Increased prevalence of vascular dementia in Japan

Ikeda, Manabu; Hokoishi, Kazuhiko; Maki, Naruhiko; Nebu, Akihiko; Tachibana, Nozomi; Komori, Kenjiro; Shigenobu, Kazue; Fukuhara, Ryuji; Tanabe, Hirotaka

doi:10.1212/wnl.57.5.839

Cited by 152 publications

(115 citation statements)

References 39 publications

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“…Also there was a predominance of males in studies of early onset dementia 23,24 . AD is the most frequent etiology in studies with early onset dementia 2,4,[23][24][25][26][27] , although in one report VaD is the most prevalent (Southampton area) 26 as well as in the Japanese study 28 . In our clinic VaD was the most important cause of dementia, with a frequency of 36.9% and increasing prevalence after 50 years.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of presenile dementia in a tertiary outpatient clinic

Fujihara

Brucki

Rocha

et al. 2004

Arq. Neuro-Psiquiatr.

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-There are very few reports about prevalence of presenile dementia in Brazil. We reviewed files of patients evaluated with early onset of cognitive impairment in our institution. Among 141 patients (61% males) there was no difference between gender by age at onset or at first evaluation. We have observed an increasing number of patients after 50 years. The most frequent causes were: vascular dementia (36.9%), Alzheimer's disease (20.3%) and traumatic brain injury (9.2%). There was difference among dementia type by age of onset and first evaluation, educational level and length of dementia. These results may be compared with those from other neurologic services in order to replicate or confirm these results.KEY WORDS: presenile dementia, vascular dementia, Alzheimer's disease, epidemiology. Prevalência de demência pré-senil num ambulatório terciárioRESUMO -Em nosso meio há raros estudos que verifiquem quais as causas mais prevalentes de demência pré-senil. Avaliamos retrospectivamente os prontuários de pacientes com início precoce de alterações cognitivas, ambulatório de Neurologia da Cognição do Hospital Santa Marcelina. Entre os 141 sujeitos (61% de homens) não houve diferença quanto às idades de início e à primeira consulta e escolaridade entre os sexos. Observamos aumento no número de demência após os 50 anos. A causa mais freqüente foi vascular (36,9%), seguida por doença de Alzheimer (20,3%) e secundária a trauma cranio encefálico (9,2%). Houve diferença entre os tipos de demência quanto à idade na primeira consulta e idade de início, escolaridade e duração do quadro. Ao contrário de outros estudos o diagnóstico mais freqüente foi demência vascular. Novos estudos em nosso meio deverão ser realizados para avaliar este achado nas demências de início precoce.PALAVRAS-CHAVE: demência pré-senil, demência vascular, doença de Alzheimer, epidemiologia.Dementia is a disorder of greater prevalence in older subjects, but many cases can begin in an early age, affecting people in a productive phase of their lives. A syndrome characterized by many cognitive deficits of sufficient severity to interfere with daily life activities and in quality of life. It is a public health problem due its expensive treatment and dependence of patients for governmental sources for sustainability. There are a few studies in epidemiology of presenile dementia comparing to an older onset or familiar Alzheimer's disease (AD) [1][2][3] . The prevalence of presenile dementia is lower that ones with onset in the elderly. Harvey et al. 4 reported that the prevalence increases exponentially between 45 to 60 years of age; this finding was replicated by another three epidemiological studies [5][6][7] . The most frequent diagnosis in early onset dementia is:Alzheimer's disease, followed by vascular dementia (VaD) and frontotemporal dementia (FTD) 8 . There are no studies analyzing the prevalence of presenile dementia in our country in a search in MEDLINE. Other authors have reported diagnostic prevalence in senile dementia or overall rates o...

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Section: Discussionmentioning

confidence: 99%

Prevalence of presenile dementia in a tertiary outpatient clinic

Fujihara

Brucki

Rocha

et al. 2004

Arq. Neuro-Psiquiatr.

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“…In Europe, the prevalence rate is approximately 16/1000 in people over 65 years old, representing approximately 20% of all dementia cases (Ikeda et al, 2001;Lobo, Launer et al, 2000). Moreover, in some Asian countries, VaD appears to be more prevalent than AD (Ikeda et al, 2001;Ueda, Kawano, Hasuo, & Fujishima, 1992).…”

Section: Introductionmentioning

confidence: 99%

Montreal Cognitive Assessment (MoCA): Validation Study for Vascular Dementia

Freitas

Simões

Alves

et al. 2012

J Int Neuropsychol Soc

124

111

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“…3 VaD is induced by cerebrovascular disease; it is considered the most common secondary cause of dementia. 4,5 Less common but important causes of dementia are DLB and FTLD. 5,6 Small hypointense foci in the brain on T2*-weighted gradient recalled-echo and SWI are thought to be microbleeds.…”

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confidence: 99%