in CSU patients. IgE and CRP levels were highest and lowest in patients with high and mild disease activity. IgE levels correlated with miR‐155 levels, whereas CRP levels correlated with miR‐221 levels. miR‐155 and miR‐221 were significantly overexpressed in CSU patients. ROC analyses linked miRNA‐155 and CSU with a sensitivity of 79% and specificity of 87%, and miRNA‐221 and CSU with a sensitivity of 75% and specificity of 91%. High CRP and miR‐221 expression levels were linked to elevated levels of IgG anti‐TPO and IL‐31.ConclusionIgE and CRP are useful biomarkers for disease activity in CSU, with distinct miRNA profiles. High CRP and miR‐221 levels may point to autoimmune CSU and a role for IL‐31.

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The correlation between Th17/Treg immune dysregulation and the disease severity in chronic spontaneous urticaria patients

Yang

Wang

et al. 2023

Immunity Inflam & Disease

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Objective Chronic spontaneous urticaria (CSU) has a profound impact on the sleep quality, productivity and overall quality of life of affected individuals. This study aimed to investigate the correlation between serum Th17/Treg immune dysregulation and the severity of CSU in patients. Methods Clinical baseline data of 120 CSU patients and matched healthy controls were recorded. The pruritus level, disease severity, and quality of life of CSU patients were assessed using the visual analogue scale, weekly Urticaria Activity Score and chronic urticaria quality of life questionnaire, respectively. The Th17/Treg cell ratio was detected by flow cytometry. ELISA was used to measure the levels of serum Th17 cytokines (IL‐17, IL‐21) and Treg cytokines (TGF‐β1, IL‐35). Pearson's correlation analysis was conducted to examine the associations between these indicators. Results No significant differences were identified in terms of sex, age, and BMI between the two groups. However, CSU patients exhibited a significant increase in the Th17 cell ratio, as well as the elevated serum levels of TGF‐β1, IL‐17 and, IL‐21. Conversely, the proportion of Treg cells and the levels of IL‐35 were remarkably decreased in CSU patients. Peripheral blood Th17 cells were negatively correlated with Treg cells. The severity of pruritus, life quality, and disease severity in CSU patients were positively correlated to Th17 cell ratio, and inversely correlated with Treg cell proportion. Conclusions A positive correlation was found between the percentage of peripheral blood Th17 cell in CSU patients and the pruritus level, life quality, and disease severity. In constrast, there was a negative correlation between the proportion of peripheral blood Treg cells and these clinical parameters.

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Increased plasma IL-17, IL-31, and IL-33 levels in chronic spontaneous urticaria

Cited by 72 publications

References 39 publications

Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1

Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1

In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31

The correlation between Th17/Treg immune dysregulation and the disease severity in chronic spontaneous urticaria patients

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