Increased preoperative serum C‐reactive protein level predicts a poor prognosis in patients with localized renal cell carcinoma

Komai, Yoshinobu; Saito, Kazutaka; Sakai, Kunihiko; Morimoto, Shinji

doi:10.1111/j.1464-410x.2006.06497.x

Cited by 98 publications

(71 citation statements)

References 20 publications

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“…Moreover, the extent of elevation of CRP levels in these diseases was also greater than that in other diseases. It has been reported that elevated CRP concentrations are also commonly observed in patients with neoplastic [10] and immune-mediated diseases in human medicine [7,9]. However, we have to consider that the frequency of the diseases studied was biased since this study was conducted at a teaching hospital in a university.…”

Section: Discussionmentioning

confidence: 99%

“…Measuring the CRP concentration along with WBC counts is clinically valuable as a screening test for new patients to detect inflammation. In human medicine, CRP has been reported to indicate the severity and prognosis of various diseases [9,10,16,17]. In veterinary medicine, it has been reported to indicate the response to treatment and prognosis in idiopathic polyarthritis [14].…”

Section: Discussionmentioning

confidence: 99%

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C-Reactive Protein Concentration in Dogs with Various Diseases

et al. 2008

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ABSTRACT. To investigate the clinical utility of C-reactive protein (CRP) determination in dogs, its plasma concentration was measured by a laser nephelometric method in 928 dogs with various diseases, and was compared with other inflammatory parameters. CRP concentration was elevated in various inflammatory diseases, this was most frequently observed in cases with neoplastic and immune-mediated diseases. All cases of pyometra, panniculitis, acute pancreatitis, polyarthritis, and hemangiosarcoma showed significantly elevated CRP concentrations. On the other hand, the CRP concentration was elevated only in few cases of neurological diseases such as epilepsy, meningoencephalitis, and hydrocephalus and endocrine diseases such as hypothyroidism, hyperadrenocorticism, and diabetes mellitus. Only a weak correlation was observed between the CRP concentration and white blood cell (WBC) counts (r=0.44) but no correlation with band neutrophil counts. There was no correlation between the CRP and albumin concentrations, but a weak negative correlation (r=-0.40) when excluding chronic intestinal diseases and nephrotic syndrome, which can cause protein loss. Thus, CRP can be useful to detect inflammations that cannot be detected by WBC and, or band neutrophil counts, suggesting that the examination of CRP concentration is essential as routine diagnostic test. KEY WORDS: albumin, C-reactive protein (CRP), canine, neutrophil, WBC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein Concentration in Dogs with Various Diseases

et al. 2008

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“…The 5-year RFS and CSS rates in patients with elevated CRP levels were 55.8 and 75.4%, respectively, compared with 93.1 and 94.8%, respectively, in patients without CRP elevation (P < 0.0001). 42 Lambs et al observed that elevation of CRP levels (>10 mg/L) was linked to poorer CSS in 100 RCC patients without metastasis. 41 Thereafter, they showed the significance of CRP elevation (>10 mg/L) to predict poorer RFS and CSS in a prospective study with 83 RCC patients undergoing curative nephrectomy.…”

Section: Prognostic Value Of Crp In Renal Cell Carcinomamentioning

confidence: 99%

Role of C‐reactive protein in urological cancers: A useful biomarker for predicting outcomes

Saito

Kihara

2012

Int J of Urology

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Abbreviations & AcronymsAbstract: Based on increasing evidence of the association between cancer-related inflammation and the progression of cancer, the external symptoms of systemic inflammatory response has been shown to be an indicator for the prognosis of many malignancies, including urological cancers. C-reactive protein, a representative acute-phase reactant, is a significant and sensitive inflammatory marker that can be objectively measured using reliable assays in clinical practice worldwide. C-reactive protein has been shown to be significant in the prediction of outcomes of urological cancers. The elevation of C-reactive protein levels, which indicate the presence of cancer-associated systemic inflammatory response, is linked to poorer survival in patients with urological cancers, including renal cell carcinoma, upper urinary tract and bladder cancers, and prostate cancer. With this strong prognostic ability, C-reactive protein can be incorporated into prognostic models and will make them simpler and improve their predictive accuracy. Furthermore, the longitudinal change of C-reactive protein level, C-reactive protein kinetics, provides additional information on patient survival outcomes. As such, C-reactive protein can be used to monitor treatment efficacy and disease course using serial measurements. In testicular cancer, C-reactive protein is associated with a risk of late complications, such as cardiovascular disease, and with the development of second non-germ-cell cancer. Taken together, these findings show that C-reactive protein can act as an important biomarker for urological cancers. This review discusses the importance of C-reactive protein as a prognostic biomarker in urological cancers on the basis of the currently available evidence.

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“…Smaller studies published in recent years which included from 40 up to 313 patients indicated that the preoperative CRP level could also be associated with RCC-specific mortality [19][20][21][22][23][24][25][26]. These smaller trials have shown a potential relationship between circulating CRP levels and tumour stage as well as a significant impact on the prognosis of patients with RCC.…”

Section: Introductionmentioning

confidence: 99%