Increased plasma levels of endothelin-1 after cardiopulmonary bypass in patients with pulmonary hypertension and congenital heart disease

Komai, Hiroyoshi; Adatia, Ian; Elliott, Martin J.; Leval, Marc R. de; Haworth, Sheila G.

doi:10.1016/s0022-5223(19)34082-6

Cited by 112 publications

(50 citation statements)

References 23 publications

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“…These include reduced NO production (7,12), reduced NO synthase activity (19), reduced NO release, and increased NO inactivation (27). Finally, increased sensitivity to or increased release of such as endothelium‐derived contracting factors (18,28) may theoretically also operate post CPB. Our data do not help to differentiate between the various mechanisms operating in this complex interaction.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs

Glavind‐Kristensen¹,

Christensen

Toennesen

et al. 2002

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 99%

Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs

Glavind‐Kristensen¹,

Christensen

Toennesen

et al. 2002

Acta Anaesthesiol Scand

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“…Platelet activation during and after cardiac surgery with CPB also exhibits large variation (66–69). Like PMNs, the platelets also lose shape, show pseudopods and upregulation of adhesion molecules upon activation (70).…”

Section: Inflammatory Events Within the Bloodmentioning

confidence: 99%

The systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children

Christensen¹

2001

Acta Anaesthesiol Scand

144

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Paediatric cardiac surgery often requires cardiopulmonary bypass (CPB) during the surgical intervention. CPB is known to elicit a systemic inflammatory response with activation of the complement and coagulation systems, stimulation of cytokine production, cellular entrapment in organs, neutrophil activation with degranulation, platelet activation, and endothelial dysfunction. These changes are associated with a risk of postoperative organ dysfunction and increased morbidity and mortality in the postoperative period. Clinical studies have concentrated on measurement of inflammatory markers and mediators in peripheral blood, where the systemic inflammatory response in the paediatric cardiac patient seems to be different from the adult case. Looking at the organ level, experimental studies have the advantage of providing information contributing to a better understanding of the pathological events that may lead to the deteriorated organ function. This review focuses on the systemic inflammatory response after cardiac surgery with CPB in children and experimental CPB models.

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“…Increased endothelin levels have been found inconsistently in patients with PAH-CHD [86][87][88]. Increased endothelin levels have been correlated to a decreased pulmonary clearance after congenital heart surgery in patients with PAH-CHD [89][90][91]. In addition, to date there is still no meaningful evidence demonstrating receptor selectivity as clinically relevant [92].…”

Section: Endothelin-1 (Et-1) Receptor Antagonistsmentioning

confidence: 99%