Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis

Allanore, Yannick; Parc, C.; Monnet, Dominique; Brézin, Antoine P.; Kahan, André

doi:10.1136/ard.2003.013540

Cited by 42 publications

(32 citation statements)

References 15 publications

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“…This autoimmune disease is characterized by excessive collagen production in the skin and other internal organs (Murdaca et al, 2016). Several studies have correlated an increased prevalence of glaucomatous neuropathy in patients with systemic sclerosis, although there was no difference in IOP between patients and controls, which may suggest a link to normal tension glaucoma (Allanore et al, 2004; Gomes Bde et al, 2011; Yamamoto et al, 1999). Systemic sclerosis is characterized by an accumulation of connective tissue components that leads to progressive hardening and scarring of the tissue (Murdaca et al, 2016) In the glaucoma field, much recent discussion has centered on the potential of fibrosis in the TM and optic nerve head leading to decreased compliance and increased stiffness of these tissues (Last et al, 2011; McDonnell et al, 2014; Overby et al, 2014; Yang et al, 2015a).…”

Section: Asb10 and Other Diseasesmentioning

confidence: 92%

Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma

Keller

Wirtz

2017

Experimental Eye Research

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Evidence is accumulating to suggest that mutations in the Ankyrin and SOCS Box-containing protein-10 (ASB10) gene are associated with glaucoma. Since its identification in a large Oregon family with primary open-angle glaucoma (POAG), ASB10 variants have been associated with disease in US, German and Pakistani cohorts. ASB10 is a member of the ASB family of proteins, which have a common structure including a unique N-terminus, a variable number of central ankyrin (ANK) repeat domains and a suppressor of cytokine signaling (SOCS) box at the C-terminus. Mutations in ASB10 are distributed throughout the entire length of the gene including the two alternatively spliced variants of exon 1. A homozygous mutation in a Pakistani individual with POAG, which lies in the center of the SOCS box, is associated with a particularly severe form of the disease. Like other SOCS box-containing proteins, ASB10 functions in ubiquitin-mediated degradation pathways. The ANK repeats bind to proteins destined for degradation. The SOCS box recruits ubiquitin ligase proteins to form a complex to transfer ubiquitin to a substrate bound to the ANK repeats. The ubiquitin-tagged protein then enters either the proteasomal degradation pathway or the autophagic-lysosomal pathway. The choice of pathway appears to be dependent on which lysine residues are used to build polyubiquitin chains. However, these reciprocal pathways work in tandem to degrade proteins because inhibition of one pathway increases degradation via the other pathway. In this publication, we will review the literature that supports identification of ASB10 as a glaucoma-associated gene and the current knowledge of the function of the ASB10 protein. In addition, we present new data that indicates ASB10 expression is up-regulated by the inflammatory cytokines tumor necrosis factor-α and interleukin-1α. Finally, we will describe the emerging role of other SOCS box-containing proteins in protein degradation pathways in ocular cells.

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Section: Asb10 and Other Diseasesmentioning

confidence: 92%

Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma

Keller

Wirtz

2017

Experimental Eye Research

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“…Other literature data showed an association between systemic sclerosis, and keratoconus and pellucid marginal degeneration [13]. Cataract [14]Glaucoma [15], Refractive error [16], Optic disk disease [17], and Retinal changes [18].Up to the best of our knowledge, there is no previous reports about prevalence of ocular manifestation in Iraqi patients with systemic sclerosis. This study aimed to evaluate the prevalence and characteristics of ocular manifestations in Iraqi patients with SSc.…”

Section: Introductionmentioning

confidence: 67%

Ocular Manifestations of Systemic Sclerosis:A Descriptive CrossSectional Study from Iraq

Jawad¹,

Gorial²

2017

IOSR JNHS

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“…This clinical scenario is well described in the literature for both sulcus-placed singlepiece acrylic and 3-piece acrylic-PMMA intraocular lenses. [2][3][4] Indeed, from our own experience, the sequelae here can be significant, requiring aqueous shunt surgery.…”

Section: Sir Stability and Safety Of Ma50 Intraocular Lens Placed Inmentioning

confidence: 97%

“…With a relatively short median long-term follow-up period in this study, more cases of pigment dispersion glaucoma may emerge after a longer follow-up period, as demonstrated in other case series. 3 It may be appropriate to counsel patients of this risk.…”

Section: Sir Stability and Safety Of Ma50 Intraocular Lens Placed Inmentioning

confidence: 99%

Response to Dr Sandhu and Dr Clarke

Kemp

Oetting

2016

Eye

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Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis

Cited by 42 publications

References 15 publications

Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma

Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma

Ocular Manifestations of Systemic Sclerosis:A Descriptive CrossSectional Study from Iraq

Response to Dr Sandhu and Dr Clarke

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