Increased prevalence of antithyroid antibodies identified in women with recurrent pregnancy loss but not in women undergoing assisted reproduction

Kutteh, William H.; Yetman, Deborah L.; Carr, Alexander C; Beck, Leslie A; Scott, Richard T.

doi:10.1016/s0015-0282(99)00091-6

Cited by 164 publications

(114 citation statements)

References 18 publications

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“…Four studies were excluded because TAI status had not been determined (24)(25)(26) or women with TAI had been excluded (27). Three studies were excluded because women with recurrent spontaneous miscarriages had been recruited (28)(29)(30) and another three studies because the IVF outcome had not been recorded or presented (14,31,32).…”

Section: Search Resultsmentioning

confidence: 99%

“…Currently, it is not clear whether there is an association between TAI and poor IVF outcome (5,7). Several studies which examined the association between TAI status and miscarriage provided rather controversial results (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), although it appears that 'TAI per se does not alter the implantation of embryo' (19). Moreover, observations regarding TAI and miscarriage risk from the general population could not be applied to an IVF setting and vice versa, since women undergoing IVF are considered as a distinct subgroup, representing a 'special population' (20).…”

Section: Introductionmentioning

confidence: 99%

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Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis

Toulis¹,

Goulis²,

Venetis³

et al. 2010

European Journal of Endocrinology

146

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Objective: To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF. Design: Meta-analysis of observational studies. Patient(s): Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis. Main outcome measure: Miscarriage risk ratio (RR). Secondary outcome measures: Clinical pregnancy rate and delivery rate. Result(s): Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42-2.79, P!0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups. Conclusion: Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.

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Section: Search Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis

Toulis¹,

Goulis²,

Venetis³

et al. 2010

European Journal of Endocrinology

146

View full text Add to dashboard Cite

show abstract

“…The studies differed in various aspects. Some had followed a cohort (235)(236)(237)248,250,252,253,(260)(261)(262)(263)(264)(265)(266)(267)(268)(269)(270)(271) (B,A,B,B,B,B,B,A,B-B) and others were "case-controlled" studies (251,254,(272)(273)(274)(275) (C,C,C,C,C).…”

Section: What Is the Role Of Thyroid Autoimmunity In Fertility And Prmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

125

123

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Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

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“…anti-thyroperoxidase (TPO) or antithyroglobulin (Tg) antibodies. TAI is present in up to 15% of women of reproductive age (2) and is thus more frequent than thyroid dysfunction. Both AITD and TAI have been associated with adverse pregnancy outcomes (3), but the relevance of TAI in particular is not yet understood.…”

Section: Introductionmentioning

confidence: 99%

Thyroid autoantibodies per se do not impair intracytoplasmic sperm injection outcome in euthyroid healthy women

Tan

Dieterle

Pechlavanis

et al. 2014

European Journal of Endocrinology

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Objective: Autoimmune thyroid disease (AITD) has been associated with adverse pregnancy outcomes in subfertile women with spontaneous and assisted reproductive technology-induced pregnancies. The underlying pathophysiology is still elusive and an association with thyroid dysfunction or other infertility causes is discussed. However, whether thyroid autoimmunity (TAI) per se has a negative impact on female fertility has not yet been clarified. In this study, we investigated whether TAI in healthy women undergoing intracytoplasmic sperm injection (ICSI) for male infertility may affect pregnancy outcome. Design: A retrospective, single-centre study. Methods: The ICSI outcome data obtained from 835 euthyroid women (age: 31.4G4.3 years, BMI: 23.7G4.2 kg/m 2 ) were correlated with pre-ICSI TAI status. The known causes of female subfertility were excluded. Outcome parameters included rates of pregnancy, birth, miscarriage and preterm delivery. Blood analysis was carried out retrospectively using blood samples drawn before ICSI. TAI was defined by elevation of anti-thyroperoxidase-or anti-thyroglobulin-antibodies O100 U/l. Results: TAI-positive and -negative groups did not differ in age, BMI or TSH levels. TAI status did not influence any ICSI outcome parameters. In contrast, increasing maternal age was significantly correlated with lower pregnancy rate (odds ratio (OR): 0.94 (95% CI: 0.91-0.97); PZ0.0003) and birth rate (OR: 0.93 (95% CI: 0.09-0.97); P!0.0001). Conclusions: Our study suggests that TAI per se does not influence ICSI outcome. A strict definition of AITD and TAI and consideration of TAI-associated and -independent confounders are important to further elucidate the interplay between TAI and reproduction.

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Increased prevalence of antithyroid antibodies identified in women with recurrent pregnancy loss but not in women undergoing assisted reproduction

Cited by 164 publications

References 18 publications

Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis

Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis

Clinical practice guidelines for the management of hypothyroidism

Thyroid autoantibodies per se do not impair intracytoplasmic sperm injection outcome in euthyroid healthy women

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