Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow

Ding, Yaodong; Pei, Yu-Qiang; Wu, Rui; Yang, Jiaxing; Zhao, Yali; Liu, Xiaoli; Shen, Hua; Ma, Qian; Zhang, Shuo; Ge, Hailong

doi:10.1186/s12872-020-01463-8

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…Pekdemir et al [ 19 ] reported diffuse intimal thickening and calcifications along epicardial arteries during coronary angiography examinations of patients with CSF. Ding et al [ 20 ] reported that lipoprotein-associated phospholipase A2, which plays a role in inflammation and atherosclerosis in the vessel walls, was significantly and independently associated with the presence of CSF. Considering the data obtained from these studies, it may be reasonable to conclude that diffuse coronary atherosclerosis plays a role in the etiopathogenesis of CSF.…”

Section: Discussionmentioning

confidence: 99%

Plasma atherogenic indices are independent predictors of slow coronary flow

Afşin

Kaya

Süner

et al. 2021

BMC Cardiovasc Disord

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Background Although the pathophysiology of coronary slow flow (CSF) has not been fully elucidated, emerging data increasingly support potential role for subclinical diffuse atherosclerosis in the etiology of CSF. We aimed to investigate relationship between atherogenic indices and CSF. Methods 130 patients with CSF diagnosed according to Thrombolysis in Myocardial Infarction (TIMI)-frame count (TFC) method and 130 controls who had normal coronary flow (NCF) were included in this retrospective study. Atherogenic indices (atherogenic index of plasma [AIP], Castelli risk indices I and II [CRI-I and II]) were calculated using conventional lipid parameters. Results The logistic regression analyses demonstrated that AIP (OR, 5.463; 95% confidence interval [CI], 1.357–21.991; p = 0.017) and CRI-II (OR, 1.624; 95% CI, 1.138–2.319; p = 0.008) were independent predictors of CSF. Receiver operating characteristic analysis showed that the optimal cutoff value to predict the occurrence of CSF was 0.66 for AIP (sensitivity, 59%; specificity, 73%; area under curve [AUC], 0.695; p < 0.001) and 3.27 for CRI-II (sensitivity, 60%; specificity, 79%; AUC, 0.726; p < 0.001). Conclusions AIP and CRI-II levels were independent predictors of CSF. Prospective studies in larger cohorts of patients may elucidate the role of atherogenic dyslipidemia in the pathophysiology of CSF.

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Section: Discussionmentioning

confidence: 99%

Plasma atherogenic indices are independent predictors of slow coronary flow

Afşin

Kaya

Süner

et al. 2021

BMC Cardiovasc Disord

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“…Platelet-activating factor can promote platelet aggregation in the body, chemotaxis of neutrophils and mononuclear macrophages, and release of inflammatory mediators such as leukotriene, participate in the inflammatory response of the body, and promote the occurrence and progression of atherosclerotic plaques. Platelet-activating factor can be hydrolyzed by LP-PLA2 and then lose its biological activity, reduce the inflammatory response of the body, and have antiatherosclerosis and anti-inflammatory functions [ 25 , 26 ]. However, most clinical studies show that it mainly participates in the body's inflammatory response and plays a role in promoting the body's inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Serum LP-PLA2 and sST2 Levels and the Condition of Patients with Acute Heart Failure and Their Prognostic Value

Zhu

Ruan

Zhu

2021

Evidence-Based Complementary and Alternative Medicine

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Acute heart failure (AHF) occurs mostly in the elderly, which is a syndrome that occurs in the later stages of the development of cardiovascular disease. Due to the sharp decline in the patient’s heart function, the patient has a high mortality rate and a poor prognosis, which seriously threaten the life safety of the elderly. Therefore, early diagnosis of AHF and timely treatment are extremely important. Lipoprotein-associated phospholipase A2 (LP-PLA2) is a newly discovered cardiovascular-specific inflammatory marker, which is closely related to the formation and progression of atherosclerotic plaque and the occurrence and development of coronary heart disease. Soluble growth stimulation expression gene 2 (sST2) protein is a protein produced under the induction of mechanical stress in cardiomyocytes. It can act as a decoy receptor to mediate the interleukin-33 (IL-33)/ST2 signaling pathway to bind to IL-33, thereby reducing the myocardial protective effect and leading to myocardial remodeling. The purpose of this study was to explore the serum LP-PLA2 and sST2 levels in AHF patients and to analyze their correlation with the disease and their prognostic value. The results showed that the levels of serum LP-PLA2 and sST2 were increased in AHF patients, and the levels of serum LP-PLA2 and sST2 in patients with adverse prognostic events were higher than those in patients without adverse prognostic events. The levels of serum LP-PLA2 and sST2 are closely related to the degree of patients’ illness, among which the combined prediction of AHF patients with LP-PLA2 and sST2 has the highest value, which is worthy of promotion.

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“…Several possible mechanisms have been proposed, such as the endothelial dysfunction theory 28 , early atherosclerosis 29 , microvascular disease 5 , 30 , platelet dysfunction 31 , changes in hemorheology 32 , 33 , and oxidative stress and local/systemic inflammatory response 3 – 5 . Recently, some studies have indicated that lipoprotein-associated phospholipase A2 34 , plasma choline 35 , or serum salusin beta level 36 could be a predictive or diagnostic biomarker for CSF.…”

Section: Discussionmentioning

confidence: 99%

The effect of coronary slow flow on left atrial structure and function

Shui

Sun

Gao

et al. 2021

Sci Rep

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The coronary slow flow phenomenon (CSFP) is common in coronary angiography, however its impact on left atrial (LA) function is still controversial. This study aims to evaluate the LA structure and function of patients with CSFP using two-dimensional speckle tracking echocardiography (2D-STE). Consecutive patients scheduled for coronary angiography from January 2016 to September 2017 were enrolled in this study. Patients’ demographic data, clinical histories, laboratory and angiographic findings were collected and recorded. Diagnostic criteria for CSFP is based on Beltrame et al. proposed in 2012. Meanwhile 139 patients who have no significant stenosis (≤ 40%) and normal blood flow were selected as control. All patients received an echocardiographic examination 24 h before coronary angiography. LA structure and function were measured with echocardiography and 2D-STE. Our results showed that among the 1,954 patients who had received coronary angiography, 512 patients were included in the analysis after the exclusion criteria was implemented. Of those, 101 patients met the CSFP criteria (5.5%). CSFP is mainly seen in LAD (~ 70%). There was no statistical difference in baseline characteristics between the CSFP group and control group, except for a higher proportion of smokers in the CSFP group (P = 0.001). The percentage of monocytes is an independent risk factor for the occurrence of CSFP (P = 0.036) after binary logistic regression analysis. The LA global longitudinal strain (LA-GLS, represents reservoir functions) decreased and LA strain rate at late diastole (LA-SRa, represents booster function) increased in patients with CSFP compared to the control group (P < 0.05). Correlation test of continuous variables by Pearson test suggested that LA-GLS was negatively correlated with TIMI frame count (TFC). We concluded that the percentage of monocytes is an independent risk factor for the CSFP; the LA reservoir and booster functions were impaired in patients with CSFP; LA-GLS is negatively correlated with TFC.

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Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow

Cited by 9 publications

References 30 publications

Plasma atherogenic indices are independent predictors of slow coronary flow

Plasma atherogenic indices are independent predictors of slow coronary flow

Correlation between Serum LP-PLA2 and sST2 Levels and the Condition of Patients with Acute Heart Failure and Their Prognostic Value

The effect of coronary slow flow on left atrial structure and function

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