Increased plasma levels of thioredoxin-1 in patients with first episode psychosis and long-term schizophrenia

Owe‐Larsson, Björn; Ekdahl, Karin; Edbom, Tobias; Ösby, Urban; Karlsson, Håkan; Lundberg, Christer; Lundberg, Magnus

doi:10.1016/j.pnpbp.2011.03.012

Cited by 33 publications

(25 citation statements)

References 21 publications

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“…Psychotic patients in general are in a significantly increased longterm con dition of oxidative stress [102,103] . Oxidative stress markers, such as pentosidine [104] , glycer-AGE [105] and thiobarbituric acid reactive substances [103,106] were found to be higher among people with Sz and carbonyl stress was found to be lower in people with the disorder [104,105,107] .…”

Section: Metabolismmentioning

confidence: 99%

“…Oxidative stress markers, such as pentosidine [104] , glycer-AGE [105] and thiobarbituric acid reactive substances [103,106] were found to be higher among people with Sz and carbonyl stress was found to be lower in people with the disorder [104,105,107] . However, those oxidative markers have overlapping levels between people with Sz and healthy individuals, suggesting the discriminability of those markers is low [102] . One group suggested that only a subgroup of study participants with the glyoxalase Ⅰ (GLO1) deficits showed distinct patterns of oxidative stress abnormality in the plasma [104] , suggesting GLO1 deficits and oxidative stress may contribute to development of a certain subtype of Sz.…”

Section: Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Lai

Scarr

Udawela

et al. 2016

WJP

140

108

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Identifying biomarkers that can be used as diagnostics or predictors of treatment response (theranostics) in people with schizophrenia (Sz) will be an important step towards being able to provide personalized treatment. Findings from the studies in brain tissue have not yet been translated into biomarkers that are practical in clinical use because brain biopsies are not acceptable and neuroimaging techniques are expensive and the results are inconclusive. Thus, in recent years, there has been search for blood-based biomarkers for Sz as a valid alternative. Although there are some encouraging preliminary data to support the notion of peripheral biomarkers for Sz, it must be acknowledged that Sz is a complex and heterogeneous disorder which needs to be further dissected into subtype using biological based and clinical markers. The scope of this review is to critically examine published blood-based biomarker of Sz, focusing on possible uses for diagnosis, treatment response, or their relationship with schizophreniaassociated phenotype. We sorted the studies into six categories which include: (1) brain-derived neurotrophic factor; (2) inflammation and immune function; (3) neurochemistry; (4) oxidative stress response and metabolism; (5) epigenetics and microRNA; and (6) transcriptome and proteome studies. This review also summarized the molecules which have been conclusively reported as potential blood-based biomarkers for Sz in different blood cell types. Finally, we further discusses the pitfall of current blood-based studies and suggest that a prediction model-based, Sz specific, blood World Journal of Psychiatry W J P oriented study design as well as standardize blood collection conditions would be useful for Sz biomarker development.

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Section: Metabolismmentioning

confidence: 99%

Section: Metabolismmentioning

confidence: 99%

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Lai

Scarr

Udawela

et al. 2016

WJP

140

108

View full text Add to dashboard Cite

show abstract

“…Indeed, several studies have shown that sauna bathing induces hormonal changes which include lowering levels of cortisol by as much as 10-40% [25,26]. Oxidative stress is believed to be involved in the pathophysiology of stress disorders such as chronic fatigue syndrome as well as psychotic disorders [27]. Evidence also suggests that antioxidant depletion and increased oxidative stress are related to the extent of symptoms in chronic fatigue syndrome [28].…”

Section: Discussionmentioning

confidence: 99%

Sauna Bathing and Risk of Psychotic Disorders: A Prospective Cohort Study

Laukkanen

Kunutsor

2018

Med Princ Pract

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Objective: Sauna bathing has been suggested to promote mental well-being and relaxation, but the evidence is uncertain with respect to mental disorders. We aimed to assess the association of frequency of sauna bathing with risk of psychosis in the Kuopio Ischemic Heart Disease prospective population-based study. Subjects and Methods: Baseline sauna bathing habits were assessed in 2,138 men aged 42–61 years who had no history of psychotic disorders. Participants were classified into three groups based on the frequency of sauna bathing (once, 2–3, and 4–7 times per week). Results: During a median follow-up of 24.9 years, 203 psychotic disorders were recorded. A total of 537, 1,417, and 184 participants reported having a sauna bath once a week, 2–3 times, and 4–7 times per week, respectively. In Cox regression analysis adjusted for age, compared to men who had 1 sauna session per week, the hazard ratio (95% confidence intervals) of psychosis for 4–7 sauna sessions per week was 0.23 (0.09–0.58). In a multivariable model adjusted for several risk factors and other potential confounders, the corresponding hazard ratio was 0.21 (0.08–0.52). The association was similar after further adjustment for total energy intake, socioeconomic status, physical activity, and C-reactive protein (0.22 [0.09–0.54]) and was unchanged on additional adjustment for duration of a sauna session and temperature of the sauna bath (0.23 [0.09–0.57]). Conclusion: Our study suggests a strong inverse and independent association between frequent sauna bathing and the future risk of psychotic disorders in a general male population.

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“…2c). This is particularly interesting considering that Trx1 secretion [24,[97][98][99][100][101], as well as its nuclear translocation [24,[102][103][104][105][106][107] have been implicated in regulating cell proliferation, differentiation, and apoptosis. These findings imply that these proteins could be clinically applied as a therapeutic strategy to counteract the hypoxia/ischemia and reoxygenation damage.…”

Section: Discussionmentioning

confidence: 99%

Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia

Romero

Hanschmann

Gellert

et al. 2015

Biochimica et Biophysica Acta (BBA) - General Subjects

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Increased plasma levels of thioredoxin-1 in patients with first episode psychosis and long-term schizophrenia

Cited by 33 publications

References 21 publications

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Sauna Bathing and Risk of Psychotic Disorders: A Prospective Cohort Study

Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia

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