Increased Prevalence of Irritable Bowel Syndrome in Patients With Gastroesophageal Reflux

Pimentel, Mark; Rossi, F; Chow, Elaine; Ofman, Joshua J.; Fullerton, S; Hassard, Phillip; Lin, Henry C.

doi:10.1097/00004836-200203000-00004

Cited by 58 publications

(61 citation statements)

References 23 publications

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“…39 The high prevalence of IBS in GERD patients in this study corroborates previous reports of this association. 2,25,26 However, two of these were small-scale studies comprising 22 and 35 patients each. 25,26 Hitherto, a possible role for IBS features in GERD symptoms has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…2,25,26 However, two of these were small-scale studies comprising 22 and 35 patients each. 25,26 Hitherto, a possible role for IBS features in GERD symptoms has not been reported. Such a role is plausible in as much as visceral hypersensitivity, a biological marker of IBS, 24 has been reported in GERD patients and incriminated in some of the extra-oesophageal manifestations of this disorder.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 This latter feature is considered a biological marker of the irritable bowel syndrome (IBS), 24 a condition associated with GERD. 2,25,26 In as much as the basic pathophysiological mechanism in GERD is exposure of the oesophageal mucosa to the noxious effect of acid, and since acid exposure accounts for only a minor fraction of the variation in GERD symptoms, the relationship between OAE and GERD symptoms might be modulated by additional factors were hypothesized. Two possible such factors are smoking and visceral hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Irritable bowel, smoking and oesophageal acid exposure: an insight into the nature of symptoms of gastro‐oesophageal reflux

Zimmerman¹

2004

Aliment Pharmacol Ther

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Summary Background : In gastro‐oesophageal reflux disease, oesophageal acid exposure correlates with symptoms but explains only a small fraction of their variance. Aims : To elucidate the effects of irritable bowel syndrome and smoking on gastro‐oesophageal reflux disease symptoms and to clarify whether they modulate the relationship between oesophageal acid exposure and symptoms. Methods : The relationship between oesophageal acid exposure, irritable bowel syndrome (Rome I criteria), smoking status and symptoms was investigated in patients with a normal gastroscopy who underwent a 24‐h oesophageal pH monitoring. Results : Of 256 patients with gastro‐oesophageal reflux disease, 16% were smokers and 50% met the criteria for irritable bowel syndrome (irritable bowel syndrome+). The extent of oesophageal acid exposure was unrelated to smoking or irritable bowel syndrome status. Oesophageal acid exposure, irritable bowel syndrome status and current smoking independently predicted symptoms. Irritable bowel syndrome and smoking modulated the effect of oesophageal acid exposure on symptoms: oesophageal acid exposure was predictive of symptoms only in non‐smokers. However, irritable bowel syndrome was a significant predictor of symptoms both in smokers and in non‐smokers. Smoking was associated with symptoms only in irritable bowel syndrome+, while oesophageal acid exposure was associated with symptoms irrespective of irritable bowel syndrome status. Conclusions : In patients with non‐erosive gastro‐oesophageal reflux disease, smoking and irritable bowel syndrome independently predicted symptoms, without affecting the extent of oesophageal acid exposure. The relationship between oesophageal acid exposure and symptoms was affected significantly, and in opposite directions, by smoking and irritable bowel syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Irritable bowel, smoking and oesophageal acid exposure: an insight into the nature of symptoms of gastro‐oesophageal reflux

Zimmerman¹

2004

Aliment Pharmacol Ther

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“…In the present study, half of the NERD, EE and dyspepsia patients met the diagnosis of IBS as defined by the Rome I criteria. Pimentel et al (Pimentel et al 2002) have reported a higher prevalence of IBS in subjects with GERD compared with subjects without GERD. However, our data in Hispanic subjects showed similar prevalence of IBS in patients with NERD, EE and dyspepsia.…”

Section: Discussionmentioning

confidence: 97%

Endoscopic and symptoms analysis in Mexican patients with irritable Bowel syndrome, dyspepsia, and gastroesophageal reflux disease

Camacho

Bernal

Abdo

et al. 2010

An. Acad. Bras. Ciênc.

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The aim of this study was to analyze the data of endoscopy and symptoms in 118 Mexican patients with irritable bowel syndrome (IBS), dyspepsia, non-erosive reflux disease (NERD) and erosive esophagitis (EE). IBS criteria were fulfilling for dyspepsia patients in 47%, for NERD in 48%, and for EE patients in 48% of cases. Esophagitis was present in 42% of patients with IBS and in 45% of patients with dyspepsia. A higher prevalence of hiatus hernia was found in EE vs. NERD. Heartburn and acid eructation were associated with the presence of esophagitis; acid eructation, regurgitation and nocturnal pain with duodenitis; and heartburn and regurgitation with hiatus hernia. Males more frequently reported: mucus in feces, abdominal distension, nausea and gastritis; and women more frequently reported esophagitis and duodenitis. Patients with NERD (OR 2.54, 95% CI 1.08 to 5.99, p=0.04), tenesmus and early satiety, and men had an increase risk for reporting hard or lumpy stools. In conclusion, nearly half of the Mexican patients with NERD, EE and dyspepsia fulfill criteria for IBS. A large number of symptoms were correlated with endoscopy, which can be used to improve the indication of the endoscopy and its implementation in clinical studies.

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“…26,27 Visceral hypersensitivity is also considered a biological marker of IBS, 28 a condition associated with NERD. [6][7][8]29 Recently, Fass et al 30 demonstrated that the perceptual sensitivity to acid is increased under mild acute laboratory stressor like dichotic listening. There was no difference in ratings between patients with erosive oesophagitis and patients with NERD.…”

Section: Discussionmentioning

confidence: 99%

Nondigestive symptoms in non‐erosive reflux disease: nature, prevalence and relation to acid reflux

Hershcovici

Zimmerman

2008

Aliment Pharmacol Ther

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Increased Prevalence of Irritable Bowel Syndrome in Patients With Gastroesophageal Reflux

Abstract: There is a higher prevalence of IBS in subjects with GERD compared with subjects without GERD.

Cited by 58 publications

References 23 publications

Irritable bowel, smoking and oesophageal acid exposure: an insight into the nature of symptoms of gastro‐oesophageal reflux

Irritable bowel, smoking and oesophageal acid exposure: an insight into the nature of symptoms of gastro‐oesophageal reflux

Endoscopic and symptoms analysis in Mexican patients with irritable Bowel syndrome, dyspepsia, and gastroesophageal reflux disease

Nondigestive symptoms in non‐erosive reflux disease: nature, prevalence and relation to acid reflux

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