Increased Prevalence of Gastroesophageal Reflux Disease Among Patients
With Rheumatoid Arthritis: A Systematic Review and Meta-analysis

Thongpiya, Jerapas; Charoenngam, Nipith; Ponvilawan, Ben; Yingchoncharoen, Pitchaporn; Jaroenlapnopparat, Aunchalee; Ungprasert, Patompong

doi:10.2174/1573397119666230414103624

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…Coincidentally, the HR (1.49) of RA in patients with GERD calculated by one cohort study was approximate to our UVMR result, but the HR (1.46) of GERD in patients with RA is not found in our study ( Kim et al, 2021 ). Recently, a meta-analysis research based on cohort studies has also reported an OR of 1.98 for GERD in patients with RA ( Thongpiya et al, 2023 ). It is important to note that the observational studies utilized in the meta-analysis were predominantly conducted on the Asian population, whereas our MR analysis is based on the European population.…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis and gastroesophageal reflux disease: a bidirectional and multivariable two-sample Mendelian randomization study

Wang,

Chen,

Dang

et al. 2023

Front. Genet.

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Aims/hypothesis: The association between gastroesophageal reflux disease (GERD) and rheumatoid arthritis (RA) has been reported by many observational studies in the Asian population. This study aimed to examine the bidirectional causal effects between GERD and RA by two-sample Mendelian randomization (MR) analyses using genetic evidence.Methods: Two-sample Mendelian randomization analyses were performed to determine the causal effect of GERD (129,080 cases vs. 602,604 control participants) on RA (6,236 cases vs. 147,221 control participants) and RA on GERD, respectively. The inverse-variance weighted (IVW) method was used as the primary analysis. Weighted median and MR-Egger regression were taken as supplementary analyses. Cochran’s Q test evaluated the heterogeneity. Horizontal pleiotropy was detected by estimating the intercept term of MR-Egger regression. Furthermore, multivariable MR analyses were performed to exclude the influence of confounding factors, including the years of schooling, BMI, and time spent watching television, between GERD and RA.Result: Both univariate MR (UVMR) and multivariable MR (MVMR) provided valid evidence that RA was causally and positively influenced by GERD (UVMR: OR = 1.49, 95% CI = 1.25–1.76, p = 6.18*10−6; MVMR: OR = 1.69, 95% CI = 1.24–2.31, p = 8.62*10−4), whereas GERD was not influenced by RA (UVMR: OR = 1.03, 95% CI = 1.00–1.06, p = 0.042; MVMR: OR = 1.04, 95% CI = 1.00–1.07, p = 0.0271).Conclusion: Our comprehensive bidirectional MR analysis found that for the European population, GERD can induce the occurrence of RA (OR = 1.69, p < 0.00125), whereas RA only has no significant influence on GERD. In particular, patients with GERD are suffering a 69% increased risk of RA occurrence, which means GERD is a substantial risk factor for RA.

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Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis and gastroesophageal reflux disease: a bidirectional and multivariable two-sample Mendelian randomization study

Wang,

Chen,

Dang

et al. 2023

Front. Genet.

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“…(2) Italian pizza is easier to digest, because high-quality tomato sauce is generally used [77], and the pizza is cooked at scorching temperatures [78]. This is a point in favor of pizza consumption in RA patients, who show an increased prevalence of gastro-esophageal reflux [79]. (3) In Italian pizza, not only does the emulsion of oil with tomato sauce before the cooking phase contribute to the uniform cooking of the ingredients [28], but it generally enhances the pizza's antioxidant potential, including the content of phenolic compounds and lycopene, the Trolox Equivalent Antioxidant Capacity, and the bio-accessibility of phenolic compounds and lycopene [77].…”

Section: Discussionmentioning

confidence: 99%

Does Pizza Consumption Favor an Improved Disease Activity in Rheumatoid Arthritis?

et al. 2023

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To our knowledge, no studies so far have investigated the role of pizza and its ingredients in modulating disease activity in rheumatoid arthritis (RA). We assessed this question via a recent cross-sectional study including 365 participants from Italy, the birthplace of pizza. Multiple robust linear and logistic regression models were fitted with the tertile consumption categories of each available pizza-related food item/group (i.e., pizza, refined grains, mozzarella cheese, and olive oil) as independent variables, and each available RA activity measure (i.e., the Disease Activity Score on 28 joints with C-reactive protein (DAS28-CRP), and the Simplified Disease Activity Index (SDAI)) as the dependent variable. Stratified analyses were carried out according to the disease severity or duration. Participants eating half a pizza >1 time/week (vs. ≤2 times/month) reported beneficial effects on disease activity, with the significant reductions of ~70% (overall analysis), and 80% (the more severe stratum), and the significant beta coefficients of −0.70 for the DAS28-CRP, and −3.6 for the SDAI (overall analysis) and of −1.10 and −5.30 (in long-standing and more severe RA, respectively). Among the pizza-related food items/groups, mozzarella cheese and olive oil showed beneficial effects, especially in the more severe stratum. Future cohort studies are needed to confirm this beneficial effect of pizza and related food items/groups on RA disease activity.

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Autoimmune dysphagia

Tai,

Suppiah

2024

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review Dysphagia is a complication of several autoimmune rheumatic diseases and otorhinolaryngologists are likely to be involved in the assessment and management of patients with such conditions. This review provides an update on rheumatic diseases that may cause swallowing impairment, with particular focus on the epidemiology, pathophysiology and management of dysphagia in these conditions. Recent findings Dysphagia is a common complication of the following rheumatic diseases: idiopathic inflammatory myopathies, systemic sclerosis, Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis. It may also be a complication of rarer autoimmune conditions such as Bechet's syndrome, sarcoidosis and granulomatosis with polyangiitis. All three stages of swallowing (oral, pharyngeal and oesophageal) may be impaired in these conditions. Both medical therapy and surgical intervention play an important role in the management of autoimmune dysphagia. Summary The investigation and management of autoimmune dysphagia requires close collaboration between rheumatologists and otorhinolaryngologists. There is a need for further research to establish standardised guidelines on the assessment and management of autoimmune dysphagia.

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Increased Prevalence of Gastroesophageal Reflux Disease Among Patients With Rheumatoid Arthritis: A Systematic Review and Meta-analysis

Cited by 4 publications

References 46 publications

Rheumatoid arthritis and gastroesophageal reflux disease: a bidirectional and multivariable two-sample Mendelian randomization study

Rheumatoid arthritis and gastroesophageal reflux disease: a bidirectional and multivariable two-sample Mendelian randomization study

Does Pizza Consumption Favor an Improved Disease Activity in Rheumatoid Arthritis?

Autoimmune dysphagia

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