Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study

Chew, Michelle; Linder, Adam; Santén, Stefan; Ersson, Anders; Herwald, Heiko; Thorlacius, Henrik

doi:10.1007/s00011-011-0422-6

Cited by 46 publications

(60 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the difference in HBP levels between infected and non-infected patients with ALI/ARDS was not significant, and neither was the difference in patients with septic and nonseptic shock. Our results are consistent with previous research demonstrating that HBP levels were notably enhanced in patients with shock regardless of whether they suffered from sepsis or not [24]. This is supported by the viewpoint that not only bacterial products [25] but also nonbacterial cross-linking of β 2 -integrins on the surface of neutrophils is sufficient to trigger HBP secretion [1].…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome

Lin

Shen

et al. 2013

Crit Care

View full text Add to dashboard Cite

IntroductionHeparin-binding protein (HBP) is an antimicrobial protein stored in neutrophil granules and plays a role in endothelial permeability regulation. The aim was to assess the diagnostic and prognostic value of measuring HBP in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).MethodsPlasma HBP was collected from 78 patients with ALI/ARDS, 28 patients with cardiogenic pulmonary edema (CPE) and 20 healthy volunteers at enrollment. Levels of HBP were measured by ELISA.ResultsPatients with ALI/ARDS had significantly higher median levels of HBP compared with patients with CPE (17.15 (11.95 to 24.07) ng/ml vs. 9.50 (7.98 to 12.18) ng/ml, P <0.001) at enrollment. There was no significant difference between CPE patients and healthy subjects in terms of HBP value (P = 0.372). The HBP levels of nonsurvivors was significantly higher than that of survivors (23.90 (14.81 to 32.45) ng/ml vs. 16.01 (10.97 to 21.06) ng/ml, P = 0.012) and multivariate logistic regression showed HBP (odds ratio =1.52, P = 0.034) was the independent predictor for 30-day mortality in patients with ALI/ARDS.ConclusionsPlasma HBP levels of ALI/ARDS patients were significantly higher than that of CPE patients. HBP was a strong prognostic marker for short-term mortality in ALI/ARDS.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Nevertheless, another study showed that HBP levels did not correlate with survival in nonseptic and septic shock patients [24]. HBP has been shown to increase the survival of cultured monocytes and protect them from oxidative stress [4,26].…”

Section: Discussionmentioning

confidence: 99%

Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome

Lin

Shen

et al. 2013

Crit Care

View full text Add to dashboard Cite

show abstract

“…Both HBP and MPO peaked during CPB but had a rapid decline. The levels were still high four hours after surgery, with levels comparable to those measured during septic conditions 124,151,152 .…”

Section: Heparin Reversal With Protaminesupporting

confidence: 48%

“…HBP is a multifunctional protein mainly released from activated neutrophils 123 . During systemic inflammation plasma levels of HBP increases 124 . HBP exerts pro-inflammatory effects 125 and is a potent inducer of vascular permeability and leukocyte recruitment 126 which are considered to contribute to organ injury and organ dysfunction.…”

Section: Fibrinolysismentioning

confidence: 99%

Hemostatic function and inflammatory activation after weaning from cardio pulmonary bypass

Olsson¹

2018

Linköping University Medical Dissertations

View full text Add to dashboard Cite

“…Heparin-binding protein has been reported as a potential biomarker of severe sepsis and septic shock (Linder et al, 2009, 2012; Chew et al, 2012) and as an indicator of vascular leakage (Johansson et al, 2009). A comparison of serum HBP levels between patients with S. suis -associated STSS versus patients without STSS or healthy individuals revealed that the serum HBP levels in patients with STSS were significantly higher than those in patients with meningitis or healthy controls (46.61 ± 9.49 ng/mL vs. 11.52 ± 5.20 ng/mL or 1.84 ± 0.96 ng/mL, respectively; P = 0.0007, Figure 1 ), which suggested that HBP is released during the progression of STSS in patients infected with S. suis .…”

Section: Resultsmentioning

confidence: 99%

Suilysin Stimulates the Release of Heparin Binding Protein from Neutrophils and Increases Vascular Permeability in Mice

Chen

Xie

et al. 2016

Front. Microbiol.

View full text Add to dashboard Cite

Most of the deaths that occurred during two large outbreaks of Streptococcus suis infections in 1998 and 2005 in China were caused by streptococcal toxic shock syndrome (STSS), which is characterized by increased vascular permeability. Heparin-binding protein (HBP) is thought to mediate the vascular leakage. The purpose of this study was to investigate the detailed mechanism underlying the release of HBP and the vascular leakage induced by S. suis. Significantly higher serum levels of HBP were detected in Chinese patients with STSS than in patients with meningitis or healthy controls. Suilysin (SLY) is an exotoxin secreted by the highly virulent strain 05ZYH33, and it stimulated the release of HBP from the polymorphonuclear neutrophils and mediated vascular leakage in mice. The release of HBP induced by SLY was caused by a calcium influx-dependent degranulation. Analyses using a pharmacological approach revealed that the release of HBP induced by SLY was related to Toll-like receptor 4, p38 mitogen-activated protein kinase, and the 1-phosphatidylinositol 3-kinase pathway. It was also dependent on a G protein-coupled seven-membrane spanning receptor. The results of this study provide new insights into the vascular leakage in STSS associated with non-Group A streptococci, which could lead to the discovery of potential therapeutic targets for STSS associated with S. suis.

show abstract

Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study

Abstract: HBP is elevated in patients with shock from septic and non-septic etiologies. Future investigations are required to define the functional role of HBP in patients with shock.

Cited by 46 publications

References 16 publications

Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome

Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome

Hemostatic function and inflammatory activation after weaning from cardio pulmonary bypass

Suilysin Stimulates the Release of Heparin Binding Protein from Neutrophils and Increases Vascular Permeability in Mice

Contact Info

Product

Resources

About