Increased plasma N‐terminal pro‐B‐type natriuretic peptide and markers of inflammation related to atherosclerosis in patients with primary hyperparathyroidism

Øgard, Christina Gerlach; Engelmann, Mads D.M.; Kistorp, Caroline; Nielsen, Steen Levin; Vestergaard, Henrik

doi:10.1111/j.1365-2265.2005.02363.x

Cited by 59 publications

(59 citation statements)

References 48 publications

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“…8,[24][25][26][27] Third, higher PTH is associated with both established cardiovascular risk factors 28,29 and more recently described risk factors such as markers of inflammation, renal dysfunction, and cardiac pathology. 8,30,31 The fact that PTH was consistently associated with atherosclerotic disease and death in all multivariable models suggests that confounding by these other factors is not the sole explanation for our findings. Moreover, the results from the WBMRA provide further support of previous data of PTH being associated to subclinical and clinical atherosclerotic diseases.…”

Section: Potential Mechanismsmentioning

confidence: 59%

Plasma–Parathyroid Hormone Is Associated With Subclinical and Clinical Atherosclerotic Disease in 2 Community-Based Cohorts

Hagström

Michaëlsson

Melhus

et al. 2014

ATVB

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Objective— Cardiovascular risk factors have different impact on different arterial territories. Diseases with elevated circulating parathyroid hormone (PTH) such as primary hyperparathyroidism and chronic renal failure have been shown to be associated with an increased risk of cardiovascular disease, predominantly heart or cerebrovascular diseases. However, data on the associations between circulating PTH and peripheral atherosclerosis are limited. Approach and Results— Two prospective, community-based studies were used. In 306 men and women, who were 70 years old, from the Prospective investigation of the vasculature in Uppsala seniors (PIVUS) study, cross-sectional relations between PTH and atherosclerotic burden assessed by whole-body magnetic resonance angiography were investigated. In 998 men, who were 71 years old, from the Uppsala longitudinal study of adult men (ULSAM) study, the association between PTH concentration and risk of subsequent nonfatal atherosclerotic disease (excluding coronary or cerebrovascular disease) was investigated. Adjusting for established vascular risk factors, PTH was associated with burden of atherosclerosis (increase in total atherosclerotic score per SD PTH increase: 0.04, 0.003–0.08; P =0.03) in the PIVUS study. During follow-up in the ULSAM study (median 16.7 years), 89 men were diagnosed with nonfatal atherosclerotic disease. In Cox-regression analyses adjusting for established vascular risk factors and mineral metabolism, higher PTH was associated with an increased risk of nonfatal atherosclerotic disease (hazard ratio for 1 SD increase of PTH: 1.55, 1.33–1.88; P <0.0001). Results were similar when including fatal atherosclerotic disease in the outcome. Conclusions— In 2 independent community-based cohorts, PTH was associated to the degree of atherosclerosis and risk of clinically overt atherosclerotic disease, respectively. Our data confirm and extend previous studies supporting a role for PTH in the development of atherosclerotic disease.

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Section: Potential Mechanismsmentioning

confidence: 59%

Plasma–Parathyroid Hormone Is Associated With Subclinical and Clinical Atherosclerotic Disease in 2 Community-Based Cohorts

Hagström

Michaëlsson

Melhus

et al. 2014

ATVB

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“…Significant association has been found between PTH and vitamin D classifications. Former study showed that the PTH level was higher in those subjects who had low vitamin D levels (Ogard et al, 2005). Calcium is essential for male reproductive functions that include hyperactivation, acrosomal reaction, spermatogenesis, and sperm motility.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men

et al. 2016

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SUMMARYAlthough vitamin D deficiency is one of the most common health problems throughout the world, including Iran, conflicting information exists on the potential association between serum vitamin D levels and semen quality. This study intended to evaluate the association between serum vitamin D [25(OH) D3] with semen quality and hormones in Iranian subfertile men. We also compared mean vitamin D and hormone levels in normospermic men with oligoasthenoteratozoospermia (OAT) men. This cross-sectional study was conducted on 278 men who were referred to Royan Infertility Clinic (Tehran, Iran) from March to September 2014. The participants were categorized into two groups; of 186 normospermic and 92 OAT patients according to World Health Organization 2010 criteria. Each participant provided informed consent prior to launching research. Participants completed two general questionnaires of nutritional status. Blood and semen samples were obtained for assessment, and all data were adjusted for age, body mass index (BMI), and season. Vitamin D levels were classified according to Institute of Medicine guidelines. Vitamin D deficiency, insufficiency, and normal levels were observed in 8.6%, 43.6%, 47.8% of participants, respectively. No association was found between daily dietary intake of vitamin D and calcium with sperm parameters. Serum vitamin D was inversely correlated with PTH (p < 0.045). In normospermic men, serum vitamin D levels categorized were not correlated with semen parameters and reproductive hormones (FSH, LH, testosterone(T), and FT), whereas sperm motility showed a positive correlation with vitamin D categorized in OAT men (rs = 0.131, p = 0.028). In conclusion, there was a high incidence of deficiency and insufficiency 25(OH) D Levels (<20ng/ml) observed in Iranian men (52.2%). Moreover, our findings showed a correlation between vitamin D levels and sperm motility in OAT men, which requires further studies.

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“…6,29,30 Second, PTH appears also to have detrimental effects on the myocardium via induction of left ventricular hypertrophy, cardiac calcification, and fibrosis. 5,9,[31][32][33] Third, higher PTH is associated with both established cardiovascular risk factors 8,34 and more recently described risk factors such as inflammation markers, 35 renal dysfunction, 36 and cardiac pathology. 2,35,37 The fact that PTH remained significantly associated with CVD mortality in all multivariable models suggests that confounding by these factors is not the sole explanation for our findings.…”

Section: Potential Mechanismsmentioning

confidence: 99%

Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community

et al. 2009

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Increased plasma N‐terminal pro‐B‐type natriuretic peptide and markers of inflammation related to atherosclerosis in patients with primary hyperparathyroidism

Cited by 59 publications

References 48 publications

Plasma–Parathyroid Hormone Is Associated With Subclinical and Clinical Atherosclerotic Disease in 2 Community-Based Cohorts

Plasma–Parathyroid Hormone Is Associated With Subclinical and Clinical Atherosclerotic Disease in 2 Community-Based Cohorts

Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men

Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community

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