Increased Prevalence of G1P[4] Genotype among Children with Rotavirus-Associated Gastroenteritis in Metropolitan Detroit

Abdel‐Haq, Nahed; Thomas, Robert A.; Asmar, Basim I.; Zacharova, Viera; Lyman, William D.

doi:10.1128/jcm.41.6.2680-2682.2003

Cited by 30 publications

(24 citation statements)

References 18 publications

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“…In our study, we detected many strains showing the "uncommon" G/P combination G1P [4], G2P [4], or G4P [4], the latter with a particularly high rate in Albania (13.3% of all cases [ Table 3]). These data further suggest that reassortment between common strains of rotavirus may occur easily in nature, as also has been documented in previous surveillance studies (1,18,26,36). The peak incidence for G9 and G8 strains was observed in infants less than 1 year old, whereas the peak incidence for all rotavirus infection, including common G1 to G4 strains, was observed for the age group 2 to 3 years.…”

Section: Discussionsupporting

confidence: 60%

“…Among the VP4 genotypes, P [8] occurred most frequently (up to 80%) in all countries, followed by P [4] (up to 35%). P [1], P [6], and P [11] were rarely identified in Croatia and Slovenia.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, these results suggest the circulation of viruses with unusual G and/or P genotypes which are not detected by the sets of primers normally adopted in genotyping protocols designed for human strains. Some of the untyped strains may indeed be strains of animal origin, such as G5, G6, P [1], P [5], and P [7], which we have not specifically searched for, or human strains mutated at the genotype-specific primer binding site through genetic drift.…”

Section: Discussionmentioning

confidence: 99%

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Molecular Epidemiology of Rotavirus in Central and Southeastern Europe

Tcheremenskaia¹,

Marucci²,

Petris³

et al. 2007

J Clin Microbiol

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Section: Discussionsupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Molecular Epidemiology of Rotavirus in Central and Southeastern Europe

Tcheremenskaia¹,

Marucci²,

Petris³

et al. 2007

J Clin Microbiol

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“…The percentages of such unusual strains were much higher in Africa (27%), Asia (14%) and South America (11%) than in North America, Europe and Australia (5%, 1.4% and 0.1%, respectively). Rotavirus strains carrying P [4]G1 [27,36,37], P [8]G2 [36,38,39], P [4]G3 [27,[40][41][42], P [9]G4 [42], P [4]G4 [37,43], P[4]G9 [22,44], P [10]G9 [44], P [6]G12 [45,46] or P [9]G12 [47] specificity may represent naturally occurring reassortants among various human rotavirus genotypes [43]. On the other hand, unusual strains such as P [11]G3 [48], P[1]G4 [49], P [11]G4 [50], P [6]G5 [39], P [8]G5 [51], P[6]G6 [52], P [9]G6 [19,53,54], P [14]G6 [53][54][55][56], P …”

Section: Global Distribution Of Human Rotavirus G and P Combinations mentioning

confidence: 99%

Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine

Santos

Hoshino

2004

Reviews in Medical Virology

1,145

1,230

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A safe and effective rotavirus vaccine is urgently needed, particularly in developing countries. Critical to vaccine development and implementation is a knowledge base concerning the epidemiology of rotavirus G and P serotypes/genotypes throughout the world. The temporal and geographical distribution of human rotavirus G and P types was reviewed by analysing a total of 45571 strains collected globally from 124 studies reported from 52 countries on five continents published between 1989 and 2004. Four common G types (G1, G2, G3 and G4) in conjunction with P[8] or P[4] represented over 88% of the strains analysed worldwide. In addition, serotype G9 viruses associated with P[8] or P[6] were shown to have emerged as the fourth globally important G type with the relative frequency of 4.1%. When the global G and/or P type distributions were divided into five continents/subcontinents, several characteristic features emerged. For example, the P[8]G1 represented over 70% of rotavirus infections in North America, Europe and Australia, but only about 30% of the infections in South America and Asia, and 23% in Africa. In addition, in Africa (i) the relative frequency of G8 was as high as that of the globally common G3 or G4, (ii) P[6] represented almost one-third of all P types identified and (iii) 27% of the infections were associated with rotavirus strains bearing unusual combinations such as P[6]G8 or P[4]G8. Furthermore, in South America, uncommon G5 virus appeared to increase its epidemiological importance among children with diarrhea. Such findings have (i) confirmed the importance of continued active rotavirus strain surveillance in a variety of geographical settings and (ii) provided important considerations for the development and implementation of an effective rotavirus vaccine (e.g. a geographical P-G type adjustment in the formulation of next generation multivalent vaccines).

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“…The importance of rotavirus as one of the main causes of acute gastroenteritis in infants and young children is evident [1,2,17,18]. Rotavirus has been continuously present in different European studies over the last two decades [9,20,31] as a consequence of the implementation of virological diagnostic methods [5,24] and its considerable burden of disease [7,19].…”

Section: Introductionmentioning

confidence: 99%

Gastroenteritis by rotavirus in Spanish children. Analysis of the disease burden

et al. 2007

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Rotavirus is one of the most common causes of gastroenteritis worldwide. With the commercialisation of effective rotavirus vaccines in Europe in sight, it is necessary to provide studies which evaluate the disease burden. The aim of this study is two-fold, on one hand, to determine the burden of the rotavirus disease in Spanish children under the age of five, and on the other, to estimate the economic cost of these hospitalizations. The study was undertaken during a 5 year period (2000-2004). The rotavirus hospitalization rate was determined using the Minimum Basic Data Set of the national hospital discharge register. The observed data were compared with those expected by applying a model developed by the Centers for Disease Control and Prevention (CDC) adapted for European Countries. The financial expense of these hospitalizations was estimated. Of all admissions coded as gastroenteritis, 31.6% were due to rotavirus. The hospitalization rate by rotavirus was 480 cases per 100,000 children under five. These data are within the confidence range proposed by the adapted CDC model. The financial expense due to hospitalizations reaches 123,262 euros yearly in a Spanish University Hospital. In conclusion, rotavirus contributes significantly to the hospitalization of acute gastroenteritis. The rate of hospitalization by rotavirus is higher compared to other studies carried out in Spain. In view of future commercialisation of rotavirus vaccines, more in-depth analysis considering direct and indirect costs are necessary.

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Increased Prevalence of G1P[4] Genotype among Children with Rotavirus-Associated Gastroenteritis in Metropolitan Detroit

Cited by 30 publications

References 18 publications

Molecular Epidemiology of Rotavirus in Central and Southeastern Europe

Molecular Epidemiology of Rotavirus in Central and Southeastern Europe

Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine

Gastroenteritis by rotavirus in Spanish children. Analysis of the disease burden

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