Increased plasma neurotensin concentrations in patients with Parkinson's disease

Abstract

Plasma neurotensin (NT) was measured by radioimmunoassay in propanol extracted and unextracted plasma from 16 parkinsonian patients (four before treatment) and 16 age and sex matched controls. Mean plasma NT concentrations were consistently higher in parkinsonian patients than in controls and higher in the four untreated patients than in levodopa treated patients suggesting that plasma NT measurement may represent an easy detectable additional index in diagnosing parkinsonism and provides a novel approach to research in this field. (J Neurol Neurosurg Psychiatry 2001;70:784-786)

Emerging role of neurotensin in regulation of the cardiovascular system

“…including visceral NT-secreting neuroendocrine tumors (neurotensinomas) (Calhoun et al, 2003), gastrointestinal motor abnormalities (Bardella et al, 2000), inflammatory dermatological disorders (Vasiadi et al, 2012(Vasiadi et al, , 2013, neurological disorders (Schimpff et al, 2001), psychiatric disease (Angelidou et al, 2010), and acute sympatho-adrenal activation in shock (Piliponsky et al, 2008) or neonatal asphyxia (Liu et al, 2007). Furthermore, high blood plasma levels of NT precursor (proneurotensin) have been revealed in morbidly obese subjects after bariatric surgery (ChristCrain et al 2006) or gastric bypass operation (Holdstock et al, 2008).…”

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

“…The authors also examined the effect of MPTP and calpain inhibition following MPTP administration on neurotensin expression. Neurotensin potentially blocks DA neurotransmission [142] and has been demonstrated to increase following MPTP administration in mice [143] and in human postmortem PD brain [144]. Calpain inhibition following MPTP treatment abrogated the increase in neurotensin expression caused by MPTP alone [141].…”

Modulation of the Interaction between Neurotensin Receptor NTS1 and Gq Protein by Lipid

“…NT displays a wide range of biological activities and plays important roles in hypothermia 13 , antinociception 14 , cancer cell growth 15 , modulation of dopamine neurotransmission 16 , and Parkinson’s disease 17 . Three neurotensin receptors, NTS1, NTS2 and NTS3 have been identified; NTS1 18 and NTS2 19,20 belong to the class A GPCR family, whereas NTS3 (or sortilin) is a member of the Vps10p family which has a single transmembrane domain 21 .…”