Increased Prevalence of Gastroesophageal Reflux Symptoms in Obese Children Evaluated in an Academic Medical Center

Pashankar, Dinesh S.; Corbin, Zachary; Shah, Syed Kashif Ali; Caprio, Sonia

doi:10.1097/mcg.0b013e3181705ce9

Cited by 52 publications

(43 citation statements)

References 19 publications

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“…Thus, it is possible that some of the associations reported herein are due to ‘tracking' (correlation) of adiposity from childhood through early and mid-adulthood. Alternatively, associations of childhood obesity with gastroesophageal reflux disease (Malaty et al , 2009; Pashankar et al , 2009; Ruigomez et al , 2010; Koebnick et al , 2011) and metabolic disorders may directly affect future risks of EA and GCA (Adegboye et al , 2010; Abrams and Levitt Katz, 2011). …”

Section: Discussionmentioning

confidence: 99%

Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies

et al. 2017

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Background:Elevated body mass index (BMI, kg m−2) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored.Methods:We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA). At baseline, participants reported their height and weight at ages 20 and 50 years, and current. Body mass index trajectories were determined using latent class analysis. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression.Results:Compared with individuals with a BMI<25 kg m−2 at all time points, exceeding a BMI of 25 kg m−2 at age 20 was associated with increased risks of EA (HR=1.76, 95% CI: 1.35–2.29) and GCA (HR=1.62, 95% CI: 1.16–2.25). Similarly, a BMI trajectory of overweight (⩾25–<30 kg m−2) at age 20 progressing to obesity (⩾30 kg m−2) by age 50 was associated with increased risks of EA (HR=2.90, 95% CI: 1.67–5.04) and GCA (HR=4.07, 95% CI: 2.32–7.15), compared with individuals with a normal weight (⩾18.5–<25 kg m−2) trajectory. Weight gain of ⩾20 kg between age 20 and baseline was also associated with a two times increased risk of EA (HR=1.97, 95% CI: 1.43–2.73) and more modestly with GCA (HR=1.40, 95% CI: 0.96–2.05).Conclusions:Being overweight in early adulthood and weight gain later in life were each associated with increased risks of EA and GCA. This underscores the potential of weight control programs for reducing EA and GCA risk.

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Section: Discussionmentioning

confidence: 99%

Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies

et al. 2017

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“…In adults higher body mass index (BMI) (12–14) and abdominal obesity (15) have been shown to increase the risk of developing GERD; however, data on this association in children are scarce and inconclusive. Of the three pediatric studies (16–18), two (16,17) showed a positive and one (18) no association between pediatric obesity with GERD. However, two of these studies were hospital‐based (16,18), and one included mainly asthma patients (17).…”

Section: Introductionmentioning

confidence: 93%

Extreme childhood obesity is associated with increased risk for gastroesophageal reflux disease in a large population-based study

Koebnick

Getahun

Smith

et al. 2011

International Journal of Pediatric Obesity

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“…A 13% prevalence of gastroesophageal reflux has been observed in obese children (Pashankar, Corbin, Shah, & Caprio, 2009). NAFLD has been shown to occur in 2.6–25% of obese children and adolescents from small epidemiological studies using indirect diagnosis tests such as liver enzymes or ultrasound (Socha et al, 2009), while an autopsy study reported a 9.6% prevalence in children ages 2–19 years and a higher prevalence among obese children (38%) (Schwimmer, Deutsch et al, 2003).…”

Section: Consequences Of Pediatric Obesitymentioning

confidence: 99%

Pediatric obesity. An introduction

Yanovski

2015

Appetite

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The prevalence of child and adolescent obesity in the United States increased dramatically between 1970 and 2000, and there are few indications that the rates of childhood obesity are decreasing. Obesity is associated with myriad medical, psychological, and neurocognitive abnormalities that impact children’s health and quality of life. Genotypic variation is important in determining the susceptibility of individual children to undue gains in adiposity; however, the rapid increase in pediatric obesity prevalence suggests that changes to children’s environments and/or to their learned behaviors may dramatically affect body weight regulation. This paper presents an overview of the epidemiology, consequences, and etiopathogenesis of pediatric obesity, serving as a general introduction to the subsequent papers in this Special Issue that address aspects of childhood obesity and cognition in detail.

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Increased Prevalence of Gastroesophageal Reflux Symptoms in Obese Children Evaluated in an Academic Medical Center

Abstract: Obese children (age: 7 to 16 y) are at higher risk of having reflux symptoms compared with the control group. This risk is independent of age, sex, or race and increases with higher BMI.

Cited by 52 publications

References 19 publications

Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies

Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies

Extreme childhood obesity is associated with increased risk for gastroesophageal reflux disease in a large population-based study

Pediatric obesity. An introduction

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