Increased prevalence of osteonecrosis of the femoral head in children and adolescents with sickle‐cell disease

Mahadeo, Kris Michael; Oyeku, Suzette O.; Taragin, Benjamin H.; Rajpathak, Swapnil; Moody, Karen; Santizo, Ruth; Driscoll, Monica

doi:10.1002/ajh.22103

Cited by 56 publications

(56 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This role remains dominated by sickle cell disease, responsible for 70% of femoral head necrosis and 45% of hip diseases in prior studies conducted in Lomé [11]. This predominant etiological role, established in many other countries and regions of Africa, is explained by the high prevalence of sickle cell disease [3][4][5].…”

Section: Discussionmentioning

confidence: 98%

“…Factors favouring necrosis of the femoral head are mainly represented by sickle cell disease, diabetes, alcoholism, corticotherapy, dyslipidaemia, aeroembolism, systemic lupus erythematosus, and upper extremity trauma of the femur [1,2]. In sub-Saharan Africa, hemoglobinopathies are by far the most important etiological factor of this necrosis, which is one of the most serious functional complications [3][4][5][6]. Over the past 20 years, the list of risk factors for bone necrosis has been enriched by HIV infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epiphyseal Necrosis in Patients with HIV Infection and Free from Sickle Cell Disease

Es¹,

Houzou²,

Kakpovi³

et al. 2018

J Autoimmune Disord

View full text Add to dashboard Cite

We report a series of 17 cases of epiphyseal necrosis observed in nine women aged 40 years on average. These nine patients, with HIV1 infection, were free from other risk factors of bone necrosis, especially SS and sickle cell disease. The necrosis affected the two femoral heads in 6 patients, one femoral head in one patient, one humeral head in one patient, and the two femoral heads and one humeral head in the last patient. The necrosis revealed HIV1 infection in 4 patients. It has complicated the course of HIV1 infection in other 5 patients, despite antiretroviral therapy.These observations argue in favor of the etiological role of HIV infection in the occurrence of epiphyseal necrosis. The relatively young age of the patients and the high number of bilateral involvement testify to the severity of the necrosis induced by HIV.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Epiphyseal Necrosis in Patients with HIV Infection and Free from Sickle Cell Disease

Es¹,

Houzou²,

Kakpovi³

et al. 2018

J Autoimmune Disord

View full text Add to dashboard Cite

show abstract

“…However, the effect of hydroxyurea in rising hemoglobin and hematocrit levels leading to increase viscosity and sickling of cells in head of femur circulation. Relying on the previous theory and the increase of AVN incidence in the exposed group they considered hydroxyurea as a confirmed risk factor for developing AVN [13,17]. In further studies it will be useful for practitioners to determine the required and safe hemoglobin levels to be maintained for SCA patients.…”

Section: Discussion:-mentioning

confidence: 99%

“…Osteonecrosis typically affect the hip joint, but it can affect several joints including spine, knees and feet as well [10]. Bilateral disease is common and may occur in 56% of patients [13]. The prevalence of AVN has been investigated in some studies previously.…”

mentioning

confidence: 99%

“…Another study was done at the University Hospital of the West Indies investigated the hematological indices of 50 patients who reported to have AVN, it showed an association between high total hemoglobin and low fetal hemoglobin levels with development of AVN [18]. High hematocrit, hydroxyurea treatment, reduced WBCs, high creatinine levels, male gender, coexistent alpha thalassemia trait and vitamin D deficiency also reported to be positively associated with AVN [8,13]. Vitamin D and calcium levels are critical factors for maintaining an optimum healthy bone structure [7].…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Prevalence of Avascular Necrosis in Adults With Sickle Cell Disease in King Fahad Hospital.

Elmaghraby¹,

Balelah²,

Almahdi³

et al. 2017

IJAR

View full text Add to dashboard Cite

Treatment for avascular necrosis of bone in people with sickle cell disease

Martí‐Carvajal¹,

Solà²,

Agreda-Pérez³

2012

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

We found no evidence that adding hip core decompression to physical therapy achieves clinical improvement in people with sickle cell disease with avascular necrosis of bone compared to physical therapy alone. However, we highlight that our conclusion is based on one trial with high attrition rates. Further randomised controlled trials are necessary to evaluate the role of hip-core depression for this clinical condition. Endpoints should focus on participants' subjective experience (e.g. quality of life and pain) as well as more objective 'time-to-event' measures (e.g. mortality, survival, hip longevity). The availability of participants to allow adequate trial power will be a key consideration for endpoint choice.

show abstract

Increased prevalence of osteonecrosis of the femoral head in children and adolescents with sickle‐cell disease

Cited by 56 publications

References 18 publications

Epiphyseal Necrosis in Patients with HIV Infection and Free from Sickle Cell Disease

Epiphyseal Necrosis in Patients with HIV Infection and Free from Sickle Cell Disease

The Prevalence of Avascular Necrosis in Adults With Sickle Cell Disease in King Fahad Hospital.

Treatment for avascular necrosis of bone in people with sickle cell disease

Contact Info

Product

Resources

About