Increased prevalence of precancerous changes in relatives of gastric cancer patients: Critical role of H. pylori

El‐Omar, Emad; Oien, Karin A.; Murray, Lilian S.; El-Nujumi, A.; Wirz, Angela A.; Gillen, Derek; Williams, Craig; Fullarton, Grant; McColl, Kenneth E.L.

doi:10.1016/s0016-5085(00)70410-0

Cited by 281 publications

(224 citation statements)

References 36 publications

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“…19 Moreover, relatives of cancer patients with H. pylori infection have an increased prevalence of hypochlorhydria and atrophic gastritis, 20 both of which are precancerous abnormalities. 21 In our study, we also found that the frequency of atrophic gastritis with or without intestinal metaplasia was higher in H. pylori-infected relatives of cancer patients than in H. pylori-infected controls (OR 2.4; 95% CI 1.5-3.8).…”

Section: Discussionmentioning

confidence: 99%

Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients

Chang

Han

Lee

et al. 2002

Intl Journal of Cancer

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A positive family history is an increased risk factor for gastric cancer within family members, and one of the possible causes of this is the intrafamilial clustering of Helicobacter pylori infection. Our study examined the prevalence of H. pylori infection, serum antibodies to CagA and VacA and atrophic gastritis and/or intestinal metaplasia in the offspring or siblings of gastric cancer patients. A total of 726 subjects included 300 relatives of 300 separate gastric cancer patients and 426 controls. All subjects underwent upper gastrointestinal endoscopic examination with a rapid urease test. Blood samples were obtained to test for the presence of serum antibodies to the CagA and VacA proteins of H. pylori. The prevalence of H. pylori infection was higher in relatives of cancer patients (75.3%) than in controls (60.1%), and the adjusted odds ratio was 2.1 (95% CI 1.5-2.9). When either siblings or 2 or more family members were gastric cancer patients, the prevalence of H. pylori infection was much higher compared to the prevalence in controls. Gastric cancer is the second most common cause of cancerrelated death in the world. 1 In Korea, gastric cancer is the most frequently diagnosed malignancy, although the associated mortality rate has been decreasing slowly for the past 10 years. 2 About 60% of Korean adults are infected with Helicobacter pylori. 3,4 Such infection is a causative factor in gastric carcinogenesis, and H. pylori infection is associated with a 2-fold increased risk of developing gastric adenocarcinoma. 5,6 A positive family history is also associated with an increased risk of gastric cancer. 7-10 The possible causes of familial aggregation of gastric cancer are common genetic backgrounds and common environmental risk factors including H. pylori infection, excessive intake of salt and N-nitroso compounds and a deficiency of dietary antioxidants among patients with gastric cancer and their family members. Among these risk factors, intrafamilial clustering of H. pylori infection is regarded as a leading cause of gastric carcinogenesis. This association is significantly greater for H. pylori strains that possess the cytotoxin-associated gene cagA, [11][12][13] a key gene of the so-called "pathogenicity island". 14 The first aim of our study was to examine the prevalence of H. pylori infection in offspring and siblings of patients with gastric cancer to evaluate its role in intrafamilial aggregation of gastric cancer. The second aim was to investigate the relationship between CagA or vacuolating cytotoxin (VacA) seropositivity as virulence markers of H. pylori strains and H. pylori infection in relatives of cancer patients. Finally, we examined the frequency of gastric precancerous lesion, atrophic gastritis and/or intestinal metaplasia in the H. pyloriinfected relatives of cancer patients. MATERIAL AND METHODS Recruitment of relatives of cancer patients and controlsFrom November 2000 to March 2002, we recruited subjects who wished to receive routine upper gastrointestinal endoscopy and evaluation ...

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Section: Discussionmentioning

confidence: 99%

Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients

Chang

Han

Lee

et al. 2002

Intl Journal of Cancer

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“…Furthermore, epidemiological data on gastric cancer is incomplete in many regions, and non-invasive methods for diagnosing the infection are not widely available. (173) and case-control studies conducted in Asia (188) , Europe (47,61) and Latin America (149) , including Brazil (147) , show that first-degree relatives of gastric cancer carriers have a 2 to 3 times higher risk of developing neoplasia, so search and eventual eradication of bacteria in this population is fully justified. Metachronous tumors in the gastric remnant have been described in up to 10% of patients undergoing gastric, endoscopic or surgical resection for early gastric cancer (182,187,194) .…”

Section: Statement 19mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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“…40 H. pylori-mediated carcinogenesis may be accelerated in the context of host and environmental factors, which include family history of gastric adenocarcinoma, atrophic gastritis, specific host genetic polymorphisms, intake of nitrosoamine compounds (found in cured meats and fish) and high salt diets. [41][42][43] For example, patients with H. pylori infection and a family history of gastric adenocarcinoma have a three-fold increase in the incidence of gastric adenocarcinoma. 44 …”

Section: H Pylori Mediated Cancer Progressionmentioning

confidence: 99%

Helicobacter pylori: Evidence-Based Review with a Focus on Immigrant Populations

Siao

Somsouk

2013

J GEN INTERN MED

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Increased prevalence of precancerous changes in relatives of gastric cancer patients: Critical role of H. pylori

Abstract: Relatives of patients with gastric cancer have an increased prevalence of precancerous gastric abnormalities, but this increase is confined to those with H. pylori infection. Consequently, prophylactic eradication of the infection should be offered to such subjects.

Cited by 281 publications

References 36 publications

Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients

Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Helicobacter pylori: Evidence-Based Review with a Focus on Immigrant Populations

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