Increased Prevalence of Thyroid Nodules Across Nearly 10 Years in Shanghai, China

Qu, Mengying; Tang, Wei; Cui, Xueying; Jin, Young-Woo; Wang, Zhengyuan; Guo, Changyi; Jia, Xiaodong; Shi, Yong-Quan; Zang, Jiajie

doi:10.1007/s11596-022-2666-5

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…A previous study reported that the global prevalence of thyroid nodules has reached 4-7%, of which 8-16% turn into thyroid cancer [3]. In recent years, the prevalence of thyroid nodules in China has shown a concerning increase, with various studies reporting prevalence rates ranging from 10% to 50% [4][5][6][7]. For example, a study involving 6,985,956 participants (mean age: 42.1 ± 13.1 years) from 30 provinces and regions in China indicated an overall prevalence of thyroid nodules of 36.9% [4].…”

Section: Introductionmentioning

confidence: 99%

Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study

Zhu,

Meng,

Cheng

et al. 2024

International Journal of Endocrinology

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Objective. To explore associations of combined exposure to metabolic/inflammatory indicators with thyroid nodules. Methods. We reviewed personal data for health screenings from 2020 to 2021. A propensity score matching method was used to match 931 adults recently diagnosed with thyroid nodules in a 1 : 4 ratio based on age and gender. Conditional logistic regression and Bayesian kernel machine regression (BKMR) were used to explore the associations of single metabolic/inflammatory indicators and the mixture with thyroid nodules, respectively. Results. In the adjusted models, five indicators (ORQ4 vs. Q1: 1.30, 95% CI: 1.07–1.58 for fasting blood glucose; ORQ4 vs. Q1: 1.30, 95% CI: 1.08–1.57 for systolic blood pressure; ORQ4 vs. Q1: 1.26, 95% CI: 1.04–1.53 for diastolic blood pressure; ORQ4 vs. Q1: 1.23, 95% CI: 1.02–1.48 for white blood cell; ORQ4 vs. Q1: 1.28, 95% CI: 1.07–1.55 for neutrophil) were positively associated with the risk of thyroid nodules, while high-density lipoproteins (ORQ3 vs. Q1: 0.75, 95% CI: 0.61–0.91) were negatively associated with the risk of thyroid nodules. Univariate exposure-response functions from BKMR models showed similar results. Moreover, the metabolic and inflammatory mixture exhibited a significant positive association with thyroid nodules in a dose-response pattern, with systolic blood pressure being the greatest contributor within the mixture (conditional posterior inclusion probability of 0.82). No interaction effects were found among the five indicators. These associations were more prominent in males, participants with higher age (≥40 years old), and individuals with abnormal body mass index status. Conclusions. Levels of the metabolic and inflammatory mixture have a linear dose-response relationship with the risk of developing thyroid nodules, with systolic blood pressure levels being the most important contributor.

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Section: Introductionmentioning

confidence: 99%

Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study

Zhu,

Meng,

Cheng

et al. 2024

International Journal of Endocrinology

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“…Global statistics from the World Health Organization (WHO) indicate that TC contributed to 586,000 cases worldwide in 2020, ranking ninth in terms of incidence (6). In China, TNs have shown an escalating trend in incidence over the past two decades, with TC emerging as one of the most rapidly increasing malignancies (7). Notably, TN and TC has also been acknowledged in China's Medium-and Long-Term Plan for Chronic Disease Prevention and Treatment (2017-2025).…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude, and practice towards thyroid nodules and cancer among patients: a cross-sectional study

Li,

Deng,

Xiong

et al. 2023

Front. Public Health

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AimThis study aimed to explore the knowledge, attitude, and practice (KAP) towards thyroid nodules (TN) and thyroid cancer (TC) among patients.Subject and methodsThis cross-sectional study enrolled patients with TN or TC at the Second Affiliated Hospital of the University of South China between September 2022 and February 2023. A self-administered questionnaire was developed to collect demographic information of the participants, and their knowledge, attitude and practice (KAP) towards TN and TC.ResultsA total of 510 valid questionnaires were collected. Among the participants, 102 (20.00%) were male, and 197 (38.63%) had the diagnosis of TC. The knowledge, attitude and practice scores were 5.76 ± 3.09 (possible range: 0–12), 31.07 ± 2.73 (possible range: 9–45), and 18.97 ± 2.92 (possible range: 5–25), respectively. Multivariate logistic regression showed that age of above 50 years old (OR = 0.27, 95%CI: 0.12–0.64, p = 0.003), junior college or bachelor’s degree and above (OR = 4.97, 95%CI: 1.74–14.20, p = 0.003), monthly income of 5,000–10,000 CNY (OR = 2.02, 95%CI: 1.09–3.74, p = 0.025) and > 10,000 CNY (OR = 5.67, 95%CI: 2.49–12.94, p < 0.001) were independently associated with knowledge. The good knowledge (OR = 3.87, 95%CI: 1.89–7.95, p < 0.001), high school or technical secondary school (OR = 0.52, 95%CI: 0.30–0.88, p = 0.016), and monthly income of 5,000–10,000 CNY (OR = 2.02, 95%CI: 1.13–3.63, p = 0.018) were independently associated with practice.ConclusionPatients demonstrated poor knowledge, moderate attitude, and proactive practice towards TN and TC.

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The influence of nutrition in nodular thyroid pathology: a systematic review

Neto,

Leitão,

Estrela

et al. 2024

Critical Reviews in Food Science and Nutrition

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Increased Prevalence of Thyroid Nodules Across Nearly 10 Years in Shanghai, China

Cited by 4 publications

References 17 publications

Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study

Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study

Knowledge, attitude, and practice towards thyroid nodules and cancer among patients: a cross-sectional study

The influence of nutrition in nodular thyroid pathology: a systematic review

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