Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

Cao, Xia; Xie, Xiang; Zhou, Jiansong; Yang, Peng; Wang, Yaqin; Chen, Zhiheng

doi:10.1038/hr.2012.62

Cited by 21 publications

(16 citation statements)

References 33 publications

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“…At variance with previous investigations on different pathological conditions [9][10][11][12][13][14], the results of this prospective study attest that a progressive decrease of MPV occurs in parallel with severity of MHT. This is not really unexpected, however, since a similar finding has been earlier published in a small study of six patients admitted as emergencies for generalized trauma after motor vehicle accident, who developed thrombocytopenia and experimented a remarkable decrease of MPV from 9.0 fl (range 8.5-9.8 fl) to 7.8 fl (range 7.3-8.7 fl; P < 0.01) in the following hours after hospital admission [15].…”

Section: Discussioncontrasting

confidence: 66%

“…ageing) [7], raised MPV may be due to release of larger and hyperactive platelets from the spleen rather than shape changes occurring in the circulation, whereas sudden MPV reductions may be attributable to in-vivo consumption of larger and more fragile platelets [8]. Several lines of evidence attest that increased MPV values are frequent in human disorders, including ischemic heart disease [9], stroke [10], venous thromboembolism [11], hypertension [12], metabolic syndrome [13] and cancer [14]. Conversely, reduced MPV has been occasionally observed in patients with generalized trauma [15] and sepsis [8].…”

Section: Introductionmentioning

confidence: 96%

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The mean platelet volume is decreased in patients with mild head trauma and brain injury

Lippi

Carbucicchio

Benatti

et al. 2013

Blood Coagulation &Amp; Fibrinolysis

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We planned a prospective study to assess platelet number and size in patients with or without brain injury after mild head trauma (MHT). Platelet count and mean platelet volume (MPV) were assessed in consecutive patients admitted to the emergency department with isolate MHT, as well as in healthy blood donors who served as controls. The study population consisted in 54 patients with MHT, 13 of whom (24%) with intracranial lesions suggestive for brain injury, and 339 healthy blood donors. The value of platelet count was significantly lower in patients with MHT and positive computerized tomography than in healthy controls (P = 0.014). The vales of MPV progressively decreased from healthy controls (11.1 fl) to patients with MHT and negative computerized tomography (9.8 fl; P < 0.001), and further to patients with MHT and positive computerized tomography (8.6 fl; P < 0.001). The MPV was significantly lower in patients with MHT and positive computerized tomography than in those with negative computerized tomography (P = 0.002). As compared with healthy controls, the frequency of decreased MPV values was 10-fold and 17-fold higher in MTH patients with negative and positive computerized tomography, respectively. The MPV exhibited an area under the curve of 0.74 (95% CI, 0.58 to 0.89; P < 0.001) for differentiating MHT patients with positive computerized tomography from those with negative computerized tomography. MHT patients display a larger prevalence of small and hyporeactive platelets. This observation provides a reliable basis for planning further studies to establish whether MPV may be useful for diagnostic evaluation of MHT in the emergency department.

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Section: Discussioncontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 96%

The mean platelet volume is decreased in patients with mild head trauma and brain injury

Lippi

Carbucicchio

Benatti

et al. 2013

Blood Coagulation &Amp; Fibrinolysis

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“…There were studies in which MPV was correlated with HTA (12) in diabetics, in stroke patients (48), and even in prehypertensive patients (49). In a recent study with hypertensives, a positive correlation with the degree of hypertensive retinopathy was shown (50).…”

Section: Discussionmentioning

confidence: 99%

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Güngör¹,

Gürsoy

Güngör³

et al. 2016

Turk J Med Sci

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IntroductionDiabetes mellitus (DM), a major global health problem, is commonly associated with increased risk of developing micro-and macrovascular disease. Despite its clinical importance, the pathophysiology of diabetic complications is not completely understood. Platelets have been thought to be involved in these complications. Diabetic retinopathy (DR) is one of those important complications and leads to a considerable increase in morbidity.Platelet volume is a marker of platelet activation and function that can be measured easily as mean platelet volume (MPV) by clinical analyzers. It is now known that larger platelets are more reactive and produce more prothrombotic factors (1,2). Increased MPV has been demonstrated in diabetes (3-9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10-17), diabetic neuropathy (18-20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3-5,26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing the production of more prothrombotic factors, or causing endothelium-dependent vasomotor dysfunction.Keeping in mind these complex relations between MPV, diabetes, and its complications, in the present study we aimed to: 1) compare the MPV in diabetic patients with that in healthy controls; 2) determine if there is a difference in MPV between diabetic patients with and without DR, and also with and without proliferative retinopathy; 3) compare MPV levels of diabetic patients with or without hypertension (HTA), hyperlipemia (HL), and HTA with HL, and 4) see if there is a correlation of MPV with HbA1c and body mass index (BMI) in diabetic patients. Material and methods PatientsA total of 102 type 2 DM (T2DM) patients [65 female (63.7%), 35 male (36.3%)], 50 of them without retinopathy [31 female (62.0%), 19 male (38.0%)] and 52 with retinopathy [34 female (65.4%), 18 male (34.6%)], aged 22-90 years, were recruited from the Clinic of Ankara Education and Research Hospital from June 2009 to June Background/aim: Patients with diabetes mellitus have an increased risk of developing micro-and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy.Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then checked to see if the mean platelet volume correlated with hemoglobin A1c and body mass index. Results:The mean platelet volume levels were higher in all diabetic patients, and they were highest in diabetics with retinopathy. The mean plate...

