Increased plasma-soluble fibrin monomer levels in patients with disseminated intravascular coagulation

Wada, Hideo; Wakita, Yoshihiro; Nakase, Tutomu; Shimura, Minori; Hiyoyama, Katsuyo; Nagaya, S; Deguchi, Hiroshi; Mori, Yoshitaka; Kaneko, Toshihiro; Deguchi, Katsumi; Fujii, Junichi; Shiku, Hiroshi

doi:10.1002/(sici)1096-8652(199604)51:4<255::aid-ajh1>3.0.co;2-v

Cited by 77 publications

(61 citation statements)

References 19 publications

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“…Since the establishment of the Japanese diagnostic criteria for DIC by the JMHW [6] in 1987, many reports evaluated the efficacy of various drugs for DIC and the diagnostic usefulness of hemostatic molecular markers in DIC [8,11,19,21]. On the other hand, the ISTH/SSC meeting established the international diagnostic criteria for overt DIC [19] by modifying the JMHW diagnostic criteria.…”

Section: Discussionmentioning

confidence: 99%

“…The Japanese criteria are based on a scoring system based on the presence of underlying disease, bleeding, organ failure, and the results of global coagulation tests [fibrinogen, fibrin degradation products (FDP), platelet count, and prothrombin time (PT)]. Hemostatic molecular markers, such as D-dimer [7], soluble fibrin (SF) [8], thrombin-antithrombin complex (TAT) [9], plasmin-plasmin inhibitor complex (PPIC) [10], and thrombomodulin [11], can be also measured. However, the latter markers are very sensitive but not specific for DIC, and they cannot be measured in all hospitals.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis (ISTH) and of the Japanese Ministry of Health and Welfare for overt DIC

et al. 2003

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We compared the criteria set by the International Society of Thrombosis and Hemostasis (ISTH) for the diagnosis of disseminated intravascular coagulation (DIC) with the criteria of the Japanese Ministry of Health and Welfare (JMHW) set for the diagnosis of overt DIC. We studied 1,284 Japanese patients with DIC. The rate of agreement in the diagnosis of DIC by the two diagnostic systems was 67.4%. In addition, only 2.0% of non-DIC patients by JMHW criteria were diagnosed with overt DIC by ISTH criteria, suggesting that ISTH for overt DIC includes typical cases of DIC. The concordance of diagnosis for DIC by ISTH and JMHW was significantly high in patients with trauma or acute promyelocytic leukemia. About 70% of DIC or overt DIC patients had more than 1 point in the scoring system for prothrombin time, but >50% of those patients had 0 point for plasma fibrinogen level. Abnormal fibrin and fibrinogen degradation product (FDP) levels and platelet counts were observed in >88% of DIC and overt DIC patients but were observed in >50% of non-DIC patients, indicating that these parameters are sensitive markers but not specific markers for the diagnosis of DIC. Considered together, our results suggest that the diagnostic criteria for DIC and overt DIC could be improved by changing the cut-off values of the global coagulation tests. Am. J. Hematol. 74:17-22, 2003.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis (ISTH) and of the Japanese Ministry of Health and Welfare for overt DIC

et al. 2003

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“…D-dimer is reported to be a negative predictor for DVT and in Europe and North America, and D-dimer levels less than 0.5 mg/mL are indicative of absence of DVT/PE [16]. On the other hand, plasma levels of soluble fibrin (SF), produced by thrombin-catalyzed cleavage of fibrinogen, were reported to be significantly high in patients with DIC [18].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer

et al. 2005

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The present study was designed to determine the cutoff values of D-dimer and soluble fibrin (SF) for the diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) in Japanese patients. Plasma levels of these molecules were measured in 243 patients suspected of having DVT and 100 healthy volunteers (controls). Out of 243 patients, 20 patients were diagnosed with DVT. In the control group, plasma levels of D-dimer and SF did not show normal distribution, and the 95% confidence intervals (CI) of D-dimer and SF were 2.45 mg/mL and 6.92 mg/mL, respectively. Plasma levels of D-dimer and SF of patients with DVT were significantly higher than of those without DVT. In patients with DVT, the minimum values of D-dimer and SF were 1.71 and 1.44 mg/mL, respectively. When the cutoff value was set at the average + 1 SD of those of the control (D-dimer, about 1.8 mg/ mL; SF, about 1.4 mg/mL), 1 and 0 patient with DVT was overlooked, respectively. The sensitivity and specificity of D-dimer and SF for DVT were 95% and 100%, and 61.9% and 53.8%, respectively. When the cutoff value was set at 95% CI of the control (D-dimer, 2.5 mg/ mL; SF, 6.9 mg/mL), 2 and 9 patients with DVT were overlooked, respectively. The sensitivity and specificity of D-dimer and SF were 90% and 50%, and 77.6% and 88.3%, respectively. When the cutoff values set at 2.5 mg/mL of D-dimer or 6.9 mg/mL of SF, 1 DVT patient was overlooked, with sensitivity and specificity of 95% and 69.5%. Our data suggest that both D-dimer and SF are useful markers for the diagnosis of DVT and that measurement of both D-dimer and SF increases the sensitivity and specificity for the diagnosis of DVT/PE.

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“…Both criteria are scoring systems based on global coagulation tests such as fibrinogen, fibrinogen/fibrin degradation products (FDP), platelet counts, and prothrombin time (PT). Hemostatic molecular markers such as D-dimers [7], soluble fibrin (SF) [8], thrombin-antithrombin complex (TAT) [9], plasmin-plasmin inhibitor complex (PPIC) [10], and thrombomodulin (TM) [11] can be also measured. However, these latter markers are very sensitive but not specific for DIC.…”

Section: Introductionmentioning

confidence: 99%

Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit

et al. 2004

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We investigated the correlation between disseminated intravascular coagulation (DIC) score and hemostatic parameters and sepsis-related organ failure assessment (SOFA) score with clinical outcome of patients with DIC in an intensive care unit (ICU). The SOFA score was markedly elevated in patients with DIC relative to patients without DIC and significantly higher in non-survivors than in survivors. Abnormalities in almost all hemostatic parameters were significant in patients with DIC, but there was no significant difference in almost all hemostatic parameters between survivors and non-survivors. However, plasma antithrombin (AT) levels were significantly lower in non-survivors than in survivors. Soluble fibrin (SF) and tissue type plasminogen activator (tPA)-plasminogen activator inhibitor-I (PAI-I) complex correlated significantly with the SOFA score, whereas AT levels correlated significantly and negatively with the SOFA score. We conclude that the SOFA score is useful for predicting outcome in DIC patients in the ICU, and that hemostatic parameters, especially plasma AT levels, are also useful markers for organ failure and clinical outcome. Am.

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Increased plasma-soluble fibrin monomer levels in patients with disseminated intravascular coagulation

Cited by 77 publications

References 19 publications

Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis (ISTH) and of the Japanese Ministry of Health and Welfare for overt DIC

Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis (ISTH) and of the Japanese Ministry of Health and Welfare for overt DIC

Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer

Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit

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