Increased Plasma Malondialdehyde in Patients with Viral Cirrhosis and Its Relationships to Plasma Nitric Oxide, Endotoxin, and Portal Pressure

Lee, Kuei–Chuan; Yang, Ying‐Ying; Wang, Yingwen; Lee, Fa-Yauh; Loong, Che‐Chuan; Hou, Ming‐Chih; H, Lin; Lee, Shou‐Dong

doi:10.1007/s10620-009-0990-2

Cited by 26 publications

(15 citation statements)

References 41 publications

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“…In PCA rats, a preserved oxidant/antioxidant balance was demonstrated with no changes in oxidant and antioxidant enzyme activities. Our results suggest systemic oxidative stress is a result of primary liver injury; a common finding observed in various types of liver disease such as nonalcoholic fatty liver disease, alcoholic liver disease, and viral hepatitis [39], [40] and [41], as well as cirrhosis [42], [43] and [44].…”

Section: Discussionmentioning

confidence: 94%

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

Bosoi

Yang

Huynh

et al. 2012

Free Radical Biology and Medicine

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Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and HE severity remains controversial. It is believed oxidative stress plays a role in modulating the effects of hyperammonemia. This study aimed to determine the relationship between chronic hyperammonemia, oxidative stress, and brain edema (BE) in two rat models of HE: portacaval anastomosis (PCA) and bile-duct ligation (BDL). Ammonia and reactive oxygen species (ROS) levels, BE, oxidant and antioxidant enzyme activities, as well as lipid peroxidation were assessed both systemically and centrally in these two different animal models. Then, the effects of allopurinol (xanthine oxidase inhibitor, 100 mg/kg for 10 days) on ROS and BE and the temporal resolution of ammonia, ROS, and BE were evaluated only in BDL rats. Similar arterial and cerebrospinal fluid ammonia levels were found in PCA and BDL rats, both significantly higher compared to their respective sham-operated controls (p < 0.05). BE was detected in BDL rats (p < 0.05) but not in PCA rats. Evidence of oxidative stress was found systemically but not centrally in BDL rats: increased levels of ROS, increased activity of xanthine oxidase (oxidant enzyme), enhanced oxidative modifications on lipids, as well as decreased antioxidant defense. In PCA rats, a preserved oxidant/antioxidant balance was demonstrated. Treatment with allopurinol in BDL rats attenuated both ROS and BE, suggesting systemic oxidative stress is implicated in the pathogenesis of BE. Analysis of ROS and ammonia temporal resolution in the plasma of BDL rats suggests systemic oxidative stress might be an important "first hit", which, followed by increases in ammonia, leads to BE in chronic liver failure. In conclusion, chronic hyperammonemia and oxidative stress in combination lead to the onset of BE in rats with chronic liver failure. HIGHLIGHTS► Hyperammonemia does not lead independently to brain edema in chronic liver failure. ► Systemic oxidative stress plays a role in brain edema in chronic liver failure. ► Systemic oxidative stress induces brain edema synergistically with hyperammonemia. ► Systemic oxidative stress is an important "first hit" in chronic liver failure.

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Section: Discussionmentioning

confidence: 94%

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

Bosoi

Yang

Huynh

et al. 2012

Free Radical Biology and Medicine

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“…The current understanding of the pathophysiology of renal dysfunction in advanced liver failure is that the relative systemic hypovolaemia because of portal hypertension and splanchnic vasodilation activates compensatory mechanisms such as sympathetic nervous system and renin‐angiotensin‐aldosterone system . Additional factors may deteriorate this haemodynamic scenario such as bacterial traslocation , bacterial infections and oxidative stress leading to renal failure and increased mortality . These abnormalities are common and progressive with the severity of the disease .…”

Section: Discussionmentioning

confidence: 99%

Albumin infusion improves renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury

García-Martinez

Noiret

Sen

et al. 2014

Liver International

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“…et al, 1995). Further, plasma levels of the bacterial endotoxins in cirrhotic patients were significantly positively associated with hepatic venous pressure gradient, wedge hepatic venous pressure, and hepatic sinusoid resistance (Lee K.C., 2010).…”

Section: Discussionmentioning

confidence: 92%

The Bacterial Endotoxins Levels in the Blood of Cirrhotic Patients as Predictor of the Risk of Esophageal Varices Bleeding

Garbuzenko¹,

Микуров²,

Smirnov³

2012

Portal Hypertension - Causes and Complications

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Increased Plasma Malondialdehyde in Patients with Viral Cirrhosis and Its Relationships to Plasma Nitric Oxide, Endotoxin, and Portal Pressure

Abstract: This study suggests a close interaction among MDA, endotoxin, and NOx and that these substances are also associated with hemodynamic derangement in cirrhosis.

Cited by 26 publications

References 41 publications

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

Albumin infusion improves renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury

The Bacterial Endotoxins Levels in the Blood of Cirrhotic Patients as Predictor of the Risk of Esophageal Varices Bleeding

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