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“…3 Son zamanlarda MPV değerlerinin enflamasyonun saptanmasında önemli bir belirteç olarak kullanılabileceğini destekleyen çalışmalar artmaktadır. 6,7 Yaptığımız literatür taramasına göre akut CO zehirlenmesi olan çocuk yaş grubu hastalarda trombosit işlevlerini değerlendirmek için MPV değerlerini inceleyen bir çalışma tespit edilememiştir. Bu çalışmada akut CO zehirlenmesi olan çocuk hastalarda MPV değerlerinin değerlendirilmesi amaçlanmıştır.…”

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The Effect of Carbon Monoxide Poisoning on Platelet Volume in Children

Akça¹,

Ürel²,

Karacan³

et al. 2017

cayd

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GirişKarbonmonoksit (CO), karbon içeren maddelerin tam yanmaması sonucu oluşan, renksiz, kokusuz, tatsız, irritan olmayan ve toksik bir gazdır. Özellikle kış aylarında sıklığı artan CO zehirlenmeleri, ülkemizde ve dünyada önemli bir toplum sağlığı sorunudur. Çocukluk çağında görülen zehirlenmeler arasında CO zehirlenmesi genellikle ilk üç sırada yer alır.1 CO zehirlenmesi önemli bir morbidite ve mortalite nedenidir. Birçok organ sistemi tutulabilir ve fark edilmeyen maruziyetler ölümle sonuçlanabilir. Ülkemizde ölümle sonuçlanan zehirlenmelerin en sık nedeni olarak bildirilmiştir. Bulgular: Çalışmaya alınan 228 hastanın (%49 erkek) ortalama yaşı 88±56 aydı. Kontrol grubu için benzer yaş aralığında olan 200 sağlıklı çocuk seçildi. MPV değeri çalışma grubunda 8,43±1,1 fL, kontrol grubunda 8,26±0,7 fL idi, arada anlamlı istatistiksel fark bulunamadı. Karboksihemoglobin (COHb) değeri ile MPV değeri ve trombosit sayısı arasında da korelasyon saptanmadı. Sonuç: Çalışmamızda çocukluk çağında MPV değerinin akut karbonmonoksit zehirlenmesi tanısını öngörmede yardımcı bir parametre olmadığı saptanmıştır. Hastaların MPV değerlerinin bulgulara göre karşılaştırıldığında anlamlı fark bulunmaması ve MPV değeri ile COHb seviyesi arasında korelasyon saptanmamış olması nedeniyle, MPV'nin hastalığın klinik şiddeti hakkında yol gösterici olmadığı sonucuna varılmıştır. Anahtar Kelimeler: Çocuk, karbonmonoksit zehirlenmesi, ortalama trombosit hacmi Introduction: Carbon monoxide poisoning is one of the most important causes of morbidity and mortality. There is increasing evidence supporting the important role of mean platelet volume (MPV) as a marker of hypoxia and inflammation. In this study, we aimed to determine changes in MPV values in pediatric patients with carbon monoxide poisoning. Methods: We retrospectively evaluated children who were diagnosed with carbon monoxide poisoning in our hospital between January 2005 and 2014. Results: We included 228 children with carbon monoxide poisoning (49% male) in this retrospective, controlled study. The mean age of the patients was 88±56 months. Control group consisted of 200 age-matched healthy children. There was no statistically significant difference in MPV levels between the study and control groups (8.43±1.1 fL and 8.26±0.7 fL, respectively). No correlation of MPV and platelet count with carboxyhemoglobin (COHb) was found. Conclusion: In our study, it was determined that MPV value was not a helpful parameter for predicting the diagnosis of acute carbon monoxide poisoning in childhood. The difference between the MPV values and the lack of significance and the absence of correlation between MPV value and COHb level led to the fact that MPV was not a guide indicating the clinical severity of the condition.

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Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

Cited by 21 publications

References 33 publications

The mean platelet volume is decreased in patients with mild head trauma and brain injury

The mean platelet volume is decreased in patients with mild head trauma and brain injury

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

The Effect of Carbon Monoxide Poisoning on Platelet Volume in Children

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