Increased Prevalence of Factor V G1,691A (Leiden) Mutation in Neonates with Intracranial Hemorrhage 71

Melegh, Béla; Stankovics, J.; Kis, Andrea; Storcz, Judit; Nagy, Ágnes; Losonczy, Hajna; Méhes, K

doi:10.1203/00006450-199709000-00091

Cited by 11 publications

(17 citation statements)

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“…This result shows an impact of the factor V Leiden mutation in the development of grade I IVH in premature infants and this observation is in accordance with our previous fi ndings [19] . In a previous preliminary work, 60 infants with IVH were studied of whom 27 were premature.…”

Section: Discussionsupporting

confidence: 82%

“…In a previous preliminary work, 60 infants with IVH were studied of whom 27 were premature. We found 9 (15% of total) heterozygote newborns, 8 of whom (29.6% of total) were prematures, while the heterozygosity rate in controls was 6.4% [19] . The results of the present study confi rm and further specify the previous fi ndings in a larger and in genetic context partially selected population.…”

Section: Discussionmentioning

confidence: 96%

“…Protein C resistance develops which results in a decreased fi brinolysis and consequently shifts the balance towards an increased coagulation in vitro [12,18] . Our preliminary observation showed increased prevalence of factor V Leiden in grade I intracranial haemorrhage (IVH) [19] . In another populationbased cohort study on 305 infants, Gopel et al [9] found a signifi cantly reduced risk of developing extension of IVH to grade II or more in premature neonates (birth weight ^ 1,500 g) with factor V Leiden and prothrombin G20210A mutations.…”

Section: Introductionmentioning

confidence: 99%

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Increased Prevalence of Factor V Leiden Mutation in Premature but Not in Full-Term Infants with Grade I Intracranial Haemorrhage

Komlósi

Havasi²,

Bene³

et al. 2005

Neonatology

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Objectives: In the current prospective study our aim was to analyse the distribution of the factor V Leiden (G1691A) mutation in preterm and full-term neonates with grade I intraventricular haemorrhage and in control neonates. Study Method: A group of 125 individually selected neonates with grade I intraventricular haemorrhage and 128 controls were investigated. Results: The allele frequency was 7.2% in the total population of affected infants while it was 3.9% in the controls (p < 0.05); the latter corresponds to an average European allele frequency in healthy populations. When the infants were grouped as premature (<2,500 g and ≤36 weeks of gestational age) and appropriate for gestational age full-term infants the statistical analysis revealed an increased prevalence of the mutation in the premature group (10% allele frequency vs. 4.8% in the controls, p < 0.05), and a normal prevalence in the mature group (4.6 vs. 3.1%, respectively); therefore, the overall increase was due to the increase of incidence rate in preterm neonates. Conclusions: These data confirm our previous results and suggest that as the preterm and term infants differ from each other in haemorrhage susceptibility in many clinical particulars, carrying of the mutation has probably also a different impact in premature and in full-term infants with respect to the intraventricular haemorrhage.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Increased Prevalence of Factor V Leiden Mutation in Premature but Not in Full-Term Infants with Grade I Intracranial Haemorrhage

Komlósi

Havasi²,

Bene³

et al. 2005

Neonatology

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“…The prevalence of the mutation in an apparently healthy Hungarian Caucasian population sample of our region was 6.33% [5], which was comparable with other European prevalence rates [6]. The results of our present study are shown in table 1.…”

Section: Resultssupporting

confidence: 77%

High Prevalence of Factor V Leiden Mutation in Mothers of Premature Neonates

Erhardt

Stankovics²,

Molnár³

et al. 2000

Neonatology

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The prevalence of the Leiden mutation was tested in 50 mothers of premature infants and in 56 mothers of intrauterine-growth-retarded neonates. The prevalence of the Leiden mutation was 7.2% in the mothers of growth-retarded neonates and 18% in the group of mothers of premature infants, the latter being significantly higher than the 6.3% prevalence of this mutation in healthy Hungarian subjects (p < 0.01). In spite of the relatively small number of mothers examined, the unexpected finding may call attention to a hitherto unknown relationship.

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“…9 A possible direct role of thrombophilia in triggering GMH-IVH is reinforced by the evidence of the venous origin of this form of intracranial bleeding, 10,11 because thrombophilia increases the risk of venous thrombosis in the small venules of germinal matrix. Accordingly, factor V Leiden and prothrombin mutations seem to increase the risk of GMH-IVH developing in preterm infants, 12,13 although the methodology and the statistical evidence of these observations deserve further studies. 1 However, these mutations were not found to be associated with an increased risk of IVH in a Israeli population of 166 premature infants, 14 and other authors even suggest a protective role for thrombophilia versus the severest forms of GMH-IVH.…”

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confidence: 99%

Germinal Matrix Hemorrhage: Intraventricular Hemorrhage in Very-Low-Birth-Weight Infants

Ramenghi

Fumagalli

Groppo

et al. 2011

Stroke

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Background and Purpose-The etiology of germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is multifactorial and the role of genetic polymorphisms is unclear. The aim of this prospective study was to evaluate prothrombotic genetic mutations as independent risk factors for the development of all grades of GMH-IVH in very-low-birth-weight infants. Methods-The presence of both factor V Leiden and prothrombin gain-of-function gene mutations were prospectively assessed in 106 very-low-birth-weight infants.

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Increased Prevalence of Factor V G1,691A (Leiden) Mutation in Neonates with Intracranial Hemorrhage 71

Cited by 11 publications

References 0 publications

Increased Prevalence of Factor V Leiden Mutation in Premature but Not in Full-Term Infants with Grade I Intracranial Haemorrhage

Increased Prevalence of Factor V Leiden Mutation in Premature but Not in Full-Term Infants with Grade I Intracranial Haemorrhage

High Prevalence of Factor V Leiden Mutation in Mothers of Premature Neonates

Germinal Matrix Hemorrhage: Intraventricular Hemorrhage in Very-Low-Birth-Weight Infants

